Microfluidics system can process small quantities of fluids by using tiny channels with dimensions at the microscale - usually tens to hundreds of micrometers. In the past decade, a number of novel techniques and materials have been applied to microfluidic systems. Meanwhile, integrated microfluidic chips have become powerful platforms for high sensitive, high throughput, and low-cost analysis. With years of experience and advanced microfluidic platforms, Creative Biolabs offers one-stop microfluidic solutions to meet the unique needs of our clients on microfluidic integrated devices.
Introduction
Bioanalysis is a crucial part of biomedical analysis, which mainly includes two parts, biological system analysis and biomolecular detection. In the recent years, scientists focus on three areas: 1) integration and miniaturization of analytical devices for point-of-care (POC) testing, 2) analyzing at single-cell or single-molecule level to obtain critical information about the heterogeneity of certain population, as well as 3) high-throughput screening for large-scale analysis. In order to solve these problems, microfluidic techniques are under rapid development, which revolutionize the way for sampling, sample separation, mixing, chemical reaction, and detection.
Fig. 1 Simplified microfluidic system.1
Microfluidic is also called laboratory on a chip (LOC). Since development, microfluidic technologies have revolutionized the way for experimental biology and biomedical research, along with significant improvements in fields of chemical synthesis, biofabrication, drug screening, and organ/tissue modeling. Importantly, microfluidics can integrate with POC testing to achieve high sensitivity, portability, and specificity. Recently, the application of microfluidic devices in the bioanalytical field has grown rapidly, such as achieving the “sample-in/result-out” analysis mode, precisely tuning the size and pattern of nanoparticles for drug delivery, as well as discovering and screening new chemical entities.
Preparation of Microfluidic Chip
Usually, a microfluidic chip is composed of distinct compartments of inlet, channel mixer, and signal detector. Nowadays, the development of micro-/nanofabrication techniques eases the manufacturing of individual microfluidic component, which will then be assembled to make a functional chip. To date, several materials can be used in microfluidic chips, including organic materials (e.g., polydimethylsiloxane, or PDMS, polystyrene, or PS, polymethyl methacrylate, or PMMA, and paper), inorganic materials (e.g., silica and glass), and composite materials.
Fig. 2 Body on a chip system.2
Advantages of Microfluidic Systems
Very low volumes of samples and reagents
Cost-effective and competitive price
High-throughput analysis can run multiple reactions simultaneously
Shorter analysis times and faster results
High resolution and sensitivity in the detection and separation
With Ph.D. level scientists and over a decade of experience in microfluidic systems, Creative Biolabs is dedicated to serving the unique needs of our clients by providing services that are tailored to meet your R&D timeline and budget. Please contact us for more information and a detailed quote.
References
Wei, Cheng, et al. " Using a microfluidic device for 1 microl DNA microarray hybridization in 500 s." Nuleic Acid Res 12.33 (2005): e78.
Perastrelo, Aguas, et al. " Microfluidic Organ/Body-on-a-Chip Devices at the Convergence of Biology and Microengineering." Sensors 15.12 (2015): 31142-31170.
Q&As
Q: What types of microfluidic devices can be developed through this service?
A: Our service offers a diverse range of microfluidic devices, such as chips, pumps, mixers, and droplet generators, designed with precision and reliability in mind. These devices enable precise manipulation of fluids and particles, facilitating various applications including cell culture, drug screening, and biochemical analysis.
Q: How can the One-Stop Microfluidic Solutions service benefit our drug development research?
A: By utilizing our service, researchers gain access to customized microfluidic devices optimized for their specific experimental requirements. These devices enhance experimental efficiency, enabling high-throughput screening, controlled drug delivery, and advanced analysis techniques, ultimately accelerating the pace of drug discovery and development.
Q: Can you provide examples of successful applications of your microfluidic solutions in drug development?
A: Our microfluidic solutions have been instrumental in various drug development applications, including high-throughput screening of compound libraries, controlled drug delivery systems, and microscale tissue engineering platforms. These applications demonstrate the versatility and effectiveness of our tailored microfluidic devices.
Q: How does your One-Stop Microfluidic Solutions service ensure quality and reliability?
A: We adhere to stringent quality control measures throughout the design, fabrication, and testing phases of our microfluidic devices. Our team of experts utilizes advanced fabrication techniques and rigorous testing protocols to ensure that each device meets the highest standards of performance and reliability.
Q: What level of expertise and support can we expect from your team throughout the project?
A: Our team consists of experienced microfluidics specialists who are dedicated to providing comprehensive support and guidance throughout the project lifecycle. From initial consultation to device optimization and troubleshooting, we are committed to ensuring a seamless and successful collaboration with our clients.
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Creative Biolabs has established a comprehensive microfluidics technique platform.
Fig. 1 Simplified microfluidic system.1
Fig. 2 Body on a chip system.2
