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Nanomedicine and nanoparticle drug formulations have made their way into the development of unique therapies in almost all treatment subjects, including vaccines, antimicrobials, immunotherapy, cancer therapy, biological agents, and genetic medicine. Nevertheless, the translation of nanoparticle drug delivery systems from academic research to clinical practice has been investigated slowly. Notably, these problems can be solved by microfluidic technologies.

As an experienced specialist in the microfluidic technology, Creative Biolabs has a strong capacity to design efficient microfluidic chips to prepare nanoparticles, including drug nanosuspensions, polymer nanoparticles, theragnostic nanoparticles, structured nanoparticles, etc. Our mature microfluidics not only produces nanoparticles in a reproducible, well-controlled, and high-throughput pattern but also generates 3D environments with the continuous flow to mimic the pathophysiologic process.

Microfluidics-based Nanomedicine

Nanomedicine is described as the medical application of nanotechnology. Nanoparticle drugs are an important component in nanomedicine. These molecules create a means of tailoring the pharmacokinetic analysis and biological distribution of active pharmaceutical ingredients. Considering that the size and quality of nanoparticles directly affect their performance in vivo, there is a need for potent methods reproducibly producing high-quality nanoparticles of defined biophysical properties. Microfluidic technologies can firmly control the local particle-formation context in a continuous flow manner. Process parameters optimized on single microfluidic mixer chips will be straightly transferred to multi-mixer chips holding identical channel geometries to improve volume throughput and manufacture. Hence, microfluidics brings about a pathway to the production of high-quality nanoparticles that have been translated successfully from bench to bedside.

Fig. 1 Microfluidic chip for nanomedicine synthesis.¹

Nanomedicine Development Service at Creative Biolabs

Fig. 2 Designs of microfluidic mixers for lipid nanoparticle development.¹

The application of nanoparticle drug delivery systems in disease therapy has been prevalently studied in many fields. At Creative Biolabs, we have developed available microfluidic chips that are microscale fluidic circuits employed to manipulate liquids at the nanoliter scale. There is a summary listing the use of several microfluidic designs for the formulation of lipid nanoparticles, liposomes, and polymer nanoparticles to encapsulate and transport small molecular payloads.

Moreover, the continuous nature of the microfluidic system is inherently scalable, permitting optimization at low volumes, which is a benefit for rare or costly materials, together with scale-up through process parallelization. Given the above-mentioned advantages, microfluidics is supposed to be the new exemplification for nanomedicine formulation and production. Here, our experts are skilled at synthesizing nanoparticulate drug delivery systems by microfluidic chips, including but not limited to:

The microfluidic method is a versatile technology in the generation of nano- or micro-sized drug delivery systems, analysis of compounds, and assessment of the produced nanoparticles. Today, we’d like to offer dedicated devices and custom services to display the function of microfluidics for combinatorial preparation of nanoparticles, and the optimization of characteristics that nanoparticles should regulate for targeted drug therapeutics. Our groups pay attention to the microfluidic mixing strategies for preparing on required nanoparticles and also introduce the on-chip applications of nanoparticulate drug delivery systems.

• Microfluidic mixing and devices
  • Mixing by microfluidics
  • Y- and T-shaped microfluidic devices
  • Hydrodynamic flow focusing (HFF) microfluidic systems for nanoparticle preparation
  • Confined impinging jets mixer
  • Multi-inlet vortex mixer
• Application of nanoparticulate drug delivery systems by microfluidics
  • On-chip interaction with cells
  • Organ-on-a-chip
  • Cancer-on-a-chip

Key-benefits

• One-stop, customized solutions for microfluidics-based nanomedicine development projects;
• Our platform offers a novel opportunity to manufacture miniature biomedical equipment for a variety of applications;
• Microsystem technology has smaller dimensions and lower cost owing to batch fabrication;
• Skillful technicians with extensive expertise in microfluidic chips and microfluidic-based nanomedicine.

In nanomedicine, nanoparticulate drug delivery systems hold enormous potential for the therapy of numerous diseases, especially different cancers. As a reliable and famous provider in the microfluidic market, Creative Biolabs makes use of robust properties of microfluidics and has proposed concrete microfluidic approaches associated with drug discovery for nanomedicine development. Our strategies focus on the microfluidic fabrication of nanomedicines using advanced chips and nanoprecipitation methods. If you’ like to know more about our microfluidic chips and one-stop custom services, please directly contact us or send us an e-mail with specific requests.

Reference

1. Bostanabad, Puliga, et al. " Microfluidic Manufacture of Lipid-Based Nanomedicines " Pharmaceutics 14.9 (2022): 1940.

For Research Use Only. Not For Clinical Use.