Custom Microfluidic Manufacturing Services

Creative Biolabs provides a full range of state-of-the-art organ-on-chip services, crafted to help you launch and advance your research projects smoothly. We've focused exclusively on organ-on-chip research, development, and applications. Our diverse products are now used by pharmaceutical companies worldwide.

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Fig. 1 Simplified microfluidic system. (Wei, et al., 2005)

Custom microfluidic fabrication services refer to professional solutions for designing and manufacturing tailored microfluidic devices—such as chips with precise microchannels—using materials like PDMS, glass, or polymers, to meet specific fluid-handling needs in fields like biomedicine and chemical analysis. Beyond delivering custom designs that meet precise fluid dynamics criteria, our solutions ensure material compatibility with biological/chemical environments while balancing precision and cost efficiency throughout the process from prototyping to mass production.

A chip with precise microchannels using PDMS. (OA Literature) Fig. 1 A three-layer structure comprising a fluidic, flexible PDMS membrane and control layers.1,3

Service Portfolio

Our design process begins with taking your specific needs and turning them into working microfluidic designs. We tailor solutions to your specific needs, whether you require cell sorting chips with precise laminar flow control or diagnostic devices with integrated fluid delivery systems.

Material Science Expertise

Selecting the right material is critical to performance. Our portfolio includes:

Material Applicable Occasion
PDMS For biological applications requiring flexibility and gas permeability
Glass When optical transparency and chemical resistance are paramount
PMMA Cost-effective solutions with excellent mechanical properties
Specialty polymers For high-temperature or corrosive environments

Our processing capabilities, ranging from injection molding to anodic bonding, ensure that your material selection translates into reliable, production-ready components.

Scalable Production

Make the seamless move from prototype to volume production with our scalable manufacturing solutions. We also provide specialized quality control protocols, which we strictly adhere to during production. This ensures every unit meets final standards for both dimensions and functionality, so you won't have to worry about variations between production batches.

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Service Workflow

We begin by getting a clear understanding of your application goals, performance requirements and constraints. Our technical specialists work with your team to define success criteria, from fluid volume parameters to regulatory compliance needs.

Engineering & Simulation Before physical manufacturing begins, our designers will create a 3D model for your custom solution. By running simulations on the model, we identify potential issues, resolve them, and optimize design performance, thus eliminating unnecessary waste.
Prototype Development We ensure functional prototypes are built using materials and processes consistent with their final application, and subject them to rigorous testing to guarantee error-free production of the final product.
Iterative Refinement We refine designs to boost performance based on test results. This collaborative process keeps going until your prototype meets all specifications.
Prototype Development For volume orders, we scale production while maintaining strict quality control. Every batch includes validation testing to ensure consistency with your approved prototype.

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Applications Across Industries

Biomedical & Diagnostics

  • Point-of-care testing devices for rapid disease detection
  • Cell culture chips with controlled microenvironments
  • Automated liquid handling systems for laboratory workflows

Environmental & Chemical Analysis

  • Portable sensors for monitoring water and air quality
  • Microreactors for precise chemical synthesis
  • Sample preparation systems for detecting trace analytes

User-Friendly Interface

  • Micro-dispensing systems for electronics assembly
  • Quality control sensors for food and pharmaceutical production
  • Fuel cell components with optimized fluid distribution

Client Testimonials

"Their custom microfluidic fabrication service met our lab's requirements well. The team clarified technical details upfront, used the biocompatible material we specified, and the final devices had no issues."

— Sarah L., Research Director

"We worked with them for custom microfluidic chips, and the process was straightforward. They adjusted the channel design to fit our sample volume needs, delivered on time, and the chips performed reliably in our initial flow tests."

— Michael T., Process Engineer, Pharmaceutical Manufacturer

"We needed a tailored microfluidic system for cell sorting, and they delivered. The fabrication quality was consistent, they addressed a minor design tweak quickly, and the device integrated smoothly with our existing equipment."

