Creative Biolabs provides flexible and reliable design, manufacturing and development services for polymer microfluidic systems. We also offer a wide range of ready-to-use microfluidic chips with different functions to meet your demands.
Polydimethylsiloxane (PDMS) has become the material of choice for manufacturing microfluidic devices due to the development of soft lithography techniques. PDMS chip has the following advantages:
PDMS is easy to manufacture and can be created quickly by a skilled operator with a small amount of equipment.
It offers ultra-fine processing resolution and high structural fidelity.
It is almost non-fluorescent, well-suited for biological detection requiring fluorescence.
It has inherent gas permeability, allowing for oxygen and carbon dioxide exchange in cell culture models.
PDMS is ideal for high-precision, low-cost test prototype chip manufacturing.
However, PDMS microfluidic systems also have significant limitations. PDMS has inherent hydrophobic surface that increases the chance of non-specific absorption of drug components and biological molecules. Although surface treatment can temporarily alleviate this effect, such treatments often cannot last long. PDMS is highly susceptible to damage from organic solvents, restricting its application to water-based systems. The flexibility of PDMS limits the depth-to-width ratio of channels and excludes it from large-scale mass production.
Thermoplastic Chips
Thermoplastic materials, such as PMMA, PC, PET, COC, and COP, are also widely used in microfluidic chip manufacturing. These materials can resist harmful effects from solvents and chemicals, have good transparency, and are suitable for various biological experiments. However, the forming technology restricts the application of these materials, and common processing methods can only achieve a scale of 100μm. Additionally, expensive mold opening costs limit the application of these chips to large-scale production. Although plastic chips can be low-cost and rapidly produced by machining, they often have poor surface smoothness. Thermoplastic materials have excellent air tightness, allowing for experiments related to hypoxia, but also limit long-term cell culture within the chip.
Our website provides more detailed information about both PDMS chips and thermoplastic chips. We have created an extensive inventory of microfluidic chips to meet your daily experimental needs. You can also directly contact our experts and discuss your needs, we will comprehensively evaluate your ideas and provide you with feasible and cost-effective solutions.
Product Overview: This product is a Centrifuge Microfluidic Chip with integrated Luer connections ensure leak-free junctions to the tubing. It can be used for processing samples and reagents in nucleic acid analysis, blood analysis, immunoassays and point-of-care diagnostics.
Product Overview: The Serpentine Droplet Generator Microfluidic Chip is made up of two parts: the upper part made of Polycarbonate with serpentine channel and the lower part made up of PDMS or glass coverslip in which microfluidic circuits are patterned.
Product Overview: Nanoparticle Generation Microfluidic Chip is a easy-to-use device for the generation of nanoparticles with well-controlled size and shape.
To cater to diverse experimental requirements, we offer different types of mixing chips: herringbone chip, split-converge chip and the zigzag mixing chip.
Standard chips are suitable for producing nanoparticles at 40-200nm (depending on your experimental configuration). We also can customize nanoparticle microfluidic chips according to the customer's specific project.
Product Overview: This Neuron Cell Culture chip contains a microchannel array can separate neurons and provide a physical and chemical way to manipulate neuronal subcellular areas, including the body, dendrites, axons, and synapses.
Product Overview: Integrated 3D Cell Culture Chip are consisted of two plastic plates, and typically is used for patch integration for which micro-chambers and micro-channels are predefined in both plastic plates. Integrated 3D Cell Culture Chip can be used to construct any organ-on-a-chip type that has a membrane structure. When used, a tissue patch is placed between the two plates, culture media containing different factors can flow in the upper and lower chambers separated by the patch.
Product Overview: Multifunction 3D Cell Co-Culture Chip is a easy-to-use microfluidic device with three interconnected channels. This chip can recreate a biological microenvironment for a wide range of applications and assays. We also offer an additional version with denser separators that effectively separate cells. This particular version is suitable for co-culturing cells, constructing physiological concentration gradients, and conducting research related to cell migration.
