Microfluidic Chip Development for Organ-On-A-Chip

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The currently used 2D monolayer cells cannot accurately reflect the structure, function, and mechanical characteristics of living tissue, nor can they reproduce the highly complex and dynamic 3D environment in the body. The organo-on-a-chip based on microfluidic technology can simulate the complex structure, microenvironment and physiological functions of human organs, so it has gradually become an ideal tool for new drug screening and toxicity evaluation. Creative Biolabs can provide customers with high-quality organ-on-a-chip design and customization services relying on its profound technical precipitation.

Organ-On-A-Chip and Its Advantages

Microfluidic Chip Development for Organ-On-A-Chip

Since the current cell or animal models for testing the efficacy of drugs cannot predict the response of human organs to drugs well, some countries or regions prohibit animal experiments, cost issues, etc., development of good drug efficacy prediction and evaluation tools has become an urgent need to solve. Organ-on-a-chip is an application based on microfluidic technology. Using micromachining technology, scientists can create a bionic system on the microfluidic chip that can simulate the main functions of human organs. Organ-on-a-chip not only has the characteristics of miniaturization, integration and low consumption of microfluidic technology, but also can accurately control multiple system parameters such as chemical concentration gradient and fluid shear force, and can also build cell graphics culture and realize the tissue-tissue and organ-organ interface interaction, so as to truly simulate the complex structure, microenvironment and physiological functions of human organs.

At present, researchers have realized the construction of many human organs on the microfluidic chip, including chip liver, chip lung, chip intestine, chip blood vessel, chip heart and multi-organ chips. Some of them have entered the practical stage, for example, a chip kidney has been used for drug screening, and a chip liver has also been used to test the liver toxicity of drugs.

Solutions from Creative Biolabs

Microfluidic Chip Development for Organ-On-A-Chip

Creative Biolabs has a professional microfluidic technology team that has helped customers successfully design and build multiple organ chips. Taking the construction of an artificial lung on a microfluidic chip as an example, on lung-on-a-chip, the lung simulation microcavity is composed of two parallel microchannels and two hollow lateral cavities on both sides. The central microchannels are separated by a porous and flexible extracellular matrix (ECM) modified PDMS membrane. The PDMS membrane acts as a scaffold, with human alveolar epithelial cells cultured on the top and pulmonary microvascular endothelial cells cultured on the bottom. This design enables air to form an air-liquid interface after entering the upper epithelial chamber. The hollow microchannels on both sides of the flexible membrane are vacuum chambers, which can simulate physiological respiration movement through the mechanical stretching of the PDMS membrane driven by pressure. The separated channel structure makes it possible to precisely control the flow of liquid and deliver immune cells and nutrients to epithelial and endothelial cells, respectively. This breathing chip system can be used to study lung inflammation/infection responses at the organ level and explore lung nanotoxicity.

The high-level microfluidic technology team and many years of development experience in the field of organ-on-a-chip make Creative Biolabs the leading organ chip expert in the industry. We can provide customers with professional and high-quality organ-on-a-chip design and customization services based on microfluidic technology. If additional help is needed, please directly contact us and consult our technical supports for more details.

For Research Use Only. Not For Clinical Use.

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