Background What We Can Offer? Workflow Why Choose Us? Published Data FAQs Featured Services Feature Products
Accelerate Your Research and Development!
Are you currently facing challenges such as a lack of spatiotemporal control over the cellular microenvironment, high reagent consumption, or the inability to perform real-time, single-cell analysis? Our custom microfluidic chip development service helps you overcome these hurdles by providing an integrated, one-stop solution for precise control and analysis, enabling you to gain deeper insights into cellular behavior.
Contact our team to get an inquiry now!
Background
Microfluidics is a powerful technology that provides precise control of fluid flow on a micro-scale. This approach has revolutionized cellular and biochemical analysis by creating miniaturized environments that mimic in vivo conditions and allow for high-precision study of cell behavior. Managing small fluid volumes offers advantages like reduced reagent consumption, faster reaction times, and enhanced sensitivity. These "Labs-on-a-Chip" integrate functions like mixing, separation, and detection into a single device, enabling detailed analysis of cellular responses to stimuli and metabolic activity.
Chips for cell analysