Microfluidic Chip Development Service for DNA Sequencing
Inquiry
As a world-leading service provider of microfluidic chip development, Creative Biolabs has accumulated extensive experience from the accomplishment of different projects, during which we have received a lot of recognition and praise from our clients. Nowadays, we provide various microfluidic-based solutions for the DNA sequencing technology to facilitate nucleic acid analysis in a broad range of practical applications.
Why perform DNA Sequencing on Microfluidic Chips?
DNA sequencing is considered as a promising method for nucleic acids analysis and many machines that are designed for sequencing target genes have been developed for a range of applications. Meanwhile, several microfluidic chips have been utilized to improve the accuracy and sensitivity of DNA sequencing systems. The microfluidics chip is usually composed of several oil-filled channels to help separate different liquids in the system. Different magnetic particles are further used to regulate the movement of targets and the rest of the molecules. Pilot studies showed that microfluidic chips are capable of controlling the liquid at a trace level, isolating target genes from the whole genome, as well as enriching genes for DNA sequencing. Moreover, recent reports indicate that microfluidic chip-based next-generation sequencing (NGS) technology has emerged, providing a unique DNA screening opportunity for producing a large number of short reads with high genome coverage. Besides, a panel of microfluidic access arrays has been designed for the generation of enriched sequencing libraries.
Fig. 1 Microfluidic droplet-based target enrichment.1,3
What Service we offer for DNA Sequencing on Microfluidic Chips?
Microfluidic-based DNA sequencing technology can divide DNA molecules into millions of microdroplets to achieve a high-throughput screening cost-effectively. As an expert in microfluidic chip development, Creative Biolabs has generated many microfluidic chips, such as capillary electrophoresis (CE) chips and droplet-based microfluidic chips for increasing the efficiency of DNA sequencing. For instance, our CE chips can complete DNA sequencing with an accuracy of more than 95% and analyze approximately 160 bases in 10 minutes. Furthermore, our droplet-based microfluidic chips are capable of obtaining thousands of drops per second. Moreover, these chips can be used to test target sequences with a length of 15 bases in a series of flowing droplet reactions. Besides, we also provide a full range of microfluidic chip optimization assays, including the separation matrix selection, channel, and injector size optimization, for our worldwide customers to improve DNA sequencing performance.
To help our clients develop an accurate and effective DNA sequencing technology, Creative Biolabs offers the most comprehensive, integrated portfolio of microfluidic chip products and solutions. If you are interested in our services, please contact us for more details. Let us know what you need and we will accommodate you. We look forward to working with you in the future.
Published Data
The findings discussed in the articles related to DNA sequencing on microfluidic chips are presented here:
1. High-throughput automated microfluidic sample preparation for accurate microbial genomic.
Fig. 2 Genomic sample preparation device operation and performance.2,3
Soohong Kim et al. introduced a microfluidic sample preparation platform for cell sequencing library construction. This platform has some advantages. It can sequence up to 96 samples. It has the capability to decrease the need for DNA input by a factor of 100, all while preserving or enhancing the quality of the data. This automated microfluidic system integrates all key steps of sequencing sample preparation, including cell concentration, lysis, fragmentation, adapter labeling, fragment purification and particle size selection. Each microfluidic device can run batch sizes up to 96 samples.
References
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Eastburn, Huang, et al. " Microfluidic droplet enrichment for targeted sequencing." Nucleic Acid Res. 43.13 (2015): e86.
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Kim, Soohong, et al. "High-throughput automated microfluidic sample preparation for accurate microbial genomics." Nature communications 8.1 (2017): 13919.
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Distributed under Open Access license CC BY 4.0, without modification.
For Research Use Only. Not For Clinical Use.
