As lipid-based delivery systems continue to expand across drug delivery, gene delivery, vaccine research, diagnostic imaging, and functional biomaterials, the demand for precise synthesis technologies has grown significantly. Microfluidics has become an attractive platform because it enables controlled self-assembly under well-defined flow conditions, overcoming many of the variability issues commonly seen in conventional bulk preparation methods.
Creative Biolabs' service is designed for clients who need more than simple particle preparation. We help transform experimental concepts into robust microfluidic workflows by considering formulation composition, solvent systems, aqueous phase design, chip architecture, flow parameters, mixing strategy, and downstream characterization as one integrated development pathway. This allows us to support both exploratory feasibility studies and more structured preclinical development programs.
Our Service Portfolio
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Service Content
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Descriptions
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Custom Formulation Strategy Design
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At this stage, we work closely with clients to understand the intended payload, target biological environment, administration scenario, stability requirements, particle size window, and desired release behavior. These inputs are translated into rational choices regarding lipid classes, helper lipids, cholesterol ratios, PEGylation levels, charge characteristics, and solvent composition.
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Microfluidic Process Development
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After defining the formulation direction, our scientists establish a microfluidic synthesis workflow tailored to the physicochemical properties of the system. We select or recommend suitable chip layouts and mixing modes, such as hydrodynamic focusing or mixer-assisted architectures, based on the level of control required and the complexity of the formulation. Parameters including total flow rate, flow rate ratio, solvent exchange profile, and residence time are then systematically optimized.
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Lipid and Solvent Compatibility Assessment
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Our team evaluates lipid solubility, solvent behavior, aqueous phase conditions, buffer composition, pH range, and possible precipitation risks during rapid mixing. We also consider whether the formulation requires mild conditions to preserve bioactive payloads or specialized solvent-removal and buffer-exchange strategies after formation.
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Encapsulation-Oriented Development
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For projects involving active ingredients, our service can be organized around encapsulation objectives. We assist clients in designing lipid systems for small molecules, peptides, proteins, nucleic acids, dyes, imaging probes, and exploratory functional compounds. Depending on the payload and desired localization, we optimize parameters related to loading strategy, phase partitioning, membrane retention, and post-formation processing.
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Particle Characterization Support
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To ensure that synthesis results are actionable, we provide or support comprehensive particle characterization workflows. Typical characterization endpoints may include particle size, polydispersity index, zeta potential, morphology, colloidal stability, encapsulation efficiency, loading content, and release-related properties. For more advanced studies, characterization may be expanded toward lamellarity, phase behavior, structural imaging, and storage stability under project-specific conditions.
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Client Testimonials
"We were looking for a partner that could do more than simply prepare liposomes. What impressed us most about Creative Biolabs was their ability to understand the formulation logic behind our project. Their team helped us evaluate lipid composition, optimize flow parameters, and improve particle uniformity in a way that significantly strengthened our early-stage development work."
— Scientist, Biopharmaceutical R&D Team
"Our project involved microfluidic formulation of lipid vesicles for nucleic acid delivery, and reproducibility was a major concern from the very beginning. Creative Biolabs provided a structured optimization strategy instead of trial-and-error suggestions. Their support gave us much greater confidence in the consistency of our synthesis process and the comparability of our batches."
— Principal Investigator, Nucleic Acid Delivery Program
"We appreciated the combination of technical depth and communication efficiency. The team did not just send us data; they explained the rationale behind each optimization step and helped us interpret how process conditions were affecting particle size, distribution, and encapsulation behavior. That level of transparency made the collaboration highly productive."
— Senior Research Manager, Translational Nanomedicine Group
"Creative Biolabs supported us during a formulation screening project in which we needed to compare multiple lipid systems under controlled microfluidic conditions. Their workflow design was thoughtful, and the resulting data were well organized and useful for decision-making. We especially valued their attention to reproducibility and practical application relevance."
— Formulation Development Lead, Drug Delivery Company
Published Data
High-throughput microfluidic production of ultrasmall lecithin nanoliposomes
The researchers introduced an HBSCF device and optimized the synthesis parameters, such as total flow rate (TFR, the sum of the internal and external phase flow rates) and flow rate ratio (FRR, external phase: internal phase), to produce lecithin-based nanoliposomes with particle sizes below 40 nm with an excellent homogeneity (PDI < 0.2), while obviating the use of the synthetic surfactants. The ability of NLPUS to load a variety of anti-aging agents without altering their particle size or homogeneity demonstrates the versatility of this system as a drug carrier.
Fig.1 Schematic representation of the procedure for the synthesis of liposomes.1,2
References
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Liang, Xiao, et al. "High-throughput microfluidic production of ultrasmall lecithin nanoliposomes for high-efficacy transdermal delivery and skin-aging treatment." Biomedicines 13.2 (2025): 322. https://doi.org/10.3390/biomedicines13020322
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Distributed under Open Access license CC BY 4.0, without modification.
Created February 2026
