Are you currently facing long drug development cycles, difficulty in protein expression and purification, or complex clinical trials? Creative Biolabs' Microfluidic Chip Development Service helps you accelerate genetic discovery, obtain high-quality data, and streamline your research and development processes through advanced high-throughput screening platforms and innovative chip engineering techniques.
Contact our team to get an inquiry now!
Background
Microsatellite DNA, also known as Short Tandem Repeats (STRs), are short, non-coding, repetitive DNA sequences found throughout the genome. The number of repeats at a given locus can vary between individuals, making them highly valuable as polymorphic genetic markers. Due to their high mutation rate and ubiquitous nature, microsatellites are crucial for applications ranging from population genetics and disease association studies to forensics and paternity testing.
Fig. 1 Microfluidic gene screening.1,3
Established techniques for microsatellite assessment frequently entail cumbersome and laborious procedures like PCR coupled with gel-based or capillary electrophoretic separation. These approaches demand substantial specimen quantities and chemical reagents, exhibit limited throughput capacity, and resist automation. Microfluidic device innovation presents a transformative approach. Through fabricating miniaturized, complex channel networks on substrates, microfluidic systems permit exact control over nanoliter-scale liquid volumes. This methodology facilitates consolidating diverse laboratory operations—including nucleic acid amplification, tagging, and analysis—within a unified automated framework. Consequently, it constitutes an enhanced efficiency, high-capacity, and economically optimized substitute for classical techniques. Our systems, for instance, execute numerous concurrent assays within picoliter-volume droplets, markedly advancing assay throughput and analytical precision.
Applications
The applications of our microfluidic technology for microsatellite DNA detection are vast and diverse, enabling new breakthroughs in various fields.
Plant and Animal Breeding
Rapidly screen for genetic markers associated with desirable traits, accelerating the development of higher-yield crops and more resilient livestock.
Forensic Science
Perform high-throughput DNA fingerprinting for human identification and criminal investigations.
Paternity and Family Relationship Testing
Accurately determine biological relationships with minimal sample volume.
Disease Diagnosis and Research
Identify genetic markers linked to diseases, enabling early detection and personalized medicine.
Population and Evolutionary Genetics
Analyze large-scale genetic variation within and between populations to study evolutionary history and biodiversity.
What We Can Offer
Creative Biolabs is your complete partner in microfluidic technology. We provide a full suite of services and products to support your research from start to finish.
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Custom Microfluidic Chip Fabrication: We design and fabricate bespoke microfluidic chips tailored to your specific assay requirements.
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One-Stop Microfluidic Solutions: From initial design and simulation to final validation and integration, we provide a complete, end-to-end service, delivering a fully functional system to your lab.
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Microfluidic Chip Products: We offer a range of pre-designed chips for common applications that can be customized to your needs, providing a faster and more cost-effective entry point into microfluidic technology.
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Consumables and Reagents: We can provide optimized reagents and consumables for use with our microfluidic platforms, ensuring the highest performance and reliability.
Leverage our specialized benefits—Request a quotation today
Workflow
Why Choose Us
Choosing Creative Biolabs means partnering with a team dedicated to innovation and scientific excellence. Our microfluidic platforms are engineered to provide superior performance, offering significant advantages over conventional methods.
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High-Throughput and Automation: Our programmable, droplet-based platforms, akin to the systems described in published data, can process an unrestricted number of DNA samples against a panel of markers, eliminating the throughput limitations of traditional devices. This flow-based operation functions like a high-speed assembly line, processing thousands of data points without idle time.
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Cost-Efficiency and Miniaturization: By miniaturizing reaction volumes into picoliter to nanoliter droplets, our chips drastically reduce reagent consumption and overall assay costs. This is particularly crucial for expensive enzymes and probes, providing a tangible return on investment.
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Accuracy and Precision: Our platforms have been validated to achieve high accuracy in genotyping, with published data showing greater than 93% accuracy in calling genetic markers. The precise control over fluid flow and reaction conditions within the chip ensures highly reproducible results.
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Speed and Scalability: The ability to generate droplets at kilohertz rates allows for rapid data acquisition, significantly reducing turnaround times. Furthermore, the design of our chips makes them scalable for high-volume applications without requiring a larger physical footprint.
