Equipped with complete microfluidic system fabrication equipment and well-trained staff members, Creative Biolabs provides our clients worldwide with a one-stop solutions service for glass microfluidic chip fabrication. Ready-to-use microfluidic chips are also available, we believe you can find a suitable chip to meet your requirement.
Glass microfluidic chips are increasingly gaining prominence in the microfluidic field due to their remarkable properties. These chips are characterized by excellent chemical resistance, enabling them to support organic solvents and acid/alkaline reagents. Further, glass microfluidic chips have undergone extensive surface modification procedures, resulting in the formation of a simple, comprehensive, and well-characterized bio-covalent coupling scheme.
Fig 1. A design of all-glass chip. (Peng, et al., 2016)
Advantage
Glass microfluidic chips possess high optical transparency, low background fluorescence, and exceptional mechanical strength, which allow them to withstand high channel pressure. They are also renowned for their outstanding thermal stability and resistance to high temperatures. Glass has hydrophilic surface properties, which prevent the diffusion of small molecules from the channel. In addition, its high resistivity makes it ideal for high-voltage electrophoresis separation.
Disadvantage
While glass works well as a substrate for many biochemical experiments, its disadvantages should be taken into account when selecting materials for microfluidic systems. Glass has virtually no toughness, making it prone to breakage on impact. Etching produces channels with irreversible circular features. Glass chip processing requires complex and specialized equipment and cannot be rapidly prototyped in a laboratory environment after receiving molds.
Creative Biolabs has made significant strides in the development of fully and semi-automated techniques for the mass production and rapid prototyping of glass microfluidics. This innovation addresses the need for glass microfluidic system manufacturing and development, thereby enabling the achievement of high precision and expeditious production of glass chips. You can get more information on our glass chips page, and please contact us directly to discuss your needs with an expert.
Reference
Wlodarczyk, Hand, et al. " Maskless, rapid manufacturing of glass microfluidic devices using a picosecond pulsed laser." Nature Portfolio 9.1 (2019): 20215.
Product Overview: The Herringbone Microfluidic Chip significantly accelerates the mixing in the low Reynolds number regime by inducing the formation of chaotic flows. It contains a specific pattern with asymmetric herringbone shaped grooves on its bottom which is able to produce helical flow and chaotic stirring for mixing two liquids. It can be used for mixing liquids and for liposomes production.
Product Overview: Our double emulsion microfluidic chip, incorporating localized modifications and a classic flow-focusing structure, is specifically designed to generate stable and uniform double emulsion droplets. The glass construction of the chip ensures enhanced durability, thermal stability, and enables operation under high-pressure conditions. Based on your specific experimental requirements, we offer standard chip versions with nozzles of different sizes. It is important to note that the resulting droplet size will vary depending on your specific experimental setup. The size of the nozzles plays a crucial role in determining the size of the generated droplets.
Product Overview: We currently offer a range of standardized microfluidic droplet generation chips. Compared to commonly used PDMS chips, glass chips provide higher durability and thermal/chemical stability. Glass also have lower fluorescence background, enabling seamless integration with various fluorescence detection methods. These chips can be hydrophobic or hydrophilic modified to accommodate different droplet production needs. Depending on your experimental setup, our chips can generate uniform droplets ranging from 30 to 200 microns in size.
Fig 1. A design of all-glass chip. (Peng, et al., 2016)
