What types of double emulsions can you generate using microfluidics?

We specialize in producing highly uniform W/O/W (water-in-oil-in-water) and O/W/O (oil-in-water-in-oil) emulsions. Both types can be tailored for different payloads, such as proteins, peptides, nucleic acids, nanoparticles, probiotics, or active cosmetic ingredients.

Can you help customize the emulsion size and shell thickness?

Yes. We can fine-tune flow rates, chip geometry, and surfactant systems to control droplet diameter (from a few microns to hundreds of microns) and shell thickness, meeting your specific formulation needs.

What information do you need from clients before starting a project?

We usually request payload type, desired emulsion configuration, preferred solvents/surfactants, stability requirements, and intended application. With this, we can design a customized project plan.

Are your services suitable for both research and industrial projects?

Yes. We support early-stage academic research, proof-of-concept studies, and pilot-scale projects. Our team can also provide process transfer guidance for clients moving toward industrial production.

Can your double emulsions be designed to release ingredients only under specific environmental conditions, like certain pH levels?

Yes. We can engineer the emulsion's middle phase to respond to stimuli like pH, enabling targeted release of active ingredients under your desired conditions.

What is the typical turnaround time for a project?

Turnaround varies with complexity, but most projects are completed within 2–6 weeks, including consultation, synthesis, testing, and reporting. Expedited services may be available.

How do I initiate a project with Creative Biolabs?

Simply contact us through our online inquiry form or email. Our specialists will schedule a consultation, draft a project proposal, and guide you through sample submission and study initiation.

Microfluidics-based Multiple Emulsion Synthesis Services

Creative Biolabs offers advanced microfluidics-based multiple emulsion synthesis services, utilizing precisely controllable microfluidic chip structures to achieve efficient synthesis of multiple emulsions ranging from W/O/W and O/W/O to more complex structures. Our platform enables precise regulation of droplet size, interfacial stability, and component distribution at the nanometer to micrometer scale.

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Fig. 1 Simplified microfluidic system. (Wei, et al., 2005)

Compared to traditional mechanical emulsification methods, microfluidic technology enables precise control over droplet size, layer count, interfacial thickness, and distribution uniformity, thereby ensuring batch-to-batch consistency and high reproducibility of the emulsion.

Creative Biolabs utilizes microfluidic platforms to precisely construct multiphase emulsion systems at scales ranging from submicron to micrometers. These multiphase emulsions find extensive applications in cutting-edge fields such as controlled drug release and delivery, protection and encapsulation of active substances, development of nutritional and functional foods, and cosmetic and skincare formulations.

Our Service Portfolio

Our microfluidics-based multiple emulsion synthesis services cover a comprehensive portfolio designed to support diverse research and industrial applications. By integrating state-of-the-art microfluidic chip architectures and precise process control, we offer tailored solutions that span from fundamental research to scale-up validation.

Customized Multiple Emulsion Design

W/O/W, O/W/O, and complex hierarchical structures
Tunable droplet size (from sub-micrometer to hundreds of micrometers)
Adjustable shell thickness and multilayer composition
Selection of biocompatible oils, aqueous phases, and surfactants

High-Precision Emulsion Fabrication

Single- or multi-channel microfluidic systems
Flow-focusing, T-junction, and co-axial geometries
Continuous and scalable production modes
Batch-to-batch reproducibility with CV < 5%

Functional Encapsulation & Loading

Encapsulation of small molecules, peptides, proteins, nanoparticles, dyes
Multi-agent co-encapsulation strategies
Controlled release systems for drug delivery and nutraceuticals
Payload protection against degradation or leakage

Analytical & Characterization Support

Particle size distribution and polydispersity index (PDI) reports
Morphological analysis with microscopy imaging
Stability and leakage rate testing under various conditions
Encapsulation efficiency and release kinetics evaluation

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Our Competitive Advantages

What sets our services apart is our combination of scientific expertise, flexibility, and industry compliance.

Cross-Industry Experience

We have served many clients across cosmetics, pharmaceuticals, and agriculture, ensuring solutions tailored to your sector's unique regulatory demands.

Cost-Efficiency Without Compromise

We source raw materials directly from certified suppliers and optimize processes to minimize waste, ensuring your project stays within budget while meeting performance standards.

Cutting-Edge R&D Capabilities

Our in-house laboratory is equipped with membrane emulsification technology. We also collaborate with top universities to integrate the latest research on biopolymer stabilizers into our available technologies.

Our Streamlined Service Process

We follow a streamlined and transparent workflow to ensure that every microfluidics-based multiple emulsion synthesis project is delivered with precision, reproducibility, and scalability.

