Cell Culture Microfluidic Chip Development Service

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With the advent of microfluidic technology, methods of cell culture are meeting a technological revolution. A variety of unique advantages of microfluidic chips provides cell culture more possibilities. As a professional microfluidic chip development services provider, Creative Biolabs also keeps our eyes on microfluidic chip-based cell culture. With an advanced technology platform and rich experience, we are confident in providing high-quality microfluidic chip development services for cell culture.

Microfluidics Chip and Cell Culture

There is an immediate need to develop reliable tissue models for pre-clinical research. It costs $2.5 billion and 10-15 years on average to bring a drug to market. To decrease drug development costs, it is critical to improving pre-clinical screenings' predictive power for excluding ineffective/toxic candidates as early as possible. Currently, the typical workflow in pre-clinical tests is to screen drug candidates on statically cultured cells followed by animal (e.g., rodent) experiments. However, both models have inherent limitations. In this context, microfluidic technologies-based cell culture is born as a new platform in a more physiologically relevant manner. Microfluidics is devices with mm-scale fluidic channels for controlled flow in small volumes (mL). These cell-laden microfluidic devices are often referred to as organs-on-a-chip. This technology can overcome the limitations of both static cell cultures and animal studies.

Advantages of Microfluidics-based Cell Culture Platform
  • The inherent continuous flow in microfluidic devices enables continuous nutrient/oxygen supply and waste removal to maintain a stable growth environment for cells therein.
  • Flow manipulation can apply desired gradients to the cells, which is especially useful for dosing studies.
  • The laminar flow in microfluidic channels can mimic blood physics in capillaries shear stress can be introduced, and multiple cell types can be connected for inter-tissue modeling.
  • Human cells are commonly used to obviate the inter-species discrepancy of animal models.
  • With precise engineering, studying a single factor is more feasible with organs-on-a-chip than with animals.

Application of Microfluidic Chip in Cell Culture

Fig. 1 Microfluidic cell culture. (Perastrelo, et al., 2015)Fig. 1 Microfluidic cell culture.1

Services at Creative Biolabs

With years of experience focusing on the field of microfluidic chip development, Creative Biolabs has accumulated extensive experience from step-by-step practice. During this long period of exploration and growth, we have gradually optimized our technology platform and organized a staff of excellent experts specialized in microfluidic and cell culture. We are dedicated to supporting cell culture services by developing high-quality microfluidic chips. If you are looking for a novel method to tackle your difficulties in cell culture, please don’t hesitate to contact us for more information.

Reference

  1. Perastrelo, Aguas, et al. " Microfluidic Organ/Body-on-a-Chip Devices at the Convergence of Biology and Microengineering." Sensors 15.12 (2015): 31142-31170.

For Research Use Only. Not For Clinical Use.

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