Multi-Organ-On-A-Chip Model Development Service

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Background Typical and Advanced Model Services Features Q&As Resources

Organ-on-a-chip technology aims to reproduce the key physiological characteristics of human organs and tissues. At Creative Biolabs, we provide customized multi-organ chips that connect multiple organs and reproduce complex and dynamic interactions in the human body.

Multi-Organ-On-A-Chip Model

The difficulties in drug development and disease research often come from the fact that oversimplified in vitro culture models show limited relevance to human body structures and only have partial cellular physiological responses, while animal models are often time-consuming and laborious but cannot be accurately inferred. By combining microfabrication technology and physiological knowledge, Creative Biolabs provides our clients with organ chips that can precisely control three-dimensional geometry, fluid flow and molecular transport, and accurately reconstruct the tissue microenvironment in vitro. Through precise manipulation of experimental conditions, microfluidic chips can connect multiple organs and allow communication between them, making the exploration of complex and dynamic interactions and crosstalk between multiple organs a reality.

Fig. 1 Multi-organ chips conduct exploration under human physiological or pathological conditions, through different organ combinations. Fig. 1 The microenvironmental characteristics of the gut are the key to building a gut-on-a-chip.^1,3

Typical and Advanced Multi-Organ-On-A-Chip Model

Many diseases, including obesity, immunodeficiency, and diabetes, show complex mechanisms involving different organs, and multi-organ chips will be the best tools for research and exploration of such diseases. Different from the organ-on-a-chip that summarizes the structure and function of a single organ, the multi-organ-on-a-chip aims to integrate multiple organs on a single platform. The multi-organ chip reproduces the absorption, distribution and metabolism of dynamic drugs in the state of multi-organs through interconnected microcavities. The design of a multiorgan-on-a-chip will vary depending on the specific aspects of interest, and the organs chosen will vary depending on the research direction and disease model. Intestinal chips for simulating drug absorption and liver chips for drug metabolism are most commonly used in multi-organ tissues. Other tissues, including kidney chips, skeletal muscle chips, brain chips, and cancer tissue chips are also widely chosen. Through the combination of different organs and the addition of functional elements, disease models can be accurately reproduced and drug efficacy can be thoroughly evaluated in vitro.

Fig. 2 Characterization of a heart-liver chip. Fig. 2 Establishment and characterization of a heart-liver chip. ^2,3

In addition to applications in drug discovery and disease modeling, another multi-organ-on-a-chip application area is the study of cancer metastasis. Custom multi-tissue transfer chips can contain any number of organoids, enabling cancer cells to metastasize from one site to another to recapitulate dissemination of circulating tumor cells. We believe that with our comprehensive and reliable custom services, multi-organ cancer metastasis microarray can help our customers to better understand cancer biology and make significant progress in drug discovery.

Our Services

With our powerful processing platform and years of experience in histology, Creative Biolabs provides custom design and processing services for multi-organ chips to clients all over the world. Through our services, you can build your own continuous and stable test model, and the tailor-made organ-on-a-chip system will provide you with ideal pharmacokinetic, pharmacodynamic and pathological outcomes. Our custom chip with well-defined and reproducible physiological functions will be your best choice for drug testing and pathological research, so don’t hesitate to contact us for more information.

References

Berlo, D.; et al. The potential of multi-organ-on-chip models for assessment of drug disposition as alternative to animal testing. Current Opinion in Toxicology. 2021, 27: 8-17.
Zhao, Y.; et al. Multi-organs-on-chips: Towards long-term biomedical investigations. Molecules. 2019, 24: 675.
under Open Access license CC BY 4.0, without modification.

Features and Benefits

Integrated Organ Systems

Multi-Organ-On-A-Chip models simulate the interactions between different organs, providing a more comprehensive understanding of systemic biology. This enables researchers to study complex physiological processes and disease mechanisms that involve multiple organs.

Physiologically Relevant Microenvironment

These models replicate the in vivo microenvironment of various organs, allowing for more accurate studies of organ functions, interactions, and responses to drugs. This enhances the relevance and translatability of research finding.

Versatile Application Range

These models are suitable for a wide range of applications, including studying disease mechanisms, drug absorption and metabolism, toxicity testing, and personalized medicine. This versatility makes them invaluable tools for various aspects of biomedical research.

Multi-Scale Integration

These models can integrate cellular, tissue, and organ-level functions, providing a holistic view of biological processes. This multi-scale approach enhances the ability to study intricate interactions within and between different organ systems.

Reduction in Animal Testing

By providing a more accurate in vitro model of human organ systems, Multi-Organ-On-A-Chip reduces the reliance on animal testing. This aligns with ethical standards, decreases research costs, and speeds up the drug development process.

Q&As

Q: What types of organs can be modeled in Multi-Organ-On-A-Chip systems?

A: Various organs can be modeled, including the liver, heart, lungs, kidneys, intestines, and more. The system can be customized to include specific organ combinations relevant to the research question, enabling comprehensive studies of multi-organ interactions.

Q: What is the typical workflow for a Multi-Organ-On-A-Chip experiment?

A: The typical workflow includes designing the microfluidic device, seeding the devices with appropriate cell types for each organ, maintaining the cultures under controlled conditions, treating with experimental compounds, and monitoring responses using various analytical techniques. Data is then analyzed to understand organ-specific and systemic effects.

Q: What role does fluid dynamics play in Multi-Organ-On-A-Chip models?

A: Fluid dynamics are crucial in Multi-Organ-On-A-Chip models as they simulate the blood flow and shear stress experienced by organs in vivo. Proper fluid dynamics ensure that cells experience physiologically relevant conditions, which is essential for maintaining cell function and accurately modeling organ interactions.

Q: How scalable are Multi-Organ-On-A-Chip models for large-scale studies?

A: Multi-Organ-On-A-Chip models are increasingly scalable due to advancements in microfabrication and automation technologies. This scalability allows for high-throughput screening and large-scale studies, making it feasible to conduct extensive research on drug effects and disease mechanisms.

Q: What quality control measures are in place for Multi-Organ-On-A-Chip experiments?

A: Quality control measures include validating the functionality and viability of each organ model, ensuring proper fluid flow and connectivity between organs, and regularly monitoring cellular responses. These measures ensure that the data generated is reliable and reproducible.