Ovary-Organ-On-A-Chip Model Development Service
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Background Ovary-on-a-chip Applications Why Choose Us? FAQs Products
Are you currently facing challenges in studying ovarian follicle development, reproductive toxicology, or developing new fertility preservation strategies? Creative Biolabs' Ovary-On-A-Chip Model Development Service offers a comprehensive solution for researchers seeking to advance their studies of ovarian function and related reproductive processes. We provide customized microfluidic devices that replicate the intricate three-dimensional structure and dynamic flow conditions of the native ovary, enabling more physiologically relevant in vitro studies.
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Background
The paired ovarian organs, positioned bilaterally flanking the uterus and linked via the uterine tubes, serve dual physiological roles in female reproduction. Their primary role involves gamete production—from puberty onward, these glands contain numerous follicular units housing immature ova. Simultaneously, ovarian endocrine activity regulates systemic physiology through steroid hormone synthesis (estrogens, progestogens, androgens) and growth mediator secretion. These biomolecules orchestrate multisystem functions spanning skeletal integrity, immunomodulation, neural signaling, and reproductive cyclicity while sustaining menstrual rhythm.
Fig 1. Ovaries and ovarian organ-on-a-chip.1,3
Currently, murine models remain the sole species achieving complete follicular development from primordial stages to live births via assisted reproduction. While pivotal for decoding conserved folliculogenesis mechanisms, translation to humans or livestock falters due to two biological constraints: extended maturation timelines and significant volumetric scaling. Consequently, effective in vitro systems for larger mammals require dynamic culture platforms that accommodate prolonged developmental phases and substantial structural expansion.
Ovary-on-a-chip
Organ-on-a-chip (OOC) platforms emulate living systems through biomimetic tissue architectures that maintain inter-organ communication while sustaining critical biological functions. These microphysiological systems surpass conventional preclinical approaches (static cultures and animal testing) through enhanced physiological accuracy, experimental reproducibility, and multi-tissue integration capabilities. Their modular design enables precise control over tissue-specific parameters, standardized culture conditions, and cost-effective scalability—advantages accelerating adoption across pharmacological screening and mechanistic pathophysiological investigations. This technological paradigm shift promises transformative impacts on therapeutic development and biomedical discovery.
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In vitro dynamic chip culture of follicle development
Ex vivo ovarian culture systems offer critical pathophysiological insights for reproductive biology and significant fertility preservation applications. This microfluidic-based platform integrates lab-grown follicular organoids with dynamic culture arrays. Ovarian units across species and developmental phases—including preantral, antral, and cumulus-oocyte complexes—are encapsulated within biomimetic matrices (variable-stiffness core-shell capsules, alginate hydrogels, or cortical tissue scaffolds) to replicate native ovarian microenvironments. Such engineered models advance mechanistic understanding of folliculogenesis while enabling systematic analysis of developmental modulators and ovulation triggers.
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Female menstrual cycle organ chips
The ovulatory cycle orchestrates intricate endocrine signaling across organs through precise spatiotemporal coordination, directing either embryogenesis initiation or cyclical endometrial renewal. Complementing miniaturized automation, organ-chip technology employs high-precision flow modulation to regulate biomolecular gradients. Leveraging this, scientists engineered a murine follicular interface generating human 28-day hormonal rhythms, synchronizing reproductive tract dynamics across modular units—single, dual, and multi-tissue configurations (Solo-MFP, Duet-MFP, Quintet-MPF).
Fig 2. Microfluidic platform supported follicle maturation and hormone secretion in the Solo-MFP.2,3
The Quintet-MPF platform incorporates five primary cellular modules (cervical, fallopian, murine ovarian, uterine, and hepatic tissues) into an integrated biochip system termed "EVATAR." Through controlled gonadotropin stimulation, ovarian components generate steroid and peptide hormones that interact dynamically with downstream reproductive tissues and hepatic counterparts. This multi-organ architecture enables novel applications in pharmacological innovation—from fertility modulation therapies to compound toxicity evaluation—by recapitulating systemic hormone-mediated responses.
