Creative Biolabs provides flexible and reliable design, manufacturing and development services for polymer microfluidic systems. We also offer a wide range of ready-to-use microfluidic chips with different functions to meet your demands.
Polydimethylsiloxane (PDMS) has become the material of choice for manufacturing microfluidic devices due to the development of soft lithography techniques. PDMS chip has the following advantages:
PDMS is easy to manufacture and can be created quickly by a skilled operator with a small amount of equipment.
It offers ultra-fine processing resolution and high structural fidelity.
It is almost non-fluorescent, well-suited for biological detection requiring fluorescence.
It has inherent gas permeability, allowing for oxygen and carbon dioxide exchange in cell culture models.
PDMS is ideal for high-precision, low-cost test prototype chip manufacturing.
However, PDMS microfluidic systems also have significant limitations. PDMS has inherent hydrophobic surface that increases the chance of non-specific absorption of drug components and biological molecules. Although surface treatment can temporarily alleviate this effect, such treatments often cannot last long. PDMS is highly susceptible to damage from organic solvents, restricting its application to water-based systems. The flexibility of PDMS limits the depth-to-width ratio of channels and excludes it from large-scale mass production.
Thermoplastic Chips
Thermoplastic materials, such as PMMA, PC, PET, COC, and COP, are also widely used in microfluidic chip manufacturing. These materials can resist harmful effects from solvents and chemicals, have good transparency, and are suitable for various biological experiments. However, the forming technology restricts the application of these materials, and common processing methods can only achieve a scale of 100μm. Additionally, expensive mold opening costs limit the application of these chips to large-scale production. Although plastic chips can be low-cost and rapidly produced by machining, they often have poor surface smoothness. Thermoplastic materials have excellent air tightness, allowing for experiments related to hypoxia, but also limit long-term cell culture within the chip.
Our website provides more detailed information about both PDMS chips and thermoplastic chips. We have created an extensive inventory of microfluidic chips to meet your daily experimental needs. You can also directly contact our experts and discuss your needs, we will comprehensively evaluate your ideas and provide you with feasible and cost-effective solutions.
Q&As
Q: What types of Polymer Chip Products are available for drug development research?
A: Our Polymer Chip Products encompass a range of devices, including microfluidic chips, pumps, valves, and mixers. These devices are designed with precision and reliability to meet the specific needs of drug development researchers, offering versatility and scalability in experimental workflows.
Q: How do Polymer Chip Products enhance drug development research processes?
A: Polymer Chip Products streamline drug development research by enabling high-throughput screening, controlled drug delivery, and advanced analysis techniques. These devices offer precise fluid control, reduced sample consumption, and compatibility with various experimental protocols, ultimately accelerating scientific discovery.
Q: Can you provide examples of successful applications of Polymer Chip Products in drug development?
A: Polymer Chip Products have been successfully applied in drug development research for tasks such as cell culture, drug screening, pharmacokinetic studies, and biomarker analysis. These applications demonstrate the versatility and effectiveness of polymer-based microfluidic devices in advancing scientific research.
Q: How does your company ensure the quality and reliability of Polymer Chip Products?
A: We uphold strict quality control standards throughout the design, fabrication, and testing of our Polymer Chip Products. Our team utilizes advanced manufacturing techniques and conducts thorough quality assurance checks to ensure that each device meets the highest standards of performance and reliability.
Q: What level of support can researchers expect when using Polymer Chip Products?
A: Researchers can expect comprehensive support from our team of microfluidics experts throughout their use of Polymer Chip Products. We provide assistance with device selection, experimental design, troubleshooting, and optimization, ensuring a seamless and successful experience for our clients in drug development research.
Customer Reviews
Remarkable Quality and Consistency
"I'm amazed by the polymer chip product from Creative Biolabs. Its user-friendly design and precise fluid handling capabilities revolutionized my lab's drug development research. We achieved unprecedented efficiency and accuracy in our experiments, thanks to this innovative microfluidic device. Highly recommended for researchers seeking reliable solutions!"
Excellent Support.
"The polymer chip product provided by Creative Biolabs exceeded my expectations. Its high-quality fabrication and seamless integration into our experimental workflows significantly boosted our productivity in drug screening and pharmacokinetic studies. This versatile microfluidic device has become an indispensable tool in our research arsenal."
Excellent Support.
"I can't speak highly enough of the polymer chip product from Creative Biolabs. Its robust construction and exceptional performance have transformed our drug development research. With precise fluid control and minimal sample consumption, we've achieved remarkable results and accelerated our progress towards novel therapeutics. Truly a game-changer in microfluidics!"
Resources
Videos
Creative Biolabs has established a comprehensive microfluidics technique platform.
Product Overview: The sperm screening chip is an advanced technology tool designed for fertility treatment. Its core advantages include efficient sorting of ideal sperm, no need for cumbersome sample preparation, and standardized and streamlined operation procedures.
Product Overview: The plant root chip simulates the complex growth environment of plant roots in the soil, providing an experimental platform for real-time monitoring of root growth, morphological changes and responses to external stimuli.
Product Overview: Microfluidic mother machine chips utilize microstructures such as tiny channels, micro reaction chambers, and micro valves to enable highly precise manipulation and observation of mother cells at the microscopic scale.
