Multi-Organ-On-A-Chip Model Development Service
Inquiry
Organ-on-a-chip technology aims to reproduce the key physiological characteristics of human organs and tissues. At Creative Biolabs, we provide customized multi-organ chips that connect multiple organs and reproduce complex and dynamic interactions in the human body.
Multi-Organ-On-A-Chip Model
The difficulties in drug development and disease research often come from the fact that oversimplified in vitro culture models show limited relevance to human body structures and only have partial cellular physiological responses, while animal models are often time-consuming and laborious but cannot be accurately inferred. By combining microfabrication technology and physiological knowledge, Creative Biolabs provides our clients with organ chips that can precisely control three-dimensional geometry, fluid flow and molecular transport, and accurately reconstruct the tissue microenvironment in vitro. Through precise manipulation of experimental conditions, microfluidic chips can connect multiple organs and allow communication between them, making the exploration of complex and dynamic interactions and crosstalk between multiple organs a reality.
Fig 1. Multi-organ chips conduct all-round exploration under human physiological or pathological conditions, through different organ combinations. (Berlo,2021)
Typical and Advanced Multi-Organ-On-A-Chip Model
Many diseases, including obesity, immunodeficiency, and diabetes, show complex mechanisms involving different organs, and multi-organ chips will be the best tools for research and exploration of such diseases. Different from the organ-on-a-chip that summarizes the structure and function of a single organ, the multi-organ-on-a-chip aims to integrate multiple organs on a single platform. The multi-organ chip reproduces the absorption, distribution and metabolism of dynamic drugs in the state of multi-organs through interconnected microcavities. The design of a multiorgan-on-a-chip will vary depending on the specific aspects of interest, and the organs chosen will vary depending on the research direction and disease model. Intestinal chips for simulating drug absorption and liver chips for drug metabolism are most commonly used in multi-organ tissues. Other tissues, including kidney chips, skeletal muscle chips, brain chips, and cancer tissue chips are also widely chosen. Through the combination of different organs and the addition of functional elements, disease models can be accurately reproduced and drug efficacy can be thoroughly evaluated in vitro.
Fig 2. Establishment and characterization of a heart-liver chip. (Zhao, 2019)
In addition to applications in drug discovery and disease modeling, another multi-organ-on-a-chip application area is the study of cancer metastasis. Custom multi-tissue transfer chips can contain any number of organoids, enabling cancer cells to metastasize from one site to another to recapitulate dissemination of circulating tumor cells. We believe that with our comprehensive and reliable custom services, multi-organ cancer metastasis microarray can help our customers to better understand cancer biology and make significant progress in drug discovery.
Our Services
With our powerful processing platform and years of experience in histology, Creative Biolabs provides custom design and processing services for multi-organ chips to clients all over the world. Through our services, you can build your own continuous and stable test model, and the tailor-made organ-on-a-chip system will provide you with ideal pharmacokinetic, pharmacodynamic and pathological outcomes. Our custom chip with well-defined and reproducible physiological functions will be your best choice for drug testing and pathological research, so don’t hesitate to contact us for more information.
References
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Berlo, D.; et al. The potential of multi-organ-on-chip models for assessment of drug disposition as alternative to animal testing. Current Opinion in Toxicology. 2021, 27: 8-17.
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Zhao, Y.; et al. Multi-organs-on-chips: Towards long-term biomedical investigations. Molecules. 2019, 24: 675.
For Research Use Only. Not For Clinical Use.
