Microfluidics-Based Analysis in Public Health Monitoring
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At Creative Biolabs, well-designed microfluidic systems can achieve public health monitoring analysis with higher sensitivity, better specificity and fewer reagent requirements.
Microfluidic for Public Health Monitoring
Microfluidic devices provide revolutionary tools for biological diagnostics and industrial applications. Miniaturized microfluidic sensors integrate key steps such as sample collection, separation, and detection into a single chip, and realize automatic and multi-functional analysis. The microfluidic chip is easy to operate, easy to carry, and convenient for on-site deployment, providing a new option for tedious and time-consuming laboratory testing. Microfluidic technology can be further combined with electrochemical, optical, mass spectrometry and other technologies to greatly expand its function and usability. Microfluidic systems have a wide range of applications in public health monitoring, including food safety management, environment monitoring, veterinary diagnostics, organic wastewater treatment, and forensic science.
Fig 1. Pinch flow fractionation (PFF) chip for sample separation. (Zhang, et al., 2021)
Agro-food safety analysis is an important procedure to control food contamination and ensure food safety. A wide range of food safety problems has led people to pay more attention to metal pollution, additive content, pesticide residues, antibiotic abuse and other issues in food with biological toxicity. Traditional detection methods rely on enzyme-linked immunosorbent assay, chromatography or mass spectrometry. The cumbersome inspection and detection process is often unacceptable for foods that require high freshness. Microfluidic chips make up for the shortcomings of traditional methods and provide new possibilities for building a more prioritized on-site, rapid, and accurate food safety control.
Environmental sanitation is related to the safety of surrounding communities and the whole world. The detection and response to environmental pollution will be the constant task of all human beings. Microfluidics can cost-effectively separate and detect multiple parameters in samples from various sources, including heavy metal elements, pathogenic microorganisms or chemical contamination components. The easy-to-operate miniature sensor also provides a detection option with high sensitivity, high specificity and low response time for gas composition and water quality monitoring.
Fig 2. Microfluidic gas sensor. (Kaaliveetil, et al., 2022)
Microfluidic point-of-care analysis has enormous advantages over lab-based tests. Dipsticks and lateral flow microfluidics provide veterinarians or farmers with low-cost, rapid, reliable and field-deployable diagnostic results. Recent advances in microfluidics and the miniaturization of various biological detection principles offer incredible possibilities for veterinary diagnostics, pathogen detection and animal product safety assurance.
In order to meet the increasing demand for water resources, wastewater treatment and recycling has become a key approach to alleviate the shortage of water resources. The microreactor has a higher surface area and volume ratio, which effectively promote mass and heat transfer with better control over the reactive conditions. Microreactors have continuous flow processing capabilities, photocatalytic availability, and reduced safety hazards. These advantages are used to fabricate organic wastewater treatment chips and greatly improve the performance of the reactor.
By miniaturizing and integrating traditional DNA detection methods into microfluidic chips, investigators can collect and analyze samples in real time at crime scenes and rapidly advance detection progress. The sealed channel configuration and in-situ detection principle avoid the risk of cross-contamination greatly. The microliter level's operation accuracy greatly expands the sample analysis's feasibility. In addition, recent advances in biome profiling and transcriptomics also shed new light on the development of microfluidic forensic devices.
Creative Biolabs provides clients from all over the world with the most comprehensive, reliable and flexible one-stop public health monitoring microfluidic system development services. You may directly purchase our well-characterized function chip or organ-on-chips to carry out the project. We also equipped a complete micro-manufacturing platform, you are more than welcome to communicate with our professional engineering team, put forward your requirements or design sketches and entrust us to complete the subsequent development and chip construction for you. Our services will include mold construction for microfluidic chips, fabrication of microfluidic chips with various materials, functionalization and modification of channels, etc. In addition, we also have the ability to complete relevant biological downstream analysis, saving you time for other important work. Please don't hesitate to contact us for more information.
References
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Zhang, X.; et al. Public-health-driven microfluidic technologies: from separation to detection. Micromachines. 2021, 12: 391.
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Kaaliveetil, S.; et al. Microfluidic gas sensors: detection principle and applications. Micromachines. 2022, 13: 1716.
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