Micro-injection Casting Services

Casting and microinjection services are critical for fabricating microfluidic chip components (e.g., microchannel molds) and enabling precise reagent/cell delivery in microfluidic systems. Creative Biolabs' services are used in cell biology, molecular biology and model organism research, serving as a key link between microfabrication and biological manipulation for lab-on-a-chip technologies.

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Fig. 1 Simplified microfluidic system. (Wei, et al., 2005)

Our Core Services

Casting Solutions

We offer end-to-end casting services tailored to specialized support for microfluidic device manufacturing, including:

Precision Metal Casting

We provide ultra-precision casting for various types of metals—ideal for producing microfluidic system components like leak-proof manifolds, microvalve bodies, or chip frames that require tight tolerances for fluid control.

Biocompatible Molding

We can manufacture custom molds tailored to laboratory needs, —specifically supporting microfluidic use cases like casting with materials based on your requirements to meet your diverse applications.

Rapid Prototyping

Our pre-production prototyping is fast—such as rapid fabrication of microfluidic chip housing prototypes or microchannel mold samples to test flow compatibility.

Micro injection Expertise

Our micro-injection casting service enables high-precision fabrication of micro-scale structures with exceptional dimensional accuracy and reproducibility.

Controlled Injection Parameters

Leveraging advanced micro-mold machining and controlled injection parameters, this service supports the rapid production of microfluidic chips, organ-on-chip components, and complex microstructured devices.

Material Compatibility

The process accommodates a wide range of polymers and biocompatible materials, ensuring excellent structural fidelity, smooth channel surfaces, and strong material stability for downstream biological or engineering applications.

Scalable Manufacturing

Designed for projects requiring repeatable quality and scalable manufacturing, the service provides a reliable pathway from prototype development to consistent small- or medium-batch production under rigorous quality control.

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Service Advantages

High-fidelity Replication of Microfeatures

Micro-injection casting enables high-precision replication of structures at the micrometer and submicrometer scales, ensuring complete consistency in shape, dimensions, and surface quality for features such as microfluidic channels, microcavities, and microcolumn arrays.

Exceptional Repeatability and Batch Consistency

Automated injection and curing control ensure consistent chip quality across every batch, making it ideal for R&D projects and industrial validation requiring strict repeatability.

Customization

We can adjust the process flow according to your requirements—including microfluidic-specific customizations, such as modifying casting molds to match microchannel dimensions or tuning injection parameters for samples in microfluidic chambers.

Strengthened Structural Integrity

The molded components exhibit enhanced mechanical strength, pressure resistance, and chemical stability, enabling them to withstand complex fluid operations and prolonged experimental conditions.

Streamlined Service Process

Service Process Description
Design Consultation & Mold Engineering Our technical team performs structural design and simulation analysis based on client requirements for microstructures, material selection, and application needs, then customizes metal or micro-machined molds.
Material Preparation & Injection Parameter Setup Injection temperature, pressure, rate, and holding pressure strategies are set according to target material properties (e.g., melting point, viscosity, solidification speed) to ensure molding precision and internal structural stability.
Micro-Injection Casting & Controlled Solidification Material injection, uniform filling, and rapid solidification are performed within a precision injection system to ensure complete formation of microchannels and complex geometries without voids or deformation.
Demolding & Structural Integrity Inspection Microstructural damage is minimized through refined demolding techniques. Molded parts undergo dimensional measurement, surface roughness evaluation, and packaging compatibility checks.
Surface Treatment & Optional Bonding Optional processes include plasma treatment, surface coating, channel modification, or multi-layer device bonding and encapsulation based on application requirements.
Final QC & Delivery Strict QC procedures verify functional structures, optical properties, pressure tolerance, and batch-to-batch consistency, delivering ready-to-use microfluidic devices.

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Applications Across Industries

  • Microfluidic Chip Prototyping and Optimization

Enable rapid iterative prototyping of microchannels, separation zones, and mixing units for fluid behavior validation and performance optimization.

Suitable for constructing chip substrates with precise geometry and optical transparency, supporting complex systems such as cell co-culture, barrier models, and vascular models.

Utilize high-precision microstructures for single-cell capture, manipulation, and analysis, ideally suited for integrating high-throughput screening or micro-reaction systems.