Product Overview: The Particle & Cell Spiral Sorting Microfluidic Chip is a particle/cell sorting system with four different sizes made by PMMA. It can be used for accurately separating particles according to their size based on the Dean forces.
Product Overview: Idealized Co-Culture Network Chips (IMN2 Radial) is a microfluidic chip which can be applied for constructing SynBBB 3D Blood Brain Barrier Model, SynRAM 3D Inflammation Model, SynTumor 3D Cancer Model and SynTox 3D Toxicology Model. We provide an additional version of this chip that incorporates micro pillar separation or different size configurations.
Product Overview: Idealized Co-Culture Network Chips (IMN2 TEER) is a microfluidic chip which can be applied for constructing SynBBB 3D Blood Brain Barrier Model. Compared with conventional BBB organ chips, IMN2 TEER is equipped with built-in electrodes so that you can directly conduct electrical analysis, which will allow you to quantify changes and formation of tight junctions in endothelial cells.
Product Overview: Idealized Co-Culture Network Chips (IMN2 Linear) is a microfluidic chip which can be applied for constructing SynBBB 3D Blood Brain Barrier Model, SynTumor 3D Cancer Model, SynTox 3D Toxicology Model. Compared to radial chips, linear chip structures are more suitable for constructing stable, visible, and quantifiable air-liquid interfaces. We also provide an additional version of this chip that incorporates micro pillar separation or a version with wider channel widths(100/250/500 μm).
Product Overview: SMN2 microvascular network Co-Culture Chips is a microfluidic chip which can be applied for constructing SynRAM 3D Inflammation Model, SynTumor 3D Cancer Model, SynALI Lung Model. This chip utilizes a simplified in vitro-derived microvascular network with a pseudo-random pattern. The complex structure enables the realistic representation of cellular composition and vascular morphology, thereby reproducing the intricate shear and flow conditions present in vivo. We also provide chips with different pseudo-random structures or multi-chambered chips for additional validation purposes. The co-culture network constructs are available with several options for channel size, tissue region scaffolding, barrier design, and can also construct custom designs if needed.
Product Overview: BE-Flow Standard is an easy to use divece for long-term 2D/3D cell culture and mechanical shear stress studies by means of microfluidics.
Product Overview: BE-Gradient Standard enables electrochemical gradients for 3D cell culture via three small microchannels connected between a central chamber and lateral channels.
Product Overview: BE-Transflow Standard is our versatile cell culture platform, which can be used to construct cell interface or Air-Liquid interface (ALI) to study more complex culture systems.
Product Overview: BE-Doubleflow Standard is an advanced device consisting of two perfusion channels connected by a porous membrane, and is your best choice for studying circulating particles, cell interactions and simple organ on chip system construction.
Product Overview: BE-Transflow is our versatile cell culture platform, which can be used to construct cell interface or Air-Liquid interface (ALI) to study more complex culture systems.
Product Overview: BE-Doubleflow is an advanced device consisting of two perfusion channels connected by a porous membrane, and is your best choice for studying circulating particles, cell interactions and simple organ on chip system construction.
Product Overview: This chip utilizes a pseudo-random microvascular network to replicate cell-particle or cell-cell interactions in an in vitro environment. It enables the visualization of shear adhesion and branching adhesion in a single experiment. This allows researchers to study and understand the dynamics of these interactions under controlled conditions. We provide different structural versions of this chip for parallel validation purposes.
Product Overview: The branching channel chip is a simplified model of symmetric/asymmetric branching, providing a visual and quantifiable research platform for studying cell-particle/cell interactions. It is an excellent tool for investigating cell adhesion-related research. In addition to the standard angles, we also offer customized designs in terms of size and configuration to cater to specific research requirements and experimental settings.
PDMS is easy to manufacture and can be created quickly by a skilled operator with a small amount of equipment.
It offers ultra-fine processing resolution and high structural fidelity.
It is almost non-fluorescent, well-suited for biological detection requiring fluorescence.
It has inherent gas permeability, allowing for oxygen and carbon dioxide exchange in cell culture models.
PDMS is ideal for high-precision, low-cost test prototype chip manufacturing.
