Placenta-Organ-On-A-Chip Model Development Service

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Background Placenta-on-a-chip Published Data Applications Why Choose Us? FAQs Products

Creative Biolabs' Placenta-On-A-Chip Model Development Service offers a tailored solution to address your specific research needs related to placental function and dysfunction. We deliver fully functional, customized microfluidic platforms that accurately mimic the complex microenvironment of the human placenta. Our service provides you with a powerful tool to investigate placental transport, metabolism, and responses to various stimuli.

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Background

Functioning as a selective interface between maternal and fetal circulations, the placenta combines embryonic trophoblast layers with maternal decidual villi to orchestrate metabolic coordination. This gestational organ dynamically adjusts nutrient transport capacity through real-time fetal demand sensing while serving as a polyfunctional endocrine hub, producing over 100 regulatory molecules essential for pregnancy maintenance.

To decode this organ's complexity and xenobiotic interactions, scientific efforts have yielded engineered constructs replicating placental physiology through vascularized 3D cultures. These models enable functional assessment of villous integrity and transplacental exchange mechanisms, offering pathways to identify novel therapeutic targets and pregnancy complication interventions. Crucially, advanced dual-flow microfluidic systems now simulate the maternal-fetal blood interface with unprecedented fidelity. Notably, microfluidic placental models represent the most sophisticated platform for analyzing drug transplacental kinetics and trophoblast dynamics. Their capacity to mirror physiological transport barriers while maintaining hormonal cycling positions them as indispensable tools for developing pregnancy-safe pharmacotherapies and understanding maternal-fetal resource allocation pathologies.

Placenta-on-a-chip

Fig1. Different placental-on-a-chip models. (OA Literature) Fig1. Mimicking placental function on the chip.^1,3

A microfluidic placental interface system has been engineered to emulate critical placental features through the co-culture of vascular endothelium and cytotrophoblasts within stratified ECM hydrogels, coupled with perfusion-driven circulation. This platform enables continuous multimodal assessment of trophoblast migratory behavior and heterocellular communication via integrated biosensors. Parallel barrier models incorporating physiological hemodynamic profiles facilitate the simulation of nutrient transfer, drug permeation, and disease states within this gestational niche.

A complementary biofabrication strategy reconstructs the architectural complexity of maternal-fetal interfaces, modeling the spatiotemporal migration patterns of invasive cytotrophoblasts into decidualized stromal compartments. Utilizing clinical primary cell isolates, the system demonstrated physiological recapitulation of extravillous trophoblast infiltration into microvascular networks, along with endothelial-paracrine crosstalk essential for spiral artery remodeling – processes quantified through high-resolution live imaging and cytokine flux analysis.

Published Data

In Vitro Study of Caffeine Transport across Placental Barrier

Fig 2. The placenta‐on‐a‐chip consists of two layers of PDMS separated by a porous membrane and channel on each side.^2,3

A microfluidic model replicating human placental barriers was engineered to analyze transplacental substance transfer. Focusing on caffeine—a ubiquitous exogenous compound—the system quantified its permeability across gestational interfaces, critical given the fetal inability to metabolize this stimulant. The device biomimics maternal-fetal physiology through dual-channel architecture: one channel houses trophoblasts (BeWo) representing maternal epithelium, while the opposing channel contains fetal endothelial cells (HUVECs), separated by a microporous ECM-mimetic membrane facilitating nutrient/waste exchange.

This engineered placental interface enables real-time tracking of xenobiotic translocation kinetics. Caffeine exposure simulations revealed unregulated transbarrier transfer, highlighting potential teratogenic risks from maternal consumption. The platform's modular design supports customizable drug testing—maternal and fetal compartments permit simultaneous monitoring of compound diffusion rates and cellular responses. Validated through cyclic mechanical strain mimicking uterine contractions, the model advances pregnancy pharmacotherapy research by enabling risk-benefit analysis of medications under physiologically dynamic conditions.

Applications

Placenta-on-a-chip models have a wide range of applications in research and development, including:

Drug Discovery and Development: Evaluating the safety and efficacy of new drugs during pregnancy by accurately predicting placental drug transfer and metabolism.
Toxicology Studies: Assessing the effects of environmental toxins and pollutants on placental function and fetal development.
Disease Modeling: Investigating the mechanisms of placental dysfunction in pregnancy complications such as preeclampsia, gestational diabetes, and intrauterine growth restriction.
Nutrient Transport Studies: Understanding the transport of essential nutrients across the placenta and the impact of maternal nutrition on fetal growth.
Basic Research: Studying fundamental aspects of placental biology, such as placental development, differentiation, and hormone production.

