Creative Biolabs develops and constructs microreactors for clients all over the world to help biologists or chemists better carry out their research.
The microstructure reactor is a device that uses lower lateral dimensions to confine the reaction. The liquid microreactor was originally established for nuclear research, which shows the handling advantage to hazardous and highly exothermic reactions at the microscale. Compared with traditional glass containers, microreactors have irreplaceable advantages.
Fig 1. Customizable multivariate modules will be the biggest advantage of micro reactors. (Huang, et al., 2019)
In addition, the closed structure of the microchannels allows the acceleration of the reaction by raising the temperature above the boiling point of the solvent or direct pressurization. The advantages of microchannel reactors make them valuable tools in the hands of chemists, biologists, or reaction engineers and are widely used in the fields of analysis, diagnostics, pharmaceuticals, synthesis, and biotechnology.
Enzymes can be immobilized on different supports in flow systems, these miniaturized reactors have good substrate specificity, easy product separation and operation. By using different biomolecules, microchips can be used as liquid chromatography chips for electrochemical, optical and mass spectrometry detection. By immobilizing proteolytic enzymes in the chip, the microreactor can realize protein digestion in a short time. In addition, through molecular synthesis, functional group conversion and product signal amplification can also be achieved through different enzymatic reactions. Creative Biolabs has all the experiences and resources that allow us to bond a variety of biomolecules commonly used in immunoassay experiments and mass spectrometry (e.g., proteins, DNA, RNA, antigens, antibodies) to suitable solid supports. We can also bind multiple molecules together/sequentially to achieve more complex functions according to your needs.
Fig 2. Enzymes can be bound to the surface of various supports and exert their functions. (Kecskemeti, et al., 2017)
Green chemistry and compact systems are the main trends in the development of the chemical industry, which is the main advantage of microreactors. In the process of chemical synthesis, microreactors can synthesize molecules quickly and efficiently, which is mainly due to its excellent thermodynamics, higher surface area to volume ratio, engineering advantages for effective handling of intermediates, and online purification modules for products. Microreactors significantly improve the safety of operations with a higher degree of product, even in some dangerous and difficult experiments. In the liquid-phase degradation process, through material modification and the introduction of magnetic, optical, and electrical structural units, microreactors often have higher catalytic treatment efficiency and product purity. Extraction processes performed at the microscopic level also have advantages over macroscopic experiments, including higher mass transfer coefficients, shorter extraction times and excellent S/V ratios, which minimize reaction times and reactant volumes. Creative Biolabs will help you to transfer macro experiments to micro-scale structures. With our help, you are capable of exploring and optimizing the best process parameters to achieve better reaction product conversion and molecular characteristics.
Fig 3. Chemical overview of a reactor system with four reactor combinations. (Kandelhard, et al., 2021)
We will combine and utilize knowledge of engineering, biology and chemistry to help you design and fabricate microreactor chips with suitable functions. With our help and appropriate operations in the microchannel, you may build a microscale experimental platform with excellent safety, reliability and scalability that suits your project, so don't hesitate to contact us for more information.
For Research Use Only. Not For Clinical Use.