Microfluidic Organ-on-a-Chip Platform

Creative Biolabs provides a full range of state-of-the-art organ-on-chip services, crafted to help you launch and advance your research projects smoothly. We’ve focused exclusively on organ-on-chip research, development, and applications. Our diverse products are now used by pharmaceutical companies worldwide.

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Fig. 1 Simplified microfluidic system. (Wei, et al., 2005)

An organ-on-chip cell culture platform is an advanced microfluidic technology that uses living cells, biomimetic matrices, and dynamic microenvironments to replicate the structural, functional, and physiological traits of human organs/tissues in vitro. If you're looking to run microfluidic cell experiments but aren't sure how to get started, our custom cell culture platforms are here to offer the perfect solution.

Functions of the Organ-on-Chip Cell Culture Platform

The organ-on-chip cell culture platforms replicate critical in vivo traits, like tissue structure, cell-to-cell interactions, mechanical forces (such as fluid shear and cyclic stretch), and biochemical gradients, allowing for more accurate modeling of organ-level responses than traditional 2D cultures or animal models.

Introduction of organ-on-chip model. (OA Literature) Fig.1 The application of organ-on-chip model.^1,4

Service Portfolio

We provide leading organ-on-chip services, delivering end-to-end solutions specifically engineered to accelerate biomedical innovation. Its core offerings encompass the following:

Services	Descriptions
Custom Organ Chip Design	Custom-designed models of the lung, liver, neurovascular system, and multi-organ systems—each fine-tuned to replicate tissue-specific microenvironments, such as alveolar-capillary interfaces with their natural physiological stretch.
Cell Sourcing & Validation	Access to thoroughly characterized primary cells, iPSCs, and co-culture systems—backed by validation protocols that ensure phenotypic stability for four or more weeks in culture.
Advanced Microfluidic Cultivation	Long-term maintenance using industry-leading platforms enabling precise control of shear stress, oxygen gradients, and nutrient perfusion.
Downstream Analytics	Integrated services cover permeability assays, immunofluorescent imaging, cytokine profiling, and real-time metabolic monitoring.

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Service Advantages

The organ-on-a-chip technology offered by our platform is far superior to traditional models. Choosing our platform is predicated on the following advantages it possesses:

High Accuracy - Our organ-on-chip systems replicate dynamic biological interaction. By simulating the overall physiological environment, it can significantly enhance the accuracy of drug metabolism predictions, particularly in the research of drug metabolism.
High Efficiency - Organ-on-a-chip platforms can shorten preclinical timelines by enabling early detection of drug failures and reduce unnecessary investments. Additionally, these systems lower the dropout rate of late-stage clinical trials.
Productivity - The use of multi-organ-on-a-chip provided by our platform significantly reduces reliance on animal model, thereby accelerating research progress.
Scalability - High-throughput platforms can screen over 1,000 compounds, making organ-on-chip technology practical for large-scale drug discovery.

Accelerate your research progress—our team of experts stands ready to provide support.

Service Workflow

From the initial consultation on your concepts, through the implementation of experiments, to the delivery of visualized results, our company provides end-to-end support to ensure a seamless and worry-free experience for you.

Discovery Consultation

Work with our scientific team to outline your goals—like NASH drug screening or neurodegeneration modeling—and craft a customized experimental plan that fits your needs.

Chip Fabrication & Optimization

We’ll engineer chip architectures using biofunctionalized matrices—such as laminin-coated membranes for lung models—and validate microfluidic parameters to replicate in vivo conditions.

Cell Seeding & Maturation

We use our proprietary protocols to drive tissue-specific differentiation and functional maturation, with perfusion fine-tuned to recreate the physiological shear stress of the body.

Data Capture & Analysis

We use advanced sensing technologies and high-resolution imaging to gather quantitative data, paired with expert analysis that uncovers key mechanistic insights—like drug transport kinetics or cellular crosstalk.

Customized Reporting

You’ll receive comprehensive reports featuring raw data, statistical analyses, contextual interpretations, and iterative adjustments to help refine results.

One-stop Microfluidic Solutions Brochures

The Microfluidic Platform by Creative Biolabs offers one-stop solutions for advanced microfluidic system development, integrating cutting-edge design, prototyping, and analysis to meet diverse research and diagnostic needs efficiently. Submit the form below to download this brochure!

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Applications

Drug Development

Liver-on-chip models supported the provision of critical data for clinical drug candidates to advance into Phase I trials for non-alcoholic steatohepatitis (NASH).

