Custom Organ-on-Chip and Cell Culture Model Development
The cell culture and organ-on-a-chip model development services provided by Creative Biolabs are capable of simulating complex human microenvironments in vitro. These services play a crucial role in new drug testing, disease treatment, and other related fields.
Get a Quote Now
Cell culture and organ-on-a-chip model development services integrate cell culture with microfluidic chips into an integrated research system. Its goal is to simulate and reconstruct organ-like structures in vitro, enabling real-time and non-invasive monitoring of the physiological activities of these organ models, thereby fulfilling scientific research objectives.
Fig. 1 Multi-throughput multi-organ-on-a-plate systems.1,4
Creative Biolabs' services primarily include in vitro establishment of cell lines and their seeding onto chips to simulate in vivo metabolic conditions. They also cover additional service types such as 3D cell co-culture, organoid models, and multi-organ chips, with a core commitment to providing a pioneering in vitro platform for biomedical research.
Service Content
Cell Culture Services
Custom Cell Line Establishment
We can isolate and culture primary cells from various tissues, such as liver, lung, and heart. Additionally, we also provide immortalized cell lines that retain key metabolic functions.
3D Cell Culture and Organoid Generation
Moving beyond traditional 2D cultures, our 3D cell culture models, including organoids, better recapitulate the in vivo architecture and function of organs.
Organ-On-A-Chip Model Development
Design of Chip
Our customized organ-on-a-chip platforms are co-developed and manufactured by a collaborative team of technically supported engineers and biologists with extensive research experience.
Using advanced microfabrication technology, we construct microfluidic channels and chambers on the chips that enable precise regulation of the flow of various nutrients, oxygen, and other substances.
Cell Seeding and Integration
Cells relevant to target organs are seeded onto organ-on-a-chip platforms. We then simulate the physiological state of the organs in vitro and optimize co-culture conditions to ensure that the cells function normally on the organ chips.
Multi-Organ Chip System
To enable more comprehensive research, we have developed multi-organ chip systems, which connect different organ-on-a-chip units to investigate inter-organ interactions.
Partner With Us
Service Advantages
Physiological Relevance
The organ-on-a-chip technology we employ excels at simulating the in vivo environment.
Reduced Animal Use
Our services can significantly reduce the need for animal experiments.
High-Throughput
We offer high-throughput screening capabilities on our organ-on-a-chip platforms, allowing for the rapid testing of multiple compounds or conditions.
Customizability
We identify the optimal biological organ-on-chip setup for you.
Comprehensive and fast
Our motivated, well trained scientific team individually plans the scope of your study together with you, sets milestones and criteria for go and no-go decisions.
Contact Us Now
Service Process
|
Consultation
|
We start with an in-depth consultation to understand the client's research goals, hypotheses, and experimental requirements. Our team of experts provides advice on the most suitable cell culture and organ-on-a-chip models for their project.
|
|
Design and Planning
|
Based on the consultation, we design a detailed experimental plan, including the selection of cell types, chip design, and experimental parameters. We also provide a timeline and cost estimate for the project.
|
|
Model Development and Validation
|
Our scientists have since continued to develop cell culture models and organ-on-a-chip platforms. At each stage, we conduct rigorous validation, including chip functionality testing, cellular gene expression analysis, and histological examination.
|
|
Data Collection and Analysis
|
Once the models are validated, we conduct the experiments according to the client's protocol. We collect high-quality data, which is then analyzed by our team of data scientists. We provide detailed reports with statistical analysis and interpretation of the results.
|
|
Client Training and Support
|
Upon completion of the project, we offer training to the client on how to use and maintain the models if required. We also provide ongoing technical support to address any questions or issues that may arise.
|
Start Your Project
Post-Delivery Support & Maintenance
Product delivery marks not the end of our service, but a new starting point. To ensure your smooth subsequent use, we promise you a comprehensive after-sales service that addresses any specific issues you encounter during your experiments.
Clear Support Channels & Responsive Service
You can reach our technical team via dedicated email, online portal, or direct phone line. We prioritize urgent issues while routine questions get feedback within one business day.
Scenario-Based Technical Guidance
Our troubleshooting ties directly to your workflow. We will promptly adjust and resolve any issues related to our products that you encounter during your current experiments.
Research-Aligned Data Interpretation
We also offer follow-up data interpretation services, where we connect the generated data to your specific research goal. We'll help turn your raw data into meaningful results.
Proactive Long-Term Optimization
We check in regularly with long-term partners. When your research expands, we refine existing models without starting from scratch. Each partner gets a dedicated liaison who learns your workflow, so you never have to repeat details.
Customer Reviews
"Using their liver-kidney-on-a-chip system, we were able to accurately predict the drug-drug interactions. This has saved us a significant amount of time and resources in our drug development program."
- Dr. Emily Johnson, R&D Director at a pharmaceutical company.
"Their cell culture models worked well for our drug testing. The team answered our questions clearly when we had setup issues, and the models held consistent function for the weeks we needed."
— Prof. Michael Torres, Head of Biomedical Engineering Lab
"We used their organ-on-a-chip for a metabolism study. It reduced our need for animal tests as expected, and the data matched our initial hypotheses. The user manual also helped our team get started quickly."
— Dr. Raj Patel, Preclinical Development Lead
"We tried their multi-organ chip system. It took a little time to learn, but their on-site training helped. The system now runs smoothly, and it's made our long-term culture experiments more efficient."
— Dr. Elena Kim, Principal Investigator
"Their patient-derived cell line service met our requirements. The cells retained key functions, which was critical for our personalized treatment research. Communication about delivery timelines was transparent too."
— Mark Taylor, Research Lead
Published Data
Development of organ-on-a-chip system with continuous flow in simulated microgravity
A study developed an OOC model with continuous flow under simulated microgravity. In the research, a simulated microgravity device was combined with the laboratory's proprietary pumping solution to replace syringe pumps. Compared with the continuous flow conditions enabled by the OOC setup, the observed difference was more pronounced.
Fig. 2 Schematic representation of microgravity setup.2,4
Human heart-on-a-chip microphysiological system comprising endothelial cells, fibroblasts, and iPSC-derived cardiomyocytes
In this study, a heart-on-a-chip model was developed by pre-seeding human umbilical vein endothelial cells (HUVECs) in microfluidic channels. The research investigated the effects of culture medium flow—mimicking blood flow in the vasculature—on the morphology and function of endothelial cells. In conclusion, this study has developed a heart-on-a-chip composed of cardiomyocytes, fibroblasts, and vascular endothelial cells.
Fig. 3 Perfusion system for the heart-on-a-chip.3,4
References
-
Wu, Q., Liu, J., Wang, X. et al. "Organ-on-a-chip: recent breakthroughs and future prospects." BioMed Eng OnLine 19, 9 (2020). https://doi.org/10.1186/s12938-020-0752-0
-
Strods, A.; Narbute, K.; Movčana, V.; Gillois, K.; Rimša, R.; Hollos, P.; Rūmnieks, F.; Spule, A.; Mozoļevskis, G.; Abols, A. et al. "Development of Organ-on-a-Chip System with Continuous Flow in Simulated Microgravity." Micromachines 2024, 15, 370. https://doi.org/10.3390/mi15030370
-
Liu, Y., Kamran, R., Han, X. et al. "Human heart-on-a-chip microphysiological system comprising endothelial cells, fibroblasts, and iPSC-derived cardiomyocytes." Sci Rep 14, 18063 (2024). https://doi.org/10.1038/s41598-024-68275-0
-
Distributed under Open Access license CC BY 4.0, without modification.
Created August 2025
FAQs
Q: Can your models be used for long-term studies?
A: Yes, our organ-on-a-chip models can maintain functionality for several weeks, making them fully suitable for long-term culture to investigate the long-term effects of drugs.
Q: Can you use patient-derived cells for organ-on-a-chip models instead of cell lines?
A: Yes, we regularly work with patient-derived cells. It requires extra handling steps but enables personalized testing, crucial for precision medicine research.
Q: Can you customize organ-on-a-chip models based on specific research needs?
A: Yes, we offer customized models. We adjust factors like cell types and channel design to match your research goals, ensuring the model fits your specific study requirements.
Q: Will using your services help reduce the overall cost of our research?
A: Yes. By minimizing the need for animal experiments and streamlining in vitro workflows, our services help cut down on associated costs.
Our cell culture and organ-on-a-chip model development services offer a comprehensive, reliable, and innovative solution for biomedical research. Contact us today to discuss your project and take the first step towards advancing your research goals!