Product Overview: Cell capture chips can achieve efficient capture, positioning and analysis of cells through tiny fluid channels and functional surface structures.
Product Overview: A series of micron-scale obstacles are designed on the microchannel surface of the DLD sorting chip, which can cause the particles to deviate in the flow of tiny liquids, thereby achieving particle sorting.
Product Overview: Our flow-focusing droplet generation chip employs the theory of cross-flow focusing. It utilizes a continuous phase to squeeze the dispersed phase, which is introduced from both sides, toward the center. This results in the destabilization of the interface and the formation of stable droplets. This chip is suitable for uniform, continuous, and rapid droplet generation. It can also be used for single-cell encapsulation when cell suspensions are used as the dispersed phase. It is important to note that while we provide expected droplet sizes, the actual size achieved depends on the specific configuration used in your experiments.
Product Overview: BE-Gradient Barrier-Free consists of a central cell culture chamber and two adjacent channels that come into direct contact with it. Varying the concentration of elements in the adjacent channels generates chemical gradients in the cell culture chamber. BE-Gradient Barrier-Free is an excellent tool for studying 3D ischemia, cell invasion, migration, and endothelialization.
Product Overview: With the utilization of laminar flow theory and a branching channel network, our Christmas tree network gradient chip can help you establish stable and long-lasting concentration gradients. Our standard chip design can generate nine different concentration gradients in the 2D plane. However, it is also feasible to create more (or fewer) concentration gradients, implement different outlet designs, or even construct 3D concentration gradients based on your specific requirements.
Product Overview: This is the simplest yet most complex type of chip. The straight channel chip is an excellent tool for studying cell adhesion, cell-cell/particle interactions, and shear forces. With simple modifications, it can also be utilized as a toxicology screening or biological detection chip. For this type of chip, we offer a variety of customizable options including length, width, depth, number of channels, volume, material, and surface modifications. Whatever your requirements may be, we are committed to fulfilling them and providing you with a tailored solution.
Product Overview: We offer cross-shaped, T-shaped, and Y-shaped channel chips for applications such as studying shear forces on cells or the more common capillary electrophoresis. For these types of chips, we provide various shapes, channel size options, and additional customization services to meet any specific requirements you may have.
Product Overview: Experiencing our snake-shaped continuous flow PCR chip for fast, efficient, highly specific, and cost-effective PCR detection. In fact, all you need is a simple heating module to support the functionality of this chip. We offer customized chip services to cater to different sample types, detection cycles, and detection principles. Depending on your requirements, we can tailor the chip design accordingly.
Product Overview: Our Janus microsphere generation chip utilizes a classic and effective flow-focusing structure to produce continuous and stable Janus microspheres. This chip is designed for various applications, including single-cell sequencing library preparation, by integrating cell suspensions and appropriate microbeads. We offer nozzle sizes of 30, 50, and 100 μm to meet different requirements for droplet sizes. Additionally, we provide both hydrophilic and hydrophobic versions for different chip sizes, allowing compatibility with various experimental conditions.
Product Overview: Three channels are deployed on each chip, allowing researchers to study cell shear effects and adhesion behavior under different channel sizes or flow rate environments. This simplified channel design can be easily modified for detection purposes. Additionally, we also provide customization services for this chip in terms of size, channel quantity, and structure. This ensures that you have the flexibility to tailor the chip to your specific experimental needs and research objectives.
Product Overview: The branching channel chip is a simplified model of symmetric/asymmetric branching, providing a visual and quantifiable research platform for studying cell-particle/cell interactions. It is an excellent tool for investigating cell adhesion-related research. In addition to the standard angles, we also offer customized designs in terms of size and configuration to cater to specific research requirements and experimental settings.
Product Overview: This chip utilizes a pseudo-random microvascular network to replicate cell-particle or cell-cell interactions in an in vitro environment. It enables the visualization of shear adhesion and branching adhesion in a single experiment. This allows researchers to study and understand the dynamics of these interactions under controlled conditions. We provide different structural versions of this chip for parallel validation purposes.
Product Overview: BE-Doubleflow is an advanced device consisting of two perfusion channels connected by a porous membrane, and is your best choice for studying circulating particles, cell interactions and simple organ on chip system construction.
Product Overview: BE-Transflow is our versatile cell culture platform, which can be used to construct cell interface or Air-Liquid interface (ALI) to study more complex culture systems.
Product Overview: BE-Doubleflow Standard is an advanced device consisting of two perfusion channels connected by a porous membrane, and is your best choice for studying circulating particles, cell interactions and simple organ on chip system construction.
Product Overview: BE-Transflow Standard is our versatile cell culture platform, which can be used to construct cell interface or Air-Liquid interface (ALI) to study more complex culture systems.
PDMS is easy to manufacture and can be created quickly by a skilled operator with a small amount of equipment.
It offers ultra-fine processing resolution and high structural fidelity.
It is almost non-fluorescent, well-suited for biological detection requiring fluorescence.
It has inherent gas permeability, allowing for oxygen and carbon dioxide exchange in cell culture models.
PDMS is ideal for high-precision, low-cost test prototype chip manufacturing.