— Dr. Elena M., Biomedical Researcher

"We provided our microfluidic specs, they double-checked key dimensions, and the finished chips matched our requirements. Post-delivery support was also responsive."

— James K., MedTech Entrepreneur

"For our diagnostic tool project, their custom microfluidic fabrication worked well. They balanced precision with turnaround time, the flow control in the devices was accurate, and they kept us updated throughout the process."

— Dr. Rajiv P., Chemical Engineer

Published Data

Lung adenocarcinoma cells selection by cavity-added serpentine microchannels

A novel microfluidic device specifically designed for isolating human lung cancer cells in microchannels utilizes magnetic nanoparticles to enable target A549 cells immobilized on magnetic beads to be manipulated and captured in cavities by an external magnetic field, exhibiting excellent cell separation performance. This system combines magnetic beads with target cells through selective binding via aptamers.

A cavity-added serpentine microchannels. (OA Literature) Fig. 2 Schematic of the proposed SMAC microfluidic device, including a glass substrate, a polydimethylsiloxane (PDMS) channel and an external magnet for capturing A549 cells.2,3

Red blood cell deformability assessment in continuous flow with microfluidic devices

A study presented a novel integrative microfluidic device able to perform continuous separation of a desired amount of blood cells, without clogging or jamming, and at the same time, capable to assess the deformation index (DI) of both WBCs and RBCs. The microfluidic device used in a study was designed to include a cross-flow filtration barrier and several sequences of hyperbolic channels in the outlet of the sub-channels.

Blood cells flowing through cross-flow filtration barrier.(OA Literature) Fig. 3 Blood cells flowing through cross-flow filtration barrier to the direction of the outlets and hyperbolic chamber.2,3

References

  1. Scott, S.M., Ali, Z., et al. Fabrication Methods for Microfluidic Devices: An Overview. Micromachines 2021, 12, 319. https://doi.org/10.3390/mi12030319
  2. Mingzhu Xie, et al. Functional microfluidics: theory, microfabrication, and applications. Int. J. Extrem. Manuf. 2024,6 032005. https://doi.org/10.1088/2631-7990/ad2c5f
  3. Distributed under Open Access license CC BY 4.0, without modification.

Created August 2025

FAQs

Q: What factors influence project cost?
A: Project pricing depends primarily on design complexity, material selection, and production volume. Prototype costs mainly cover engineering work, while mass production brings cost reductions. We'll provide you with a detailed cost estimate for your specific case before the project starts.
Q: What is typical delivery time?
A: This depends largely on your design and order volume. Generally, the larger the order size, the longer the delivery time will be. Once the final design is confirmed, we'll promptly provide you with a detailed breakdown of the delivery timeline.
Q: Do you ensure material compatibility with biological samples, like cell cultures?
A: Absolutely. Our PDMS undergoes surface treatment to prevent sample adhesion, and we test compatibility with common biological media. We'll share certification for your specific use case.
Q: Can you scale production from 10 prototype chips to 500 units? What's the cost difference per unit at scale?
A: Yes, we scale seamlessly. We possess specialized technologies to reduce costs in scaled-up production. Once you confirm the final design, we will provide you with a more detailed quotation, and we are confident that the result will be satisfactory to both parties.
Q: Can you adjust microfluidic designs if our research needs change mid-project?
A: Yes, we can modify designs based on updated needs. We'll review the changes with you first to align with your goals, then adjust fabrication steps without unnecessary delays.
Q: Do you provide support for testing the custom microfluidic chips after delivery?
A: Absolutely. We offer basic guidance on testing protocols and can answer questions about device operation. If issues arise, we'll help troubleshoot to ensure they work as intended.

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Ready to Transform Your Microfluidic Project? Get a Quote Now

We deliver precise, reliable custom fabrication services to support your work—whether you're developing breakthrough diagnostic tools, optimizing industrial processes, or advancing scientific research.

Contact us for a quick consultation to discover how we can speed up your journey from concept to commercialization.

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