Microfluidic Chip Laser Engraving Services

Creative Biolabs delivers high-precision laser engraving services dedicated to microfluidic chip fabrication, enabling researchers to build complex channel architectures with exceptional accuracy and repeatability. This service can accelerate device development, streamline experimental workflows, and strengthen downstream performance in microfluidic research and engineering.

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Fig. 1 Simplified microfluidic system. (Wei, et al., 2005)

Our Service Portfolio

Creative Biolabs leverages advanced laser systems to deliver core service categories.

Industrial Marking

We provide professional services for microfluidic device manufacturers of all sizes to permanently mark metal, plastic and ceramic surfaces. Using fiber laser technology, we meet relevant industry standards.

Personalized Customization

We offer customized laser engraving services for microfluidic research labs, individual researchers, and small-scale microfluidic enterprises, enabling precise engraving on various microfluidic-specific materials. Simply provide your design concept, or let our professional design team refine your creative vision. Our laser engraving technology guarantees flawless reproduction of tiny, intricate details critical to microfluidic function.

Prototyping & Small-Batch Production

For microfluidic startups or independent researchers developing new microfluidic devices, our service process caters to your need for fast sample delivery. We offer 3D-printed part marking, custom mold engraving for microfluidic chip casting, and small-batch order services to meet your various requirements.

There is no minimum order quantity, supporting you to conduct small-batch production for market demand assessment before scaling up reasonably, making us your ideal choice.

Our Commitment to Innovation

Our laser engraving services stand out as a holistic solution for microfluidic device manufacturing, through cutting-edge technological integration and design flexibility tailored to microscale needs. We leverage advanced manufacturing synergies, combining 3D-printed mold technology with precision microinjection systems to create microfluidic parts with intricate geometries.

Intelligent process monitoring is at the core of our innovation for microfluidics—sensors and data analytics enable real-time adjustment of key parameters like temperature and pressure, minimizing defects and enhancing consistency. We also embrace material innovation, working with high-performance polymers and lightweight alloys that balance strength and functionality, while exploring bionic design principles to optimize microfluidic channel structures for improved fluid flow.

Additionally, our hybrid approach to prototyping and production bridges rapid design iterations with scalable manufacturing, allowing clients to translate lab concepts into tangible microfluidic parts without compromising precision, accelerating time-to-market for new microfluidic devices.

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Applications

Laser engraving has become a cornerstone technique for creating precise and reproducible microfluidic architectures, supporting a wide spectrum of research and engineering scenarios. Creative Biolabs' high-precision laser etching services empower research teams, engineering teams, and product development teams across diverse fields, ensuring each microfluidic chip exhibits exceptional structural integrity and consistency.

Applications	Description
Microchannel Fabrication for Lab-on-a-Chip Devices	Laser engraving enables clean, sharply defined channels ideal for fluid routing, mixing, separation, and controlled transport. It is widely used in the development of lab-on-a-chip platforms where microscale geometry directly determines functional performance.
Single-Cell Manipulation and Analysis Systems	Precise microstructures are essential for trapping, sorting, or dispensing single cells. Engraved patterns offer consistent microenvironments that improve cell viability and enable accurate downstream readouts.
Organ-on-a-Chip and Barrier Models	Customized microchannel geometries enable physiologically relevant perfusion, shear stress control, and compartmentalization—features critical for building organ-on-a-chip, gut-on-a-chip, lung-on-a-chip, and other barrier models.
Droplet Microfluidics and High-Throughput Screening	Laser-defined junctions and flow-focusing regions support reproducible droplet formation, encapsulation, and manipulation, which are essential for high-throughput genetic screening, directed evolution, and single-cell assays.
Chemical and Biochemical Reaction Platforms	Microreactors built via laser engraving offer precise reaction volumes and thermal behavior, enabling high-efficiency chemical synthesis, enzymatic reactions, and kinetic studies at the microscale.
Environmental and Food Safety Analysis	Laser-engraved microchannels allow laboratories to develop portable analysis platforms for contaminants, pathogens, and chemical residues, enabling rapid, on-site sample screening.

