Background What We Can Offer? Workflow Why Choose Us? Published Data FAQs Featured Services Feature Products
Accelerate Your Research and Development!
Microfluidic chips are revolutionizing cellular research by enabling precise control over the cellular microenvironment. Accelerate Your Cellular Research with Precision Microfluidics. Are you currently facing long drug development cycles, difficulty in high-throughput cell culture, challenges in real-time monitoring of cell growth, and high reagent costs? Creative Biolabs' Cell Growth Microfluidic Chip Development Service helps you accelerate cellular research, obtain real-time quantitative data, and reduce experimental costs through advanced micro-scale engineering and high-resolution imaging platforms.
Contact our team to get an inquiry now!
Background
Microfluidics provides an advanced platform for cell culture and analysis, overcoming the limitations of conventional methods. By creating miniaturized environments, microfluidic chips offer precise spatiotemporal control over a cell's surroundings, including nutrient delivery and mechanical stimuli. This is essential for emulating complex in vivo physiological conditions, leading to more biologically relevant and reproducible results. Microfluidic chips also enable real-time, continuous observation and are versatile for integrating various analytical techniques, from individual cell genomics to protein analysis. This makes them a powerful tool for quantitative studies of cell proliferation, migration, and drug response.
Microfluidic Chips for Drug Activity Evaluation
Our microfluidic chips offer a superior platform for evaluating drug activity, especially for cancer research using 3D tumor spheroids. Unlike 2D models, our systems create a controlled 3D microenvironment that more accurately mimics in vivo tumor growth. By precisely introducing drugs at varying concentrations, we enable long-term, real-time observation of cell growth inhibition without terminating the culture. This non-destructive approach provides critical insights into drug efficacy that traditional viability assays cannot offer.
Cell Growth Evaluation for mAb Production
Optimizing cell growth is critical for producing high-quantity therapeutic antibodies. Our microfluidic chips provide a novel platform with continuous, controlled conditions, ensuring a steady supply of oxygen and nutrients. Our service helps you optimize factors like cell adhesion molecules, microchannel geometry, and flow rate. This precise control ensures robust cell attachment and optimal growth, which is essential for maximizing recombinant protein yield and quality.
Fig.1 Microfluidic suspension cell growth.1,3
Applications
The precise control and high-throughput capabilities of microfluidic chips make them suitable for a diverse range of applications in both research and clinical settings.
Drug Discovery and Screening
High-throughput screening of drug candidates on cellular models in a physiologically relevant microenvironment.
Organ-on-a-Chip Models
Creation of miniature organs that mimic human physiology, enabling more accurate disease modeling and drug toxicity testing.
Individual Cell Analysis and Genomics
Isolation and analysis of individual cells for advanced studies in genomics, proteomics, and metabolomics.
Stem Cell Research
Controlled culture and directed differentiation of stem cells for regenerative medicine and developmental biology.
Cancer Research
Studying tumor cell migration, metastasis, and response to therapeutic agents in a controlled microenvironment.
Pathogen and Infection Research
Monitoring bacterial and viral growth dynamics and testing antibiotic or antiviral susceptibility.
What We Can Offer
Creative Biolabs is your partner for microfluidic innovation. We offer a range of products and services designed to meet your specific research and development needs.
We design and fabricate bespoke microfluidic chips tailored to your unique application, from simple cell culture arrays to complex multi-channel systems.
We provide professional fabrication services for researchers with their own designs, ensuring high-quality, reliable chip production.
Our comprehensive service covers everything from initial design and simulation to final validation and data analysis, providing a complete solution from start to finish.
We provide a selection of pre-designed microfluidic chips for common applications, offering a faster and more cost-effective solution for standard cellular assays.
Cellular Assay Integration
We assist in integrating and optimizing your specific cellular assays onto the microfluidic platform, ensuring seamless transition and high performance.
Leverage our specialized benefits—Request a quotation today
Workflow
Why Choose Us?
Creative Biolabs' commitment to precision, innovation, and customer-centric service sets us apart in the microfluidics landscape. Our team of seasoned scientists and engineers brings a depth of knowledge that ensures the success of even the most complex projects. We are dedicated to providing a seamless experience and delivering high-quality, reproducible results that accelerate your research.
Advantages:
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Precision and Reproducibility: Our microfluidic chips offer unparalleled control over the cellular microenvironment, ensuring highly reproducible results.
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High-Throughput and Automation: Our designs are optimized for high-throughput screening, allowing you to process more samples with less time and effort.
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Low Reagent Consumption: The micro-scale nature of our chips drastically reduces the amount of expensive reagents and cell culture media required, significantly lowering your operational costs.
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Real-Time Data Collection: The transparent materials and integrated designs of our chips facilitate real-time, non-invasive observation and data collection, giving you dynamic insights into cellular behavior.
