Creative Biolabs offers a robust microneedles fabrication platform built to meet the demanding requirements of modern biomedical research. Our controlled fabrication workflow enables consistent microneedle geometry, reproducible mechanical properties, and adaptable design parameters across multiple batches.
Our microneedle fabrication service is rooted in microfluidic principles, leveraging and enhancing the advantages of miniaturization, integration, and precise control to create microneedle products for diverse fields.
Core Service Offerings
Our fabrication process is engineered to integrate microfluidic design from concept to production, ensuring seamless fluid manipulation and functional integration.
We specialize in designing microneedles as part of integrated microfluidic systems, optimizing every feature for fluid transport efficiency. Using advanced 3D modeling and computational fluid dynamics (CFD) simulations, we tailor:
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Customization
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Description
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Microchannel-integrated structures
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Hollow microneedles with internal lumens of microscale diameter or surface micro/nanogrooves with ultra-fine periodicity to guide fluid flow via capillary action.
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Array configurations
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Needle density optimized for uniform fluid distribution, with prism arrays to enhance capillary-driven transport from macro reservoirs.
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Multiscale fluid paths
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From macroscale reservoirs to microscale channels and nanoscale grooves, creating continuous flow paths that maximize delivery capacity while minimizing skin irritation.
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Our designs adapt to diverse microfluidic functions, including drug loading, sample collection, and real-time sensing—all within a single, compact patch.
Material & Microfabrication Synergy
Material selection is critical to microfluidic-microneedle compatibility, balancing fluidic performance, mechanical strength, and biocompatibility.
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Material
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Description
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Medical-grade materials
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Silicon (for high-precision microchannels), titanium, and biodegradable polymers (PLGA, PCL) that support controlled fluid release and meet relevant biocompatibility standards.
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Microfluidic-optimized polymers
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Soft elastomers and photopolymer resins for moldable microchannels, enabling cost-effective replication of complex flow paths.
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Advanced Fabrication Techniques
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Techniques
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Description
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Soft lithography and photolithography
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For creating high-resolution microchannels and surface nanostructures that enhance capillary flow.
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3D printing (SLA, FDM)
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Direct fabrication of integrated microfluidic-microneedle systems, avoiding bonding steps and enabling rapid prototyping of custom flow paths.
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Deep silicon etching
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For precision microchannel creation in silicon microneedles, ideal for high-pressure fluid delivery or biosensor integration.
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Quality Assurance for Microfluidic Performance
Our quality control goes beyond standard microneedle checks to validate microfluidic functionality.
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Quality Assurance
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Description
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Fluid transport testing
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Measurement of flow rates via established model analysis, ensuring consistent capillary-driven delivery.
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Microchannel integrity
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High-resolution microscopy to verify channel uniformity, absence of blockages, and leak-proof seals.
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Biocompatibility and sterility
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Compliance with global cosmetics and pharmaceutical quality standards, with additional testing for fluid-material compatibility to prevent active ingredient degradation.
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Partner With Us
Key Applications
Chronic disease management: Closed-loop systems for glucose monitoring and insulin delivery, integrating microneedle sensors with microfluidic drug reservoirs.
Diagnostic sampling: Microneedle technology enables painless interstitial fluid collection via hollow microneedles. The microchannels transport samples to on-chip biosensors, facilitating accurate collection and detection of specific disease biomarkers.
Lymphatic targeting: Microneedle technology also enables targeted drug delivery to lymph nodes, which can be achieved through microfluidic patches with multiscale flow paths.
Precision active delivery: Microneedle technology enables uniform distribution and delivery of various functional ingredients to the effective layers of the skin for optimal results.
Customizable formulations: Microfluidic mixing capabilities enable on-patch combination of ingredients, tailoring treatments to individual skin needs.
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Research & Wearable Technology
Lab-on-a-chip integration: Microneedle-microfluidic hybrids for in vitro drug screening and tissue engineering.
Smart wearables: Integration with flexible electronics and wireless communication modules for remote patient monitoring and data-driven care.
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Client Testimonials
"Working with the Microneedles Fabrication Service team streamlined our microfluidic microneedle prototype development. Their attention to material compatibility and fluid flow precision matched our research needs perfectly—reliable and responsive partners."
— Dr. Lila Chen, Biomedical Research Lead
"As a cosmetic brand launching a targeted delivery line, their customizable microneedle arrays delivered consistent performance. The team’s guidance on formulation integration made scaling from sample to production smooth and efficient."
— Mark Reynolds, Product Development Manager
"Their cross-disciplinary expertise solved our drug delivery volume challenge. The microfluidics-driven design ensured uniform active ingredient release, and their flexible order quantities worked well for our early-stage trials."
— Dr. James Harrison, Principal Investigator
"From initial consultation to final delivery, their team maintained clear communication. The microneedles’ structural integrity and flow consistency exceeded our expectations, making them a trusted partner for future projects."
— Sophia Williams, R&D Manager
Published Data
3D printing fabrication process for fine control of microneedle shape
Microneedle electrode (ME) is used to monitor bioelectrical signals by penetrating via the skin, and it compensates for a limitation of surface electrodes. In one study, a novel method using 3D printing is developed to control needle bevel angles. By controlling the angle of printing direction, needle bevel angles are changed. Various angles of printing direction (0–90°) are investigated to fabricate moldings, and those moldings are used for microneedle fabrications using biocompatible polyimide (PI). The height implementation rate and aspect ratio are also investigated to optimize PI microneedles. The result demonstrates that this suggested fabrication can be applied using various polymeric materials to optimize microneedle shape.
Fig.1 The schematic diagram of SLA 3D printing.1,3
A study on the fabrication of metal microneedle array electrodes for ECG detection based on low melting point Bi–In–Sn alloys
One study describes the fabrication and characteristics of microneedle array electrodes (MAEs) using Bismuth–Indium–Tin (Bi–In–Sn) alloys. The MAEs consist of 57 pyramid-shaped needles measuring 340 µm wide and 800 µm high. The fabrication process involved micromolding the alloys in a vacuum environment. Physical tests demonstrated that Bi–In–Sn MAEs have good mechanical strength, indicating their suitability for successful skin penetration. The electrode–skin interface impedance test confirmed that Bi–In–Sn MAEs successfully penetrated the skin.
Fig.2 The contact interface between the skin and the MAE of electrogel in various states.2,3
References
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Jeong, J., Park, J. & Lee, S. "3D printing fabrication process for fine control of microneedle shape". Micro and Nano Syst Lett 11, 1 (2023). https://doi.org/10.1186/s40486-022-00165-4
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Gwak, H., Cho, S., Song, YJ. et al. "A study on the fabrication of metal microneedle array electrodes for ECG detection based on low melting point Bi–In–Sn alloys." Sci Rep 13, 22931 (2023). https://doi.org/10.1038/s41598-023-50472-y
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Distributed under Open Access license CC BY 4.0, without modification.
Created December 2025
