Microfluidic technology, which controls the behavior of minute fluid volumes within microscale channels, has emerged as an indispensable high-precision technology globally for advancing scientific research and optimizing industrial processes, thanks to its core advantages of precision and efficiency. Creative Biolabs’ flow continuous reaction chip development service lies at the heart of this technology. We specialize in manufacturing cutting-edge microfluidic chips tailored for continuous flow applications. As a key innovation in the microfluidic field, our service meets your stringent requirements with enhanced precision and efficiency.
Our service supports customization. Across various fields, we can craft a path that combines practical applications with conceptual innovation, transforming any of your ideas into valuable, functional tools.
Service Content
Chip Design
Our microfluidic experts design chips using advanced fluid dynamics principles, creating optimized microchannel geometries for diverse applications—from cell-based assays requiring gentle sample handling to chemical synthesis needing precise reaction control.
Our chip design solutions will specifically incorporate exclusive functional modules, with continuous optimization focused on microfluidic performance. Examples include integrating mixing elements for reagent homogenization, customizing channel dimensions to achieve specific residence times, and standardizing interfaces for detection systems.
Fabrication
To stably produce high-quality chips, we possess cutting-edge microfabrication technologies. We select the most suitable ones based on different application requirements, and also recommend the most cost-effective production technologies tailored to your production scale. Details of specific production technologies and their advantages are shown in the table below.
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Production Technologies
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Advantages
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Photolithography
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Enable sub-micron precision for critical applications
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Soft lithography
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Offer flexibility with biocompatible materials like PDMS
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Injection molding
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Ensure consistency for industrial-scale orders
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Every chip we produce undergoes rigorous inspection, with strict quality control implemented throughout all manufacturing processes.
Customization
We offer specialized customization services for microfluidic applications. Before initiating formal design and production, we conduct thorough communication with you to ensure the chips we develop meet all your experimental requirements or production objectives. Common customized design solutions and their application scenarios are as follows.
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Application Scenarios
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Description
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Specialized channel networks & material selection
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Chemical-resistant polymers for harsh reactions, biocompatible options for biomedicine
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Surface modifications
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Control fluid or biomolecule interactions
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In summary, our services extend beyond chip design and manufacturing to cover every aspect of the microfluidic workflow. From integrating real-time sensing capabilities to designing multi-step reaction pathways, we effectively safeguard the smooth and efficient progression of your production or experiments.
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Service Applications
Biomedical Research
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Applications
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Description
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High-throughput drug screening
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Precisely controlling reagent interactions, accelerating candidate evaluation, accelerating candidate evaluation
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Isolating and detecting trace biomarkers in biological samples
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Enhance diagnostic accuracy to support early disease detection
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Biocompatible designs
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Ensuring compatibility with cells and tissues, making them ideal for applications like organ-on-a-chip models and personalized medicine research
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Chemical Synthesis
Continuous flow chips excel in the synthesis of fine chemicals and pharmaceuticals, as these fields demand extremely high precision. The chips we produce enable real-time control of reaction conditions.
Environmental Monitoring
Our microfluidic chips can sensitively detect environmental pollutants in water, air, and soil. Their size can be designed to fit into portable monitoring systems, enabling the sensitive real-time detection of pollutants such as heavy metals and organic compounds.
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Technology Integration Capabilities
A key strength of our service is seamless integration with existing microfluidic ecosystems. We design chips compatible with common pumping systems, detection tools (fluorescence, electrochemical, and optical sensors), and data acquisition software—minimizing workflow disruptions.
For advanced applications, we integrate on-chip sensing for real-time reaction monitoring, enabling immediate parameter adjustments. This integration turns standalone chips into complete microfluidic workstations, enhancing process control and data quality.
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Client Testimonials
"Their team translated our vague microfluidic requirements into a functional chip seamlessly. The prototype worked as expected, and the communication throughout the process was prompt and clear."
— Mark Davis, R&D Manager at a Pharmaceutical Company
"We needed a chip resistant to harsh chemical reagents, and they delivered perfectly. It has improved our reaction efficiency without any leakage issues, which saved us lots of troubleshooting time."
— Sarah Johnson, Chemical Process Engineer
"The customization service is impressive. They adjusted the chip’s channel design twice based on our test data, showing great patience and professionalism. Our lab now relies on their products for daily experiments."
— Dr. Robert Chen, Biomedical Researcher
"Compared to other suppliers, their turnaround time is much faster. We received the final chips right on schedule, which helped us meet our project deadline. The quality is consistent with the prototype."
— Lisa Wilson, Production Supervisor in Fine Chemicals
"They provided useful technical advice on integrating the chip with our existing equipment. The after-sales support ensured a smooth transition, making the whole collaboration very reassuring."
— Michael Brown, Engineering Director
Published Data
Enantioselective reaction monitoring utilizing two-dimensional heart-cut liquid chromatography on an integrated microfluidic chip
The report described development of the first two-dimensional HPLC-chip was realized by the integration of two different columns packed with reversed-phase and chiral stationary phase material on a microfluidic glass chip, coupled to mass spectrometry. Directed steering of the micro-flows at the joining transfer cross enabled a heart-cut operation mode to transfer the chiral compound of interest from the first to the second chromatographic dimension. This allows for an interference-free determination of the enantiomeric excess by seamless hyphenation to electrospray mass spectrometry.
Fig.1 Schematic drawing of the instrumental setup and operation principal for heart-cut 2D chip LC/MS.1,2
References
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Carsten Lotter, Elisabeth Poehler, Josef J. Heiland, Laura Mauritza, Detlev Belder "Enantioselective reaction monitoring utilizing two-dimensional heart-cut liquid chromatography on an integrated microfluidic chip" Lab Chip, 2016,16, 4648-4652. https://doi.org/10.1039/C6LC01138A
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Distributed under Open Access license CC BY 3.0, without modification.
Created December 2025