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Mimicking In vivo Conditions: We specialize in designing chips that replicate complex biological conditions, such as nutrient gradients and mechanical stimuli, leading to more physiologically relevant data.
Published Data
Fig.2 A microsystem for the cultivation of hepatocytes and for the detection of secreted growth factors.2,3,
Microfluidic technology has been validated in numerous studies for its ability to create more physiologically relevant models for drug testing. For example, a published study explored the use of a microfluidic platform to form and cultivate 3D tumor spheroids for the evaluation of anticancer drug activity. The experiment involved introducing drugs at varying concentrations and frequencies into the micro-system. The results demonstrated that this approach allowed for long-term, real-time observation of cell growth inhibition without the need for destructive viability assays, providing a significant advantage over traditional 2D culture methods. The study's findings underscored the microfluidic platform's potential to provide more accurate predictions of drug efficacy and to offer crucial insights into the kinetics of drug response, which are essential for advancing cancer research and drug development.
FAQs
Q: What are the key advantages of microfluidic chips over conventional cell culture platforms?
A: Microfluidic platforms offer superior spatiotemporal control, enabling more dynamic and physiologically relevant cell culture environments. They facilitate real-time, non-invasive imaging, drastically reduce reagent consumption, and can be customized to closely mimic in vivo conditions, leading to more accurate and reproducible experimental outcomes.
Q: Are microfluidic chips compatible with various cell lines and established protocols?
A: These platforms are highly adaptable. Custom chip designs are developed to be compatible with a wide range of cell types, growth media, and existing protocols, ensuring seamless integration into your research workflow and maximizing the value of your established methodologies.
Q: How does microfluidic chip material selection impact cell culture?
A: The choice of material, such as PDMS, glass, or thermoplastics, is critical. Materials must be biocompatible to ensure cell viability and prevent nonspecific binding. They also influence surface properties, optical transparency for imaging, and gas permeability, all of which are tailored to the specific cellular assay.
Q: Can these microfluidic systems support long-term, dynamic cellular studies?
A: Yes, microfluidic platforms excel at long-term studies. By continuously perfusing fresh media, they can maintain a stable and controlled environment for days or weeks. This allows for real-time monitoring of slow processes like stem cell differentiation, drug resistance development, or long-term cellular interactions, providing kinetic data not possible with static cultures.
Q: How are different cell culture models, like 2D vs. 3D, handled on a microfluidic chip?
A: Microfluidic chips are highly versatile for various culture models. They can support traditional 2D monolayer cultures with precise flow control, as well as complex 3D models like spheroids or organoids. The chips' microchannel geometries can be designed to facilitate the formation and maintenance of 3D structures, providing a more physiologically relevant environment for research.
Creative Biolabs is your trusted partner for custom microfluidic solutions, committed to accelerating your research with precision and expertise. Our Evaluate Cell Growth Microfluidic Chip Development Service is designed to provide you with the tools you need to achieve groundbreaking results.
Featured Services
Feature Products
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CAT No
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Material
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Product Name
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Application
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MFCH-001
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Glass
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Herringbone Microfluidic Chip
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Processing samples and reagents in nucleic acid analysis, blood analysis, immunoassays and point-of-care diagnostics.
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MFMM-0723-JS12
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Glass
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Double Emulsion Droplet Chip
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Our double emulsion microfluidic chip, incorporating localized modifications and a classic flow-focusing structure, is specifically designed to generate stable and uniform double emulsion droplets.
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MFCH-005
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PDMS
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3D Cell Culture Chip-Neuron
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Neuron cell culture and study of axon transport, axon protein synthesis, axon damage/regeneration, signal transduction of axon to somatic signal.
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MFCH-009
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PDMS
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Synvivo-Idealized Co-Culture Network Chips (IMN2 radial)
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SynBBB 3D Blood Brain Barrier Model/SynRAM 3D Inflammation Model/SynTumor 3D Cancer Model/SynTox 3D Toxicology Model
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MFMM1-GJS4
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COC
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BE-Doubleflow Standard
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Studying circulating particles, cell interactions and simple organ on chip system construction.
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MFMM1-GJS6
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COC
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BE-Transflow Custom
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Used to construct cell interface or Air-Liquid interface (ALI) to study more complex culture systems.
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Click here to explore our complete product catalog.
For detailed inquiries regarding our offerings, reach out to our specialists.
References
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Schmitz, Stute, et al. " Reliable cell retention of mammalian suspension cells in microfluidic cultivation chambers." Scientific Reports. 13 (2023): 3857. https://doi.org/10.1038/s41598-023-30297-5
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Son, Kyung Jin et al. "Detecting cell-secreted growth factors in microfluidic devices using bead-based biosensors." Microsystems & nanoengineering vol. 3 (2017): 17025. https://doi.org/10.1038/micronano.2017.25
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Distributed under Open Access license CC BY 4.0, without modification.
