Custom Silicon Microfluidic Chip Design and Fabrication
With years of expertise in this field, Creative Biolabs can provide customized solutions for your microfluidic projects through silicon-based microfluidic chip manufacturing services. Our silicon microfluidic platforms are ideal for advanced chemical synthesis, high-temperature reactions, integrated sensing, and system-level lab-on-a-chip development.
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Silicon-based microfluidic chips remain the gold standard for applications demanding precise flow regulation, superior mechanical robustness, and seamless integration with electronic or optical components. Creative Biolabs supports researchers and developers with customized silicon microfluidic chip solutions, covering layout optimization, microchannel engineering, surface treatment, and hybrid integration. Our platform enables stable and reproducible microfluidic performance for analytical chemistry, biosensors, and next-generation microphysiological systems.
Service Offerings
Every research project and industrial application has unique microfluidic requirements, and our customization service is engineered to address this diversity.
We specialize in fabricating silicon chips with microchannel widths spanning ultra-fine to relatively large dimensions to refine complex structures like Y-type separators, 3D interconnected channels, and integrated microelectrode arrays with exceptional edge definition.
Typical custom solutions include dPCR chips for liquid biopsy, microreactor chips for chemical synthesis, and cell manipulation chips.
High-Quality Standard Chip Production
For clients requiring rapid deployment of microfluidic systems and consistent performance, our portfolio of standard silicon microfluidic chips—manufactured for uniform microchannel fabrication—offers a cost-effective alternative.
These chips adhere to international quality standards, ensuring minimal variation in channel uniformity and ultra-fine surface finishes.
Our standard product line includes general-purpose fluidic chips for routine microfluidic analysis, sample preparation chips for environmental monitoring, and detection chips compatible with common lab equipment.
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Service Advantages
Advanced Manufacturing Capabilities
Our production facility is equipped with state-of-the-art microfabrication equipment, including deep reactive ion etching (DRIE) systems, double-sided lithography tools, and magnetron sputtering equipment. We enable higher integration and smaller footprints for compact microfluidic devices.
End-to-End Expert Support
Our team comprises microfabrication engineers, material scientists, and application specialists with extensive industry experience. For clients new to silicon-based microfluidics, we offer free technical consultations to identify the most suitable processes for your specific microfluidic needs.
Rigorous Quality Assurance
Quality is embedded in every step of our microfluidic chip fabrication process. We source high-purity silicon wafers from certified suppliers systems calibrated for microfluidic requirements, paired with in-line inspections via scanning electron microscopy (SEM) and optical profilometry.
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Material Comparison
Choosing the right material is critical for microfluidic chip performance, and silicon’s unique properties make it indispensable for high-demand scenarios. Here’s how it compares to other common materials in microfluidic applications.
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Material
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Comparison
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Silicon vs. PDMS
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While PDMS is popular for lab-scale microfluidic prototyping due to low cost, silicon offers vastly superior mechanical strength and thermal conductivity—ideal for high-pressure/temperature microfluidic setups.
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Silicon vs. Glass
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Glass excels in optical transparency for microfluidic detection, but silicon enables seamless integration with CMOS electronics—critical for smart, miniaturized microfluidic devices.
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Silicon vs. Thermoplastics
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Silicon outperforms them in chemical resistance (withstanding harsh reagents) and precision—made more reliable to create consistent microchannel dimensions, making silicon the top choice for trace analysis and harsh-conditions microfluidics.
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Application Areas
Our silicon microfluidic chips for robust microchannel structures support real-time detection of water contaminants, air pollutants, and soil toxins.
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Chemical & Pharmaceutical Research
In drug development and chemical synthesis, silicon-based microfluidic chips enable high-throughput screening of reaction conditions, precise controlled-temperature reactions, and efficient reagent mixing.
The global microfluidic chip market is projected to grow substantially in the coming years, with silicon-based solutions playing a critical role in high-end applications. Key trends driving growth include the integration of microfluidics with CMOS electronics (smart chips) and the rise of point-of-care (POC) devices.
