Custom Flow Photochemistry Chip Services

Creative Biolabs delivers precision-engineered microfluidic platforms purpose-built for light-driven chemical reactions under continuous-flow conditions. Each chip is developed with careful consideration of photon flux uniformity, heat dissipation, mass transfer efficiency, and chemical compatibility.

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Fig. 1 Simplified microfluidic system. (Wei, et al., 2005)

Unlike traditional methods that waste reagents and slow down reactions, microfluidic devices work with minute volumes to boost efficiency and precision—changing the game for researchers and industry professionals alike.

At flow photochemistry chip development service, Creative Biolabs specializes in turning microfluidic potential into real-world solutions. Our focus is simple: design and build custom flow photochemistry chips that make your processes faster, more reliable, and cost-effective.

Service Offerings

Flow photochemistry provides an atomically efficient and attractive method for the synthesis of complex molecules. Creative Biolabs provides cutting-edge flow photochemical reaction chip design, development and processing services for all clients in the fields of chemical synthesis, biology and pharmacy. You will benefit from the multiple advantages of a gentle and defined flow photochemistry process.

Custom Chip Design

We start by listening: What reaction are you running? What are your space or throughput limits? For a pharmaceutical client developing anti-cancer compounds, we designed chips with narrow, light-optimized channels to boost reaction purity. For a materials lab, we created wider microchannels to handle particle synthesis without clogging.

Chip Fabrication

Using proven techniques like photolithography, we create precise microstructures that ensure consistent flow and light exposure. Every chip goes through strict checks: we test for leaks, measure channel dimensions, and run sample reactions to confirm performance.

System Integration

We pair your chip with the right light sources, pumps for steady flow, and detectors to track results in real time. We make sure everything connects seamlessly with your existing lab equipment, so you can start using the system right away.

After-Sales Service

Our support doesn’t end when you receive your chips. We offer:

Support Description
Technical Help A dedicated support team is available via phone or email for setup questions or troubleshooting. We respond to the vast majority of inquiries within a business day.
Training We provide training to help your team get the most out of the system. A recent client said our concise training made their lab techs confident to use the chips immediately.
Maintenance Tips We send regular updates with cleaning guides and best practices to keep your chips working like new.

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Service Applications

Pharmaceutical Industry

Our chips speed up drug development. A major pharma company used our chips to synthesize a key antibiotic intermediate, cutting production time dramatically. For drug screening, our high-throughput chips test numerous compounds at once—helping identify potential treatments faster.

Material Science

We help create better materials. A research team used our chips to make fluorescent polymers for solar panels, achieving a more uniform structure that boosted energy efficiency. Our chips also work for nanomaterial synthesis.

Environmental Monitoring

Our portable chips make on-site testing easy. A water treatment plant uses our devices to detect heavy metals in rivers—getting results quickly instead of waiting for lab samples. For air quality, our chips spot volatile organic compounds (VOCs) rapidly.

Technological Innovations

Smarter Reaction Design

We've developed new ways to run photochemical reactions. For chiral compounds, our chips achieve high purity without expensive purification—saving clients time and money.

Better Microchannel Design

Our hierarchical channels (main channels plus tiny side channels) improve mixing significantly compared to standard chips. This means faster reactions and fewer byproducts.

Real-Time Monitoring

We integrate sensors directly into the chip to track reactions as they happen. A client developing a new pesticide used this feature to adjust flow rates mid-reaction.

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Client Testimonials

"Their custom flow photochemistry chip worked seamlessly for our small-molecule synthesis. The team listened to our reaction needs, and the chip’s light distribution improved our process reliability."

— Dr. Elena Marin, Pharmaceutical Chemist

"We needed a chip for continuous photochemical reactions, and their service delivered a durable, easy-to-integrate product. Technical support helped with setup, ensuring a smooth transition from batch to flow."

— Marcus Bennett, Chemical Process Developer

"Our lab benefited greatly from their tailored chip design. The microchannels optimized reagent mixing, and the chip’s compatibility with our existing equipment saved us time and effort."

— Prof. Clara Wong, Organic Chemistry Research Lead

"Their flow photochemistry chip reduced reagent waste in our production process. The team provided clear operation guidelines, and the chip’s consistent performance met our industrial requirements."