Current investigations into ovarian epithelial cells' endocrine regulatory mechanisms remain incomplete, requiring urgent methodological refinement. Future studies will prioritize ultraprecise systems that synchronize with cyclical physiological oscillations. Innovations in ovarian pathophysiological platforms—such as vascular network engineering, biomechanical force emulation, and multi-tissue microphysiological integration—represent a transformative paradigm for addressing clinical subfertility.
Applications
Ovary-on-a-chip models have a wide range of applications in reproductive biology research and related fields. These include:
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Fundamental Research: Studying the basic mechanisms of ovarian follicle development, oocyte maturation, and hormone production.
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Drug Discovery and Development: Evaluating the effects of new drugs on ovarian function and identifying potential therapeutic targets for ovarian diseases.
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Reproductive Toxicology: Assessing the impact of environmental toxins and chemicals on ovarian health and fertility.
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Fertility Preservation: Developing new strategies for preserving female fertility, such as in vitro follicle culture and cryopreservation.
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Disease Modeling: Creating in vitro models of ovarian diseases, such as polycystic ovary syndrome (PCOS) and ovarian cancer, to study their pathogenesis and identify new treatment options.
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Endocrine Disruption: Investigating the effects of endocrine-disrupting chemicals on ovarian function and reproductive health.
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Why Choose Us?
Creative Biolabs' Ovary-On-A-Chip Model Development Service offers several key advantages:
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Customized Solutions: We understand that each research project is unique. We work closely with our clients to design and fabricate customized microfluidic devices that meet their specific needs and experimental requirements.
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Physiological Relevance: Our Ovary-On-A-Chip models are designed to accurately mimic the complex microenvironment of the native ovary, providing a more physiologically relevant platform for studying ovarian function and related processes.
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Expertise and Experience: Our team comprises experienced scientists and engineers with expertise in microfluidics, cell biology, and reproductive biology.
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Advanced Technology: We utilize state-of-the-art microfabrication techniques and advanced imaging and analysis tools to ensure the quality and reliability of our Ovary-On-A-Chip models.
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Comprehensive Support: We provide comprehensive support throughout the entire project lifecycle, from initial consultation and device design to experimental execution, data analysis, and reporting.
FAQs
Here are some frequently asked questions from potential customers interested in our Ovary-On-A-Chip Model Development Service:
Q: Are species-specific or stage-targeted ovarian modeling configurations achievable?
A: Our expertise lies in engineering bespoke organ-on-chip models that replicate interspecies biological variations and precise developmental chronology. Through collaborative consultation, we architect species- and stage-precise ovarian platforms mirroring your experimental pathophysiology requirements.
Q: What are the advantages of using an Ovary-On-A-Chip model compared to traditional cell culture methods?
A: Ovary-On-A-Chip models offer several advantages over traditional 2D cell cultures, including improved physiological relevance, better control over the microenvironment, and the ability to study dynamic processes. These models provide a more accurate and predictive platform for studying ovarian function and the effects of various factors.
Q: What kind of data can be generated using the Ovary-On-A-Chip model?
A: The Ovary-On-A-Chip model can be used to generate a wide range of data, including cell viability, hormone production, gene expression, and morphological changes. The specific data types will depend on your experimental design and the analytical techniques employed.
Recommended Products
For researchers facing challenges in initiating microfluidic cellular investigations de novo, Creative Biolabs' engineered cell-culture systems deliver integrated solutions that streamline workflow bottlenecks.
CBLcell™ Organ-on-chip Cell Culture Platform
Creative Biolabs provides you with a full range of microfluidic organ-on-a-chip and cell culture instruments and services to facilitate the start of your research to the greatest extent. If you are overwhelmed by starting a microfluidic cell experiment from scratch, Creative Biolabs' customized platform for cell culture can perfectly solve your problem.
Our chips offer the freedom to choose the cell seeding channels and perfusion conditions, enabling various cell culture modes.
For more information about Creative Biolabs products and services, please contact us.
References
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Deng, Zhi-Min, et al. "Organ-on-a-chip: future of female reproductive pathophysiological models." Journal of Nanobiotechnology 22.1 (2024): 455.
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Xiao, Shuo, et al. "A microfluidic culture model of the human reproductive tract and 28-day menstrual cycle." Nature Communications 8.1 (2017): 14584.
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Distributed under Open Access license CC BY 4.0, without modification.
For Research Use Only. Not For Clinical Use.