Service Process	Description
Needs Assessment	When you reach out to us for consultation, our expert team will conduct a feasibility study as soon as possible based on your requirements.
Chip & Process Configuration	Selection of suitable microfluidic chip geometry (flow-focusing, T-junction, co-axial, or hybrid). Optimization of fluid dynamics parameters (flow rates, viscosities, interfacial tensions). Material compatibility checks for aqueous, oil, and surfactant systems.
Emulsion Synthesis & Encapsulation	Controlled fabrication of multiple emulsions under optimized conditions. Encapsulation of single or multiple payloads and adjustment of multilayer stability and release properties.
Production & Delivery	We then move into full-scale production, which is carried out in strict compliance with the quality management standards specified for our production facilities.

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Real-World Applications

Our emulsions solve critical challenges across sectors:

Cosmetics: Encapsulate labile active ingredients to reduce their exposure to air and light, extending product shelf life. They also enable "sustained release" to minimize the irritation of active ingredients on the skin.
Food: Encapsulate oxidation-prone and odorous functional ingredients to mask unpleasant odors, protect activity, and achieve controlled release simultaneously.
Pharmaceuticals: Produce drug carriers to realize targeted delivery, controlled release, and reduction of toxic side effects.
Agriculture: Produce slow-release pesticide formulations to reduce pesticide volatilization and loss, extend efficacy, and lower pollution to soil and water sources.

Client Testimonials

"Our project required stable W/O/W emulsions to co-encapsulate a peptide drug and a hydrophobic adjuvant. Creative Biolabs delivered emulsions with remarkably uniform size distribution and over 90% encapsulation efficiency. Their microfluidics expertise saved us months of development time."

— Sarah Chen, R&D Director

"With Creative Biolabs' microfluidic multiple emulsion synthesis, we achieved reproducible encapsulation and significantly improved survival rates under simulated GI conditions. This opened the door to our functional food line."

— Dr. Michael Lee, Chief Scientist

"We were looking for a template system to create hollow polymer microspheres. Creative Biolabs produced highly uniform multiple emulsions that acted as perfect precursors for our materials."

— Lisa Miller, R&D Manager

"As a small food startup, we needed a cost-effective W/O emulsion for our nut butter. They helped optimize the process to cut production costs slightly. Reliable service overall."

— Jake Torres, Founder of a food company

"We approached them for a single emulsion to encapsulate a plant extract. Their technical team explained the pros and cons of different emulsifiers clearly, and the end product had good encapsulation efficiency as tested."

— Dr. Elena Carter, Product Development Lead

"There was a minor delay in the prototype delivery, but their team communicated proactively and compensated by speeding up the subsequent testing phase. The final emulsion performed well in our application."

— Mark Wilson, Quality Control Director

Published Data

One-step production of multiple emulsions

Multiple emulsions have great potential for application in food science as a means to reduce fat content or for controlled encapsulation and release of actives. Typically, multiple emulsions are prepared via two emulsification steps and a variety of approaches have been deployed to give long-term stability. Recently, several contrasting methods have been demonstrated which give rise to stable multiple emulsions via one-step production processes.

Fig. 1 Schematics showing the two-step production of a multiple emulsion.^1,2

References

Clegg, Paul S., Joe W. Tavacoli, and Pete J. Wilde. "One-step production of multiple emulsions: microfluidic, polymer-stabilized and particle-stabilized approaches." Soft Matter 12.4 (2016): 998-1008. https://doi.org/10.1039/C5SM01663K
Distributed under Open Access license CC BY 3.0, without modification.

Created September 2025

FAQs

Q: What types of multiple emulsions can you produce?

A: We specialize in W/O/W and O/W/O emulsions, as well as more complex hierarchical structures. Our microfluidic systems allow precise control over droplet size, shell thickness, and composition, ensuring high reproducibility across batches.

Q: Can you encapsulate both hydrophilic and hydrophobic compounds simultaneously?

A: Yes. One of the key advantages of multiple emulsions is their ability to load diverse payloads in separate compartments. For example, we can co-encapsulate peptides in the inner phase and lipophilic molecules in the outer phase.

Q: How do you handle sensitive biomolecules such as proteins or probiotics?

A: We carefully design encapsulation protocols to minimize shear stress and exposure to harsh solvents. This helps preserve the activity and viability of labile compounds, including enzymes, probiotics, and therapeutic proteins.

Q: What information do I need to provide before starting a project?

A: We typically require details about the target application, desired emulsion type, payload characteristics, target size range, and stability requirements. Based on this, we propose a customized workflow and project plan.

Q: How long does a typical project take from consultation to delivery?

A: Timelines vary depending on complexity. This includes consultation, method optimization, synthesis, characterization, and delivery of emulsions or final reports. Expedited timelines are available upon request.

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By combining precision engineering with flexible customization, our services provide clients with reliable, reproducible, and scalable solutions tailored to their unique challenges. Our team is ready to help turn ideas into tangible results.