With professional team and advanced microfluidic platforms, Creative Biolabs offers a range of function-proven 3D tissue and organ-on-a-chip models to promote your research.
CBLMF™ blood-brain barrier model recreates the in vivo microenvironment by replicating a histological slice of brain tissue cells. The model is able to do this by communicating with endothelial cells across the blood-brain barrier (BBB). As a result, shear-induced endothelial cell tight junctions are easily achieved in the model using physiological fluid flow.
Features
• Accurate in vivo hemodynamic shear stress
• Real-time visualization and quantitation of cellular and barrier functionality
• Significant reduction in cost and time
• Robust and easy to use protocols
The CBLMF™ 3D inflammation model was developed to study the entire inflammation pathway in a dynamic environment. The platform delivers a physiologically realistic model (including flow and shear) and enables real-time tracking of rolling, adhesion, and migration processes. The model recreates a histological slice of co-cultured tissue and/or tumor cells with a lumen of endothelial cells. It has been successfully validated against in vivo studies showing excellent correlation with rolling velocities, adhesion patterns, and migratory processes.
The CBLMF™ 3D inflammation model provides a realistic testing environment including:
• Physiological shear stress within a microvascular environment
• In vivo like vascular morphology with fully enclosed lumen
• Co-culture capability for cell-cell interactions
• Quantitative real-time rolling, adhesion, and migration data from a single experiment
Examples of Models Functionalized in SynRAM Devices
CBLMF™ 3D Cancer Model is a 3D tissue model for real-time visualization and quantitative assessment of cell-cell and cell-drug interactions in a physiologically and morphologically realistic tumor microenvironment. The system enables (a) circulation in the microvasculature, (b) transport across the vessel walls, and (c) delivery to the tumors. Starting with scans of vascular networks incorporated with interstitial and tissue/tumor spaces, the model creates an in-vitro tumor microenvironment akin to a viable histological slice.
Features
• Side by side architecture enables quantitative real-time visualization
• Physiological leaky vasculature with engineered porous structures
• Morphologically realistic in vivo based architecture
• Physiologically realistic convective and diffusive transport
• Microfluidic platform with ultra-low consumable volumes
CBLMF™ Lung Model is a novel Air Liquid Interface model mimicking lung architecture. The microfluidic device is functionalized with epithelial cells surrounded by vasculature comprised of endothelial cells. The CBLMF™ Lung Model structure maintains an Air Liquid Interface across the airway cells. As a result, airway tubules form and transport mucus and are maintained by the surrounding epithelium. Cell morphology, airway structure, cell-cell interactions, and functions of the airway (e.g. mucus transport, ciliary beating, therapeutic-induced improvements) can be visualized and quantified in real-time in both normal and diseased conditions.
Features
• Morphologically realistic airway structure and environment
• Air Liquid Interface (ALI) across the epithelium and endothelium
• In-Vivo hemodynamic shear stress
• Real-time visualization of cellular and barrier functionality including mucus, ciliary beating, immune cell interactions, and therapeutic screening
• Robust and easy to use protocols
Examples of Models Developed Using CBLMFTM Lung Model Devices
CBLMFTM 3D toxicology model provides real-time optical monitoring, multi-compartment, multi-cellular architecture, and low reagent requirements.
Features
• Physiologically realistic morphological, fluidic and 3D cellular conditions
• Universal platform with architecture-specific of the desired organ
• Significant reduction in cost and time
• Robust and easy to use protocols
• Compatible with standard analytical instruments for both on-chip and off-chip assays including omic methodologies for systems biology and bioinformatic analysis
Q: What is the CBLMF™ 3D Tissue and Organ-On-A-Chip Model Development Service?
A: The CBLMF™ 3D Tissue and Organ-On-A-Chip Model Development Service offers advanced models that mimic human tissue and organ functions using microfluidic technology. These models provide realistic physiological environments, enabling more accurate drug testing and disease research.
Q: How do these models handle mechanical and chemical stimuli?
A: The models incorporate real-time control of shear stress, pressure, and chemical gradients, closely mimicking in vivo conditions. This capability is essential for studying cellular responses to various stimuli, which is critical for drug testing and disease modeling.
Q: Can these models be customized?
A: Yes, the models can be customized to meet specific research needs. Customization options include adjusting channel dimensions, materials, and the incorporation of various cell types to accurately replicate the desired organ or tissue environment.
Q: How do these models support high-throughput screening?
A: The microfluidic platforms enable parallel processing of multiple samples, significantly increasing throughput. This capability allows for the rapid testing of numerous drug candidates, facilitating high-throughput screening and accelerating drug discovery .
Q: What makes these models cost-effective?
A: By reducing the need for animal testing and providing more predictive data earlier in the drug development process, these models save time and resources. They streamline the research workflow, making the development of new therapies more efficient and less expensive.
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Creative Biolabs has established a comprehensive microfluidics technique platform.