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Client Testimonials

"Creative Biolabs' laser engraving service has significantly accelerated our microfluidic prototyping cycle. The channel resolution and edge quality were consistently excellent, allowing us to validate complex fluid behavior with confidence."

— Dr. Laura Nguyen, Senior Microfluidics Scientist

"We were impressed by the precision of the microstructures, especially in multi-layer chip designs. Their engineers communicated clearly throughout the process, ensuring every detail met our experimental requirements."

— James Burton, R&D Engineer

"The quality of the engraved polymer substrates exceeded our expectations. Even at high aspect ratios, the features remained smooth and debris-free, which translated directly into more stable flow performance in our assays."

— Dr. Priya Mehta, Principal Investigator

"As a group working on single-cell manipulation, dimensional accuracy is critical for us. Creative Biolabs delivered chips with outstanding uniformity, enabling us to perform controlled trapping experiments without redesign cycles."

— Michael Anders, Lead Product Developer

"Our organ-on-a-chip research benefited greatly from their custom engraving capabilities. The team understood the nuances of perfusion-based models and provided guidance that improved our overall device layout."

— Dr. Elena Kovács, Assistant Professor of Bioengineering

Published Data

The influence of selected laser engraving parameters on surface conditions of hybrid metal matrix composites

A study analyzed how laser engraving process parameters (such as laser head power and speed) affect surface roughness. The research successfully achieved laser engraving on HMMC composite material surfaces through vacuum infiltration, a process involving liquid metal saturation of porous ceramic-reinforced materials under vacuum conditions. The findings revealed that due to the heterogeneous structure of HMMC materials, complete fusion cannot be achieved with lower laser beam energy. By optimizing beam power and increasing laser head speed, the study demonstrated that reduced surface melting can be obtained, resulting in lower surface roughness and enabling clearer engraving on HMMC surfaces.

Laser engraving diagram. (OA Literature) Fig. 1 The laser engraving process.^1,2

References

Szymański, M.; Przestacki, D.; Szymański, P. "The Influence of Selected Laser Engraving Parameters on Surface Conditions of Hybrid Metal Matrix Composites." Materials 2023, 16, 6575. https://doi.org/10.3390/ma16196575
Distributed under Open Access license CC BY 4.0, without modification.

Created November 2025

FAQs

Q: What materials can be processed through your laser engraving platform?

A: We support a broad range of microfluidic-relevant substrates, including PMMA, PC, COC, COP, PDMS, glass, and selected composite laminates. Our engineers will evaluate each material's optical and thermal properties to determine the optimal engraving parameters for clean, burr-free structures.

Q: How small can the engraved microfeatures be?

A: Typical channel widths reach 20–30 µm depending on the substrate, while depth control remains highly consistent across the patterned area. For applications requiring ultra-fine features, we can fine-tune pulse energy, scan speed, and focus strategy to maximize resolution.

Q: Can you handle multi-layer designs or bonded microfluidic chips?

A: Yes. We routinely engrave structures that will be aligned and bonded in later steps. Our team can provide alignment marks, layer-to-layer registration support, and recommendations for bonding methods to maintain channel geometry and sealing performance.

Q: How consistent is the channel depth and sidewall quality?

A: We employ calibrated pulse modulation and multi-pass control to ensure uniform depth across the microfluidic device. Sidewalls remain smooth, with minimal debris or tapering, which directly supports stable flow behavior and reduces downstream failure rates.

Q: Can the engraved chips withstand downstream biological or chemical assays?

A: Yes. By selecting appropriate substrates and optimizing laser settings, we ensure that the resulting microstructures meet the chemical resistance, optical clarity, and biocompatibility required for fluorescence imaging, cell studies, and biochemical assays.

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Leveraging advanced laser micromachining platforms, we support rapid prototyping, fine-feature patterning, and scalable customization across a wide range of substrates—including polymers, glass, and composite materials.