Particles Synthesis

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Creative Biolabs is a world-leading services provider in the field of microfluidic chip development. Based on the microfluidics that emerged as promising tools for the synthesis of particles, we are dedicated to supporting particle synthesis by designing and developing a high-quality and high-sensitivity microfluidic chip system to meet all of your requirements.

Introduction of Particle Synthesis

Particles are considered critical in versatile emerging frontiers, such as advanced drug delivery systems, biomolecular sensing, cancer theragnostic, molecular catalysis, and targeted imaging. In each of these fields, the properties of particles such as size, shape, composition, and surface chemistry can be systematically exploited to optimize their efficacy. All these cases require to have efficient, controllable, and reproducible techniques for particle synthesis and preparation.

Over the years, a variety of synthetic methods have been developed for producing particles. However, these conventional synthesis methods always tend to suffer from a lack of precise control of the mixing, nucleation, and growth processes. Therefore, a more general platform is required to increase the rate at which new particles can be synthesized and tested as potential applications become apparent.

Synthesis of particulate materials (a) in a batch reactor and (b) in a flow-based, microfluidic reactor. Fig.1 Synthesis of particulate materials (a) in a batch reactor and (b) in a flow-based, microfluidic reactor. (Park, 2010)

Microfluidic Chip Development for Particles Synthesis

The synthesis of particles has long been the focus of very intensive research because, from painting formulation to drug delivery, they cover a wide range of applications. With the intelligent design and construction of microreactors, recent studies employed microfluidics for controllable synthesis and application of particles with desired and predetermined structures. These functional particles produced in a well-controlled, reproducible, and high-throughput manner demonstrate superior performance in many fields. In addition, microfluidic technologies acting as a robust platform for the screening of particles offer a great route to accelerate the clinical translation of these functional materials.

Microfluidics has become one of the best options to create an effective mixing environment for particle preparation. Various particles can be synthesized using microfluidic techniques, including but not limited to:

For the synthesis process of particles, two distinct categories of microfluidic devices have been identified: microchannel-based and capillary-based microsystems.

  • Microchannel-Based Devices
  • a) Terrace-Like Microchannel Devices
    b) T-Junction Microchannel Devices
    c) Flow Focusing Microchannel Devices

  • Capillary-Based Devices
  • a) Cross-Flow Capillary Devices
    b) Co-Flow Capillary Devices
    c) Flow Focusing Capillary Devices

Microfluidic systems for magnetic particle synthesis. Fig.2 Microfluidic systems for magnetic particle synthesis. (Hao, 2018)

Advantages of Microfluidic Chips for Particle Synthesis

Microfluidics-based flow synthesis offers a variety of benefits over conventional batch synthesis, such as:

Our Microfluidic Services

With the rapid development of microfluidic manipulation methods, new particle synthesis strategies with better control and design of particle properties are expected to expedite in the coming years. As a leading service company, Creative Biolabs has extensive experience in microfluidic technology, aiming to offer the best and convenient microfluidic-related services for our global customers. Our seasoned scientific team has developed an integrated microfluidic-based particle synthesis platform to meet all of your specific requirements. If you are interested in learning more about our solutions, please do not hesitate to contact us.

References

  1. Park, J. I.; et al. Microfluidic synthesis of polymer and inorganic particulate materials. Annual Review of Materials Research. 2010, 40, 415-443.
  2. Hao, N.; et al. Microfluidic synthesis of functional inorganic micro-/nanoparticles and applications in biomedical engineering. International Materials Reviews. 2018, 63(8), 461-487.

For Research Use Only. Not For Clinical Use.

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