Microfluidic encapsulation replaces stochastic mixing with deterministic physics—laminar flow, interfacial tension control, and real-time parameter tuning—delivering reproducibility by design. Built on advanced droplet microfluidics and flow-focusing architectures, our platforms enable deterministic control over particle size, composition, release kinetics, and payload distribution—at single-cell and single-droplet resolution.
Whether your goal is to preserve viability, enhance stability, enable targeted delivery, or standardize high-throughput screening, Creative Biolabs' microfluidic encapsulation solutions are designed to de-risk development and accelerate translation.
Service Portfolio Overview
Our cell encapsulation workflows are optimized for single-cell isolation, 3D culture, immune-cell engineering, and regenerative research. By precisely tuning gelation kinetics and shear profiles, we preserve phenotype, viability, and functional outputs.
Proteins demand gentle handling and controlled microenvironments. Our microfluidic protein encapsulation minimizes interfacial stress and aggregation while enabling sustained or stimuli-responsive release.
We engineer enzyme microcapsules that retain catalytic activity while improving reusability and operational stability—ideal for biocatalysis, biosensing, and flow chemistry.
Microfluidic encapsulation enables single-bacterium confinement, controlled growth, and protection from environmental stress—critical for microbiology, synthetic biology, and probiotic R&D.
Our virus encapsulation services focus on maintaining structural integrity and infectivity (where applicable) while enhancing handling safety and experimental reproducibility.
We support multi-species co-encapsulation, enabling controlled interaction studies within defined microenvironments—an essential tool for microbiome mechanism-of-action research.
For poorly soluble or unstable APIs, microfluidic encapsulation offers uniform loading, enhanced dissolution profiles, and precise release modulation.
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Payload Type
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Primary Objectives
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Typical Outputs
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Cells
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Viability, clonality, protection
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Single-cell microgels
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Proteins
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Stability, sustained release
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Uniform protein microcapsules
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Enzymes
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Activity retention, reuse
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Enzyme-loaded beads
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Bacteria
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Survival, containment
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Live microbial microcapsules
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Viruses
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Integrity, biosafety
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Encapsulated viral particles
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Microbiome
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Community balance
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Multi-species droplets
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APIs
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Solubility, delivery
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API-loaded microparticles
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Client Testimonials
"We evaluated several encapsulation strategies for single-cell studies, but only Creative Biolabs' microfluidic encapsulation platform consistently delivered true one-cell-per-droplet control while maintaining high post-encapsulation viability."
— Principal Investigator, Cell Engineering Program
"Protein aggregation and interfacial stress had been persistent challenges in our formulation work. The microfluidic protein encapsulation service helped us establish a far more reproducible and controllable process."
— Senior Scientist, Biopharmaceutical R&D
"As an academic user, we appreciated the flexibility of the service. The team adapted the encapsulation protocol to our limited material availability and provided clear technical guidance. The collaboration felt more like a joint development project than a standard service transaction."
— Postdoctoral Researcher, Translational Medicine Program
"The team helped us precisely control particle size distribution and encapsulation efficiency across multiple lipid compositions. What impressed us most was not just the chip design, but the systematic DOE-driven optimization and the high reproducibility across batches, which significantly de-risked our scale-up strategy."
— Principal Investigator, Academic Nanomedicine Lab
Published Data
Massive and efficient encapsulation of single cells using a microfluidic device
A facile and efficient encapsulation of single cells relying on the massive and controllable production of droplets and collagen–alginate microgels using a microfluidic device is presented. High monodispersity and geometric homogeneity of both droplet and microgel generation were experimentally demonstrated based on the well-investigated microfluidic fabricating procedure. The reliability of the microfluidic platform for controllable, high-throughput, and improved single-cell encapsulation in monodisperse droplets and microgels was also confirmed. A single-cell encapsulation rate of up to 33.6% was achieved based on the established microfluidic operation.
Fig.1 Microfluidic single-cell encapsulation in droplets and collagen-alginate microgels.1,2
