Cell Culture

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With the advent of microfluidic technology, methods of cell culture are meeting a technological revolution. A variety of unique advantages of microfluidic chips provides cell culture more possibilities. As a professional microfluidic chip development services provider, Creative Biolabs also keeps our eyes on microfluidic chip-based cell culture. With an advanced technology platform and rich experience, we are confident in providing high-quality microfluidic chip development services for cell culture.

Microfluidics Chip and Cell Culture

There is an immediate need to develop reliable tissue models for pre-clinical research. It costs $2.5 billion and 10-15 years on average to bring a drug to market. To decrease drug development costs, it is critical to improving pre-clinical screenings' predictive power for excluding ineffective/toxic candidates as early as possible. Currently, the typical workflow in pre-clinical tests is to screen drug candidates on statically cultured cells followed by animal (e.g., rodent) experiments. However, both models have inherent limitations. In this context, microfluidic technologies-based cell culture is born as a new platform in a more physiologically relevant manner. Microfluidics is devices with mm-scale fluidic channels for controlled flow in small volumes (mL). These cell-laden microfluidic devices are often referred to as organs-on-a-chip. This technology can overcome the limitations of both static cell cultures and animal studies.

Advantages of Microfluidics-based Cell Culture Platform
  • The inherent continuous flow in microfluidic devices enables continuous nutrient/oxygen supply and waste removal to maintain a stable growth environment for cells therein.
  • Flow manipulation can apply desired gradients to the cells, which is especially useful for dosing studies.
  • The laminar flow in microfluidic channels can mimic blood physics in capillaries shear stress can be introduced, and multiple cell types can be connected for inter-tissue modeling.
  • Human cells are commonly used to obviate the inter-species discrepancy of animal models.
  • With precise engineering, studying a single factor is more feasible with organs-on-a-chip than with animals.

Application of Microfluidic Chip in Cell Culture

Overview of the microfluidic methods for single cell isolation and culture. Fig.1 Overview of the microfluidic methods for single cell isolation and culture. (Garcia Alonso, 2019)

Services at Creative Biolabs

With years of experience focusing on the field of microfluidic chip development, Creative Biolabs has accumulated extensive experience from step-by-step practice. During this long period of exploration and growth, we have gradually optimized our technology platform and organized a staff of excellent experts specialized in microfluidic and cell culture. We are dedicated to supporting cell culture services by developing high-quality microfluidic chips. If you are looking for a novel method to tackle your difficulties in cell culture, please don’t hesitate to contact us for more information.

Reference

  1. Garcia Alonso, D.; et al. Advances in microfluidics-based technologies for single cell culture. Adv Biosyst. 2019, 3(11): e1900003.

For Research Use Only. Not For Clinical Use.

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