  • Drug Screening and Pharmacokinetic Modeling

Customizable multi-compartment or gradient structures provide stable micro-scale platforms for studying drug absorption, metabolic behavior, and microenvironmental responses.

  • Environmental & Chemical Microreactors

Stable and reliable microreactor structures for chemical reaction kinetics, environmental monitoring, and continuous flow system development.

  • Diagnostic Device Manufacturing

Enable mass production of point-of-care (POC) microdiagnostic devices, including reagent reaction chambers, mixing units, and detection windows.

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Client Testimonials

"Channel dimensions were consistently accurate across multiple batches, which significantly reduced our troubleshooting time. The team responded quickly to design adjustments and delivered every prototype on schedule."

— Jake Bennett, Product Development Manager

"We relied on Creative Biolabs to fabricate a series of complex microfluidic structures for organ-chip testing. The clarity, surface finish, and bonding compatibility were excellent. Their engineering team helped us refine our design and improve device stability."

— Maria Gonzalez, Quality Manager

"Our project required small-batch, high-precision polymer chips with tight tolerances. The micro-injection casting service provided reliable replication and solid mechanical strength. The consistent results streamlined our downstream flow characterization work."

— Dr. James Wei, Senior R&D Scientist

"We needed custom polymer casts for our microfluidic chips. They listened to our requirements, provided sample prototypes first, and the final casts matched our design perfectly. Communication was smooth throughout."

— Jake Bennett, Product Development Manager

Published Data

Microinjection molding processing parameters on replication quality of polylactic acid microneedle array product

This study designed a microinjection mold to fabricate a biodegradable polylactic acid (PLA) in-plane microneedle array product. In order to ensure that the microcavities could be well filled before production, the influences of the processing parameters on the filling fraction were investigated. The results indicated that the PLA microneedle can be filled under fast filling, higher melt temperature, higher mold temperature, and higher packing pressure, although the dimensions of the microcavities were much smaller than the base portion. We also observed that the side microcavities filled better than the central ones under certain processing parameters.

Actual mold and product. (OA Literature) Fig.1 Injection molding mold, eventual product, and single microneedle array product.1,2

References

  1. Yu, Wenqian, et al. "Study on the influence of microinjection molding processing parameters on replication quality of polylactic acid microneedle array product." Polymers 15.5 (2023): 1199. https://doi.org/10.3390/polym15051199
  2. Distributed under Open Access license CC BY 4.0, without modification.

Created November 2025

FAQs

Q: What level of dimensional accuracy can micro-injection casting achieve?

A: Our process typically maintains micro-scale dimensional tolerances within a few microns, depending on feature complexity and material type. Each project undergoes mold calibration and injection parameter optimization to ensure structural precision and repeatability.

Q: Which materials are compatible with your micro-injection casting platform?

A: We support a wide range of thermoplastics and functional polymers, including PMMA, PC, COC, COP, PLA, and other biocompatible or optically transparent materials. Material recommendations are based on your application needs, fluid behavior, and downstream bonding strategies.

Q: Can you fabricate multi-layer microfluidic chips?

A: Yes. We offer optional bonding services such as thermal bonding, solvent bonding, and plasma-assisted bonding. This allows us to build multilayer devices with complex channel networks, gradient generators, or integrated reaction chambers.

Q: Do you provide guidance on material selection for specific applications?

A: Absolutely. We evaluate chemical resistance, biological compatibility, optical properties, and mechanical strength to recommend the most suitable polymers for your microfluidic or micro-device application.

Q: Can you use the materials we provide for casting instead of your standard options?

A: We can use your supplied materials. We'll first check their compatibility with our processes to ensure the final parts meet your expectations.

Q: Can micro-injection casting support biologically relevant chips, such as organ-on-chip systems?

A: Yes. The technique is well-suited for organ-on-chip and cell-based devices due to its high transparency, smooth channel walls, and stable mechanical properties. We can also integrate cell-culture-friendly coatings or surface activation options if required.

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Ready to transform your preclinical research? Get a Quote Now

Our micro-injection casting services deliver highly consistent structural replication and material compatibility, ensuring models maintain stable performance during functional validation and in application scenarios.

Contact our team today for a free consultation.

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