Disease Modeling

Neurovascular chips enable research on metabolic coupling between endothelial cells and neurons, offering possibilities for unraveling novel mechanisms in ALS.

Precision Oncology

Tumor chips made from patient-derived cells predict chemotherapy responses with high accuracy in colorectal cancer cases, helping to guide personalized treatment plans.

Infectious Diseases

Lung-on-a-chip models that meet specific biosafety level standards accelerate research on viral transmission and aid in the screening of antiviral drug candidates for subsequent clinical evaluation.

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Client Testimonials

"Their model enabled us to replicate idiopathic pulmonary fibrosis pathophysiology with unprecedented fidelity, revealing drug targets missed by animal models."

—Dr. Rajiv Mehta, Preclinical Lead

"As a startup, we needed reliable OoC data fast. Their custom neuron chip delivered consistent results, and their team walked us through every step. Worth every penny for early-stage validation."

—Lila Chen, R&D Director

"Their kidney-on-chip model revealed a drug interaction we'd missed in 2D tests. Avoided a costly late-stage failure."

—Dr. Priya Nair, Toxicology Head

"Scaling our cancer research required high-throughput OoC tools. Their multi-organ platform handled 50+ samples daily with precise data, keeping our lab on track for publication."

—Prof. James Ortiz, Principal Investigator

Published Data

Analyze angiogenic effects of MSC co-cultured on the microvessel on a chip system

In a study, researchers designed a microvascular microchip model for the co-culture of mesenchymal stem cells (MSCs) with human umbilical vein endothelial cells (HUVECs). Through the co-culture system established on the chip, the newly formed mesenchymal stem cells exhibited more mature morphological characteristics. Building on this, the research team was able to further explore the specific mechanisms and spatiotemporal behavioral patterns of mesenchymal stem cells during angiogenesis.

Fig.2 Related results of organ-on-a-chip in the exploration of CVDs pathogenesis.^2,4

Organ-on-a-chip's role as a "gold standard bridge" between organoids and in vivo models for Parkinson's.

A study constructed a "human-on-a-chip" multi-organ model by connecting seven organ chips (brain, pancreas, liver, lung, heart, intestine, and endometrium). Using this model to study the metabolism of tolcapone, a drug for Parkinson's disease, in the human body, researchers successfully identified three new metabolites and revealed the associations between significant changes in key biomarkers in the brain organ chip and specific metabolic disorders.

OoC’s role as a gold standard bridge between organoids and in vivo models.(OA Literature) Fig.3 Schematic diagram of the "human-on-a-chip" system simulated on the microfluidic chip.^3,4

References

Zhu, J. et al. "Application of Organ-on-Chip in Drug Discovery." Journal of Biosciences and Medicines, 8, 119-134. https://doi.org/10.4236/jbm.2020.83011.
Jing Liu, Ying Wang, et al. "Advances in organ-on-a-chip for the treatment of cardiovascular diseases."MedComm-Biomater Appl. 2023; 2:e63. https://doi.org/10.1002/mba2.63
Wysoczański B, Świątek M, Wójcik-Gładysz A,et al. "Organ-on-a-Chip Models—New Possibilities in Experimental Science and Disease Modeling. "Biomolecules. 2024; 14(12):1569. https://doi.org/10.3390/biom14121569
Distributed under Open Access license CC BY 4.0, without modification.

Created August 2025

FAQs

Q: How long does it take to set up your liver-on-chip system for our hepatotoxicity studies?

A: It takes only a few days, and the setup primarily involves cell seeding and equilibration. We will provide you with a step-by-step protocol, and our technical team will offer real-time support to ensure optimal functionality from the very first day after setup.

Q: Can your platforms accommodate primary human cells instead of cell lines?

A: Absolutely. Our systems are optimized for primary cells, with adjustable microfluidic flow that mimics in vivo conditions—key for studies needing physiological relevance, like personalized medicine research.

Q: Do you offer customization for multi-organ interaction studies—like liver-kidney crosstalk?

A: Yes. We can integrate organ modules with interconnected microchannels, all tailored to your specific crosstalk pathways. Custom orders typically take more time to complete.

Q: How does your data analysis software work with standard lab tools?

A: Our software exports data works seamlessly with Excel, GraphPad, and Prism. It also generates both raw and processed datasets, making statistical analysis workflows much smoother.

Accelerate Your Research

Ready to transform your preclinical research? Get a Quote Now

Reach out to our team today to book a consultation, talk through your specific goals, and find out how our organ-on-chip platform can deliver faster, more reliable results—cutting costs, speeding up timelines, and fueling the breakthroughs that count.

Your next scientific breakthrough starts here.