FAQs
Q: How does microfluidic technology enable cost reduction in experiments?
A: The primary mechanism for cost reduction is the miniaturization of reaction volumes. Microfluidic channels allow for precise control of fluids at the microliter, nanoliter, or even picoliter scale, which significantly decreases the amount of expensive reagents, enzymes, and probes required for each assay. This high level of miniaturization makes large-scale screening and analysis economically viable for a wider range of projects.
Q: What is the process for adapting existing biochemical protocols for use on a microfluidic chip?
A: Adapting a protocol involves a careful process of micro-engineering and assay optimization. We analyze the critical steps of your existing protocol, such as mixing, incubation, and thermal cycling, and then design on-chip components to replicate these functions at a miniature scale. This often requires adjusting reaction kinetics, fluidic flow rates, and thermal management to ensure the assay's performance and integrity are maintained or enhanced within the microfluidic environment.
Q: What technical factors contribute to the accuracy and reliability of results from a microfluidic platform?
A: High accuracy and reliability are achieved through precise control over multiple factors. The laminar flow characteristics within microfluidic channels eliminate turbulence and ensure uniform mixing. The controlled microenvironment allows for precise thermal regulation, which is critical for temperature-sensitive reactions like PCR. Furthermore, the automation of liquid handling minimizes human error and sample cross-contamination, while integrated optical detection systems provide highly sensitive and reproducible data collection.
Q: For what types of projects is a custom microfluidic chip most suitable?
A: A custom microfluidic chip is most suitable for projects requiring a high degree of specificity, throughput, or automation. This includes large-scale genotyping studies, combinatorial screening, or developing new point-of-care diagnostic devices. The technology excels where sample volumes are limited, reagent costs are a concern, or where traditional methods are too slow or labor-intensive to meet the project's requirements.
Creative Biolabs is a leader in microfluidic technology, providing innovative and reliable solutions for genetic analysis. Our custom Microfluidic Chip Development Service for Microsatellite DNA Detection is engineered to overcome the limitations of traditional methods, offering unparalleled speed, accuracy, and cost-efficiency. By partnering with us, you gain access to a platform that can transform your research and accelerate your path to discovery.
Featured Services
Feature Products
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CAT No
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Material
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Product Name
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Application
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MFCH-001
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Glass
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Herringbone Microfluidic Chip
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Processing samples and reagents in Nucleic acid analysis, blood Analysis, immunoassays and point-of-care diagnostics.
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MFMM-0723-JS12
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Glass
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Double Emulsion Droplet Chip
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Our double emulsion microfluidic chip, incorporating localized modifications and a classic flow-focusing structure, is specifically designed to generate stable and uniform double emulsion droplets.
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MFCH-005
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PDMS
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3D Cell Culture Chip-Neuron
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Neuron cell culture and study of axon transport, axon protein synthesis, axon damage/regeneration, signal transduction of axon to somatic signal.
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MFCH-009
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PDMS
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Synvivo-Idealized Co-Culture Network Chips (IMN2 radial)
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SynBBB 3D Blood Brain Barrier Model/SynRAM 3D Inflammation Model/SynTumor 3D Cancer Model/SynTox 3D Toxicology Model
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MFMM1-GJS4
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COC
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BE-Doubleflow Standard
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Studying circulating particles, cell interactions and simple organ on chip system construction.
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MFMM1-GJS6
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COC
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BE-Transflow Custom
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Used to construct cell interface or Air-Liquid interface (ALI) to study more complex culture systems.
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Click here to Explore our complete product catalog.
Consult our specialists for detailed insights and project-specific deliberations.
Reference
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Yuan, Huiling et al. "Microfluidic screening and genomic mutation identification for enhancing cellulase production in Pichia pastoris." Biotechnology for biofuels and bioproducts vol. 15,1 50. 14 May. 2022, https://doi.org/10.1186/s13068-022-02150-w
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Fergola, Andrea et al. "Droplet Generation and Manipulation in Microfluidics: A Comprehensive Overview of Passive and Active Strategies." Biosensors vol. 15,6 345. 29 May. 2025, https://doi.org/10.3390/bios15060345
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Distributed under Open Access license CC BY 4.0, without modification.