Our service aligns with these trends, focusing on microfluidic miniaturization, integration, and cost optimization. We are actively developing hybrid silicon-polymer microfluidic chips.
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Customer Reviews
"We rely on their standard chips for environmental monitoring projects across Asia. The consistency and durability of their products have significantly reduced our equipment downtime."
— Michael Zhang, Operations Director
"The technical support team’s expertise in silicon etching was invaluable. They helped us optimize our chip design for high-pressure applications, which our previous supplier couldn’t achieve."
— Sarah Johnson, R&D Manager
"Their silicon chips maintained stable performance in our long-term cell culture tests. The team’s prompt response to our design adjustments made the collaboration smooth and efficient."
— Dr. Mark Lewis, Biomedical Researcher
"We integrated their standard chips into our environmental detectors. The consistent channel quality ensured reliable data, which helped us meet regulatory reporting requirements easily."
— Lisa Wang, Product Manager
Published Data
Ultrafast nucleic acid detection equipment with silicon-based microfluidic chip
An ultrafast polymerase chain reaction (PCR) equipment is designed to detect virus. The equipment consists of a silicon-based PCR chip, a thermocycling module, an optical detection module, and a control module. Silicon-based chip, with its thermal and fluid design, is used to improve detection efficiency. A thermoelectric cooler (TEC), together with a computer-controlled proportional–integral–derivative (PID) controller, is applied to accelerate the thermal cycle. A maximum of four samples can be tested simultaneously on the chip. Two kinds of fluorescent molecules can be detected by optical detection module. The equipment can detect viruses with 40 PCR amplification cycles in 5 min.
Fig.1 Schematic diagram of the microfluidic chip.1,2
References
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Zhang, Jiali, et al. "Ultrafast nucleic acid detection equipment with silicon-based microfluidic chip." Biosensors 13.2 (2023): 234. https://doi.org/10.3390/bios13020234
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Distributed under Open Access license CC BY 4.0, without modification.
Created December 2025
FAQs
Q: In which applications are silicon microfluidic chips the preferred choice?
A: Silicon microfluidic chips are typically selected for applications where precision, reproducibility, and system integration are critical. These include high-temperature or high-pressure microreactors, integrated chemical synthesis platforms, MEMS-based sensing systems, electrophysiological devices, and
microfluidic platforms requiring tight coupling with electronic or optical components. When experimental robustness and data consistency are prioritized over rapid prototyping flexibility, silicon-based chips often become the preferred solution.
Q: Can silicon chips be used for fluorescence detection?
A: While silicon is opaque to visible light, we offer hybrid chips with glass coverslips bonded via anode bonding, enabling fluorescence imaging without compromising silicon’s performance.
Q: Can your chips be integrated with our existing lab equipment for biological sample analysis?
A: Yes, we design chips with compatible interfaces to fit common lab setups. Our team can also adjust designs slightly to match your specific equipment requirements.
Q: Can Creative Biolabs provide fully customized silicon microfluidic chip designs?
A: Yes. Creative Biolabs offers fully customized silicon-based microfluidic chip development tailored to specific functional and integration requirements. Our services cover chip layout design, microchannel architecture optimization, feature size definition at the micro- and nano-scale, and compatibility planning with downstream systems.
Q: Can silicon microfluidic chips be integrated with other materials or systems?
A: Absolutely. Silicon microfluidic chips are highly compatible with hybrid integration approaches, including bonding with glass substrates, incorporation of metal electrodes, and coupling with optical or electronic components. This makes them well suited for advanced lab-on-a-chip systems, sensor platforms, and multifunctional microfluidic devices. Creative Biolabs supports integration planning as part of the chip development process to ensure seamless system-level performance.
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Our silicon-based microfluidic chip fabrication service is your trusted partner. Contact us today for a free technical consultation and customized proposal. Let’s collaborate to push the boundaries of what’s possible with silicon-based microfluidics.