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Why Choose Us?

Creative Biolabs offers several key advantages that set us apart:

Expertise: Our team comprises experienced scientists with deep expertise in microfluidics, cell biology, and placental physiology.
Customization: We offer fully customizable Placenta-On-A-Chip models tailored to your specific research needs and experimental design.
Advanced Technology: We utilize state-of-the-art microfabrication techniques and advanced cell culture methods to create physiologically relevant and reproducible models.
Comprehensive Support: We provide end-to-end support, from initial consultation and project design to data analysis and reporting.
Quality and Reliability: We adhere to the highest quality standards and rigorous validation procedures to ensure the accuracy and reliability of our models

FAQs

Q: Which compound classes can be assessed using your Placenta-On-A-Chip model?

A: Our system evaluates diverse analytes, including pharmacotherapeutics, nutritional agents, endocrine regulators, environmental toxicants, and engineered nanomaterials. Programmable flow parameters enable precise temporal control over dosage gradients, generating mechanistic insights into transbarrier permeation kinetics and maternal-fetal exchange pathways.

Q: How does the Placenta-On-A-Chip model advance beyond conventional in vitro assays?

A: The placenta-on-a-chip model surpasses static cell cultures through its perfusion-enabled architecture that recapitulates maternal-fetal hemodynamics. Bidirectional flow profiles and cyclic hypoxia gradients maintain placental cell polarity while enabling real-time analysis of nutrient carrier-mediated transport and efflux transporter activity – capabilities absent in conventional assays.

Q: Can the placenta-on-a-chip model be customized for specific research needs?

A: Yes, our Placenta-on-a-Chip model can be fully customized to meet your specific research needs. We can tailor the model's design, cell types, and experimental conditions to address your unique research questions. We work closely with you throughout the process to ensure that the model meets your exact requirements.

Recommended Products

For researchers facing challenges in initiating microfluidic cellular investigations de novo, Creative Biolabs' engineered cell-culture systems deliver integrated solutions that streamline workflow bottlenecks.

CBLcell™ Organ-on-chip Cell Culture Platform

Creative Biolabs provides you with a full range of microfluidic organ-on-a-chip and cell culture instruments and services to facilitate the start of your research to the greatest extent. If you are overwhelmed by starting a microfluidic cell experiment from scratch, Creative Biolabs' customized platform for cell culture can perfectly solve your problem.

Our chips offer the freedom to choose the cell seeding channels and perfusion conditions, enabling various cell culture modes.

CAT	Product Name	Application	Figure
MFMM1-GJS1	BE-Flow Standard	2D/3D cell culture and mechanical shear stress studies by means of microfluidics.
MFMM1-GJS3	BE-Transflow Standard	Construction of ALI interface and for organ chips such as lung, skin, intestine, cornea, etc.
MFMM1-GJS4	BE-Doubleflow Standard	Best choice for studying circulating particles, cell interactions, and simple organ-on-chip system construction.
MFMM-0723-JS1	Synvivo-SMN1 Microvascular Network Chips	Flow research Shear stress effect Vascular disease research Drug delivery Drug discovery Cellular behavior Cell-cell/particle interaction
MFCH-009	Synvivo-Idealized Co-Culture Network Chips (IMN2 Radial)	3D Blood Brain Barrier Model 3D Inflammation Model 3D Cancer Model 3D Toxicology Model
MFCH-010	Synvivo-Idealized Co-Culture Network Chips (IMN2 TEER)	3D Blood Brain Barrier Model 3D Inflammation Model 3D Cancer Model 3D Toxicology Model
MFCH-011	Synvivo-Idealized Co-Culture Network Chips (IMN2 Linear)	3D Blood Brain Barrier Model 3D Inflammation Model 3D Cancer Model 3D Toxicology Model 3D Lung Model 3D ALI Chip
MFCH-012	Synvivo-SMN2 microvascular network Co-Culture Chips	3D Inflammation Model 3D Cancer Model 3D Toxicology Model 3D Lung Model

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References

Deng, Zhi-Min, et al. "Organ-on-a-chip: future of female reproductive pathophysiological models." Journal of Nanobiotechnology 22.1 (2024): 455.
Pemathilaka, Rajeendra L., et al. "Placenta‐on‐a‐Chip: in vitro study of caffeine transport across placental barrier using liquid chromatography mass spectrometry." Global Challenges 3.3 (2019): 1800112.
Distributed under Open Access license CC BY 4.0, without modification.

For Research Use Only. Not For Clinical Use.