Microfluidic Chip Development for Nucleic Acids Solution

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In recent years, low-cost nucleic acid solutions on microfluidic chips have been developed, which would become a more valuable platform and one of the most common tools in the biomedical field. Creative Biolabs is a leader in microfluidic chip development. With years of experience and advanced microfluidic platforms, our scientists are pleased to offer the best-qualified outcomes to meet our customers' specific requirements for the development of microfluidic chips.

Microfluidic Chip

Microfluidics chip is often defined as a technology for biomedical and chemical applications, called Lab-on-a-Chip (LOC), which employs a scale of micrometers channels to manipulate small amounts of fluids with the behavior, precise control, and manipulation. Materials used for microfluidic chips can be classified as inorganic materials (such as silica and glass) and organic materials, (such as polydimethylsiloxane (PDMS), polystyrene (PS), polymethyl methacrylate (PMMA), and paper). Microfluidic technologies change the way of biochemistry and biomedical research, make significant improvements in fields of chemical synthesis, drug screening, and organ/tissue modeling.

Microfluidic Chip for Nucleic Acids

Since no complicated instrument is required, microfluidic chip is powerful for nucleic acid detection and analysis in different fields, such as diagnosis of diseases, food safety examination, and environmental pollutant monitoring. The chips now can be fully developed and be integrated with nucleic acid extraction, amplification, and signal detection on a single chip, and further used for point-of-care (POC) identification with sample-to-answer capability. Microfluidic chip enables improved efficiency in analyzing nucleic acids to evaluate the existing state of a specific gene and detailed information such as single nucleotide polymorphism (SNP), insertion, and deletion. Microfluidic technology holds great promise as it can perform typical laboratory operations using a fraction of the volume of reagents in significantly less time.

Isothermal amplification of nucleic acids on microfluidic chips. Fig.1 Isothermal amplification of nucleic acids on microfluidic chips. (Yang, 2019)

Advantage of Microfluidic Chip

Microfluidic technology offers several significant benefits compared to other conventional analysis techniques, such as:

Microfluidic Chip Development for Nucleic Acids Solution

Aiming to fabricate miniaturized systems and analyze at the microscale for nucleic acids solutions, Creative Biolabs can offer the best-fit customized microfluidic chip development with great potential on a small chip to allow for all analytical steps, such as sample separation, mixing, chemical reaction, separation, and detection. We can combine different nucleic acid technologies with microfluidic chips to perform diagnoses in an effective, automatic, high-throughput, and integrated format. Moreover, the optimization of microfluidic chips can also increase the reliability/repeatability of testing for specific requirements such as multiplexed analysis of nucleic acids. Due to unique features of microfluidic chips, it has the potential to significantly improve the development of analytical science in many ways and provide novel solutions to biomedical engineering challenges for diagnostics and therapeutics.

Creative Biolabs now offers the design and development of specific microfluidic chips for different nucleic acid technologies, including but not limited to:

Microfluidic technology has drawn significant attention to be applied to more biological fields in terms of its unique features of reduced sample or reagent consumption, integrated functions, and high portability. By combining the simple, rapid, and specific nucleic acids method with our microfluidic technology, Creative Biolabs offers the high-quality microfluidic chip development service to meet our customers' requirements. Please feel free to contact us for more detailed information.

Reference

  1. Yang, Y.; et al. Microfluidics for Biomedical Analysis. Small Methods. 2019, 1900451.

For Research Use Only. Not For Clinical Use.

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