— Nathan Hayes, Fine Chemicals Production Supervisor

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Published Data

Continuous flow photochemistry for the preparation of bioactive molecules

The availability of modern continuous-flow reactors has enabled a wide range of applications, thanks to their more simplified and custom-designed flow processes. Continuous-flow reactors can also be integrated with photochemical reactors—typically based on reactor coils made of various fluorinated polymers, combined with suitable light sources ranging from LEDs to medium-pressure mercury lamps. In this way, continuous-flow processing ensures a uniform irradiation profile without over-irradiating the substrate, which could otherwise cause unwanted side reactions and discoloration of the resulting products. This can be applied to the synthesis of certain bioactive entities, including natural products, pharmaceuticals, and their precursors.

A schematic diagram of a new photo-flow reactor. (OA Literature) Fig.1 Representations of a new photoreactor.1,3

Continuous-flow chemistry and photochemistry for manufacturing of active pharmaceutical ingredients

A study demonstrated an innovative and practical approach for artemisinin synthesis using a continuous-flow process of dihydroartemisinic acid. The continuous-flow system was custom-built in-house, with FEP tubing coiled around a Schenck photochemical reactor equipped with a 450 W medium-pressure mercury lamp cooled to 25 °C. First, porphyrin (TPP)-sensitized flow photooxidation of dihydroartemisinic acid was performed to generate hydroperoxides. This photooxidation step was followed by acid-catalyzed allylic cleavage, triplet oxygen oxidation (under continuous flow with the same conditions), and finally a series of spontaneous condensations, which significantly improved the overall yield of artemisinin.

References

  1. Di Filippo, M.; Bracken, C.; Baumann, M. “Continuous Flow Photochemistry for the Preparation of Bioactive Molecules.” Molecules 2020, 25, 356. https://doi.org/10.3390/molecules25020356
  2. Horáková, P.; Kočí, K. “Continuous-Flow Chemistry and Photochemistry for Manufacturing of Active Pharmaceutical Ingredients.” Molecules 2022, 27, 8536. https://doi.org/10.3390/molecules27238536
  3. Distributed under Open Access license CC BY 4.0, without modification.

Created December 2025

FAQs

Q: What types of photochemical reactions can your flow photochemistry chips support?
A: Our flow photochemistry chips are designed to support a broad spectrum of light-driven reactions, including but not limited to photoredox catalysis, photoinduced oxidation and reduction, photocyclization, photopolymerization, and light-triggered functional group transformations. We routinely accommodate reactions initiated by UV, visible, or near-UV light, and the chip architecture is tailored to match the reaction’s photon absorption profile, solvent system, and kinetic characteristics.
Q: Can your chips accommodate our specific photochemical reaction’s fluid viscosity?
A: Yes. We tailor microchannel design and material selection to match different viscosity requirements. Share your fluid details, and we’ll adjust the chip for smooth flow.
Q: Can the chip design be customized for specific light sources or wavelengths?
A: Yes. All photochemistry chips are custom-designed to integrate seamlessly with your intended light source, whether that involves UV lamps, visible-light LEDs, laser-based systems, or fiber-coupled illumination. We adjust channel geometry, chip thickness, and optical window placement to maximize photon flux at the desired wavelength while ensuring chemical resistance and mechanical stability.
Q: Are your chips suitable for continuous-flow photochemistry in industrial settings?
A: Definitely. We design chips for both lab-scale research and industrial continuous processes, ensuring durability, consistent performance, and compatibility with industrial fluid systems.
Q: What deliverables can clients expect at the end of a chip development project?
A: At project completion, clients receive a fully developed flow photochemistry chip tailored to their reaction requirements, along with detailed design documentation and operating guidelines.
Q: How do clients typically initiate a flow photochemistry chip development project?
A: Projects usually begin with a technical discussion covering the target reaction, light source, solvent system, and desired throughput. Based on this information, we propose a development strategy outlining chip design concepts, timelines, and key milestones.

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Let’s talk about how our flow photochemistry chips can work for you.
Schedule a free consultation today—we’ll discuss your project, answer your questions, and share examples of how we’ve helped clients like you. Whether you need a custom chip or a complete system, we’re here to turn your goals into results.

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