Are you currently facing long drug development cycles, difficulty in pinpointing genetic markers, or complex clinical trial processes? Creative Biolabs' Microfluidic Chip Development Service for Gene Rearrangements Detection helps you streamline clinical trial processes and accelerate drug discovery through the use of advanced microfluidic platforms and innovative assay integration.
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Background
Gene rearrangement constitutes a genomic alteration involving abnormal genetic modifications such as copy number shifts, fragment recombination, and expression profile changes. Typically, this results from DNA double-strand breakage, followed by rejoining of severed ends to form novel gene sequences differing from pre-breakage chromosomal arrangements. Contemporary classifications divide gene rearrangements into two types: stochastic and programmed occurrences. Stochastic rearrangements emerge during genetic replication, repair, or recombination processes. Evidence indicates these alterations are frequently unforeseeable, with most proving detrimental to well-being. Conversely, programmed rearrangements represent inherent biological progression within organisms and their progeny. Virtually all outcomes of such rearrangements become detectable through specific enzymatic methodologies.
Fig. 1 Common gene rearrangements in cancer cells.1,3
Accurate and rapid detection of these rearrangements is essential for clinical diagnostics, prognosis, and therapeutic decision-making. Traditional methods like fluorescence in situ hybridization (FISH) and quantitative PCR (qPCR) have long been the gold standard, but they often require large sample volumes, are labor-intensive, and can have limited throughput. Next-generation sequencing (NGS) offers a comprehensive view but can be costly and time-consuming.
Microfluidics represents a significant leap forward for gene rearrangement detection, offering a solution to the limitations of traditional methods. By precisely controlling tiny fluid volumes, this technology enables the miniaturization of complex workflows, from sample preparation to detection, onto a single chip. This platform is uniquely suited for analyzing precious and minute samples, such as liquid biopsies, with unprecedented efficiency. It allows for high-throughput, multiplexed analysis, meaning you can screen for multiple gene fusions or translocations in parallel, drastically reducing turnaround time. The automation inherent in these systems also minimizes manual intervention and the risk of human error, while published data confirms a boost in sensitivity, allowing for the detection of rare genetic biomarkers. Our service harnesses this transformative technology, providing a comprehensive solution that moves beyond the limitations of conventional methods.
Applications
Our microfluidic solutions have a wide range of applications across the life sciences and clinical diagnostics.
Oncology and Cancer Research
Early detection and monitoring of cancer-related gene fusions and translocations in patient biopsies and liquid biopsies.
Drug Discovery & Development
High-throughput screening for the identification of drug targets and the evaluation of therapeutic efficacy in preclinical models.
Prenatal Diagnostics
Non-invasive prenatal testing (NIPT) for the detection of chromosomal abnormalities and genetic disorders.
Pathogen Detection
Rapid and sensitive identification of viral and bacterial gene rearrangements for infectious disease diagnostics.
Personalized Medicine
Tailoring treatment strategies based on an individual's unique genetic profile and biomarkers.
What We Can Offer
Creative Biolabs provides a complete suite of services to support your gene rearrangement detection needs, from concept to final product.
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Custom Microfluidic Chip Fabrication: We design and manufacture bespoke microfluidic chips tailored to your specific application, whether for research or clinical use.
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One-Stop Microfluidic Solution: We offer an end-to-end service, handling everything from initial design and prototyping to assay integration and final product manufacturing.
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Standard Microfluidic chips: We also offer a selection of pre-designed, validated microfluidic chips for common research applications, providing a quick and reliable solution without the need for custom development.
Leverage our specialized benefits—Request a quotation today
Workflow
Why Choose Us
Choosing Creative Biolabs means partnering with a team that offers unparalleled expertise and technology. Our microfluidic platforms provide significant advantages over traditional methods, ensuring your project is completed with superior speed, sensitivity, and cost-efficiency.
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Speed and Efficiency: By miniaturizing and integrating multiple steps onto a single chip, our service dramatically reduces manual handling and overall turnaround time.
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Reduced Sample Consumption: Our microfluidic chips require only microliter or nanoliter volumes, which is crucial for precious or scarce clinical samples.
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High Throughput and Multiplexing: We enable the analysis of numerous samples and the simultaneous detection of multiple gene rearrangements, accelerating your research.
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Enhanced Sensitivity: Published data indicates that microfluidic-based assays can achieve higher sensitivity, allowing for the detection of low-abundance genetic targets.
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Seamless Integration: Our one-stop solution integrates sample preparation, reaction, and detection into a single, automated workflow, minimizing human error and cross-contamination.
FAQs
Q: How do you select the optimal material for a microfluidic chip?
A: The selection of an optimal chip material is critical for assay performance. We consider several factors, including the required chemical compatibility with your reagents, optical transparency for detection methods, and biocompatibility with the biological samples. Common materials include polydimethylsiloxane (PDMS) for rapid prototyping and flexibility, as well as glass and various polymers for applications requiring higher chemical resistance or specific surface properties.
Q: How does the cost-effectiveness of microfluidic technology compare to conventional methods?
A: While there is an initial investment in custom chip development, the long-term cost savings are substantial. Microfluidic systems drastically reduce the volume of expensive reagents and the amount of precious sample required per test. Furthermore, the high throughput and automation of the process reduce labor costs and increase efficiency, leading to a lower cost per data point over the project lifecycle.
Q: Is it possible to perform multiplexed detection of multiple gene rearrangements on a single chip?
A: Yes, multiplexing is a core advantage of microfluidic platforms. By designing a chip with multiple reaction chambers and microchannels, we can enable the simultaneous detection of numerous gene targets from a single sample. This capability is essential for comprehensive genetic screening in areas like cancer diagnostics, where a single sample may need to be screened for a panel of gene fusions or translocations.
Q: What are the key performance benefits of using a microfluidic approach for genetic analysis?
A: Microfluidics offers superior performance through several key benefits. The miniaturization of reaction volumes leads to enhanced sensitivity by concentrating the target molecules, allowing for the detection of rare genetic biomarkers. The integrated, automated workflow reduces manual handling, minimizing the risk of contamination and improving reproducibility. The overall process is significantly faster and more efficient, enabling quicker turnaround times for critical research and clinical decisions.
Creative Biolabs is your partner in microfluidic innovation. We provide a comprehensive service for the development of custom microfluidic chips, offering unparalleled expertise and a one-stop solution to accelerate your genetic research and diagnostic projects. Our commitment to quality, efficiency, and customer satisfaction ensures you receive a product that is not only scientifically sound but also perfectly aligned with your project's goals.
Featured Services
Feature Products
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CAT No
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Material
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Product Name
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Application
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MFCH-001
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Glass
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Herringbone Microfluidic Chip
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Processing samples and reagents in Nucleic acid analysis, blood Analysis, immunoassays and point-of-care diagnostics.
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MFMM-0723-JS12
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Glass
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Double Emulsion Droplet Chip
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Our double emulsion microfluidic chip, incorporating localized modifications and a classic flow-focusing structure, is specifically designed to generate stable and uniform double emulsion droplets.
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MFCH-005
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PDMS
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3D Cell Culture Chip-Neuron
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Neuron cell culture and study of axon transport, axon protein synthesis, axon damage/regeneration, signal transduction of axon to somatic signal.
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MFCH-009
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PDMS
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Synvivo-Idealized Co-Culture Network Chips (IMN2 radial)
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SynBBB 3D Blood Brain Barrier Model/SynRAM 3D Inflammation Model/SynTumor 3D Cancer Model/SynTox 3D Toxicology Model
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MFMM1-GJS4
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COC
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BE-Doubleflow Standard
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Studying circulating particles, cell interactions and simple organ on chip system construction.
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MFMM1-GJS6
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COC
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BE-Transflow Custom
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Used to construct cell interface or Air-Liquid interface (ALI) to study more complex culture systems.
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Click here to Explore our complete product catalog.
Consult our specialists for detailed insights and project-specific deliberations.
References
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Alshalalfa, Mohammed et al. "Detecting cancer outlier genes with potential rearrangement using gene expression data and biological networks." Advances in bioinformatics vol. 2012 (2012): 373506. https://doi.org/10.1155/2012/373506
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Fergola, Andrea et al. "Droplet Generation and Manipulation in Microfluidics: A Comprehensive Overview of Passive and Active Strategies." Biosensors vol. 15,6 345. 29 May. 2025, https://doi.org/10.3390/bios15060345
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Distributed under Open Access license CC BY 4.0, without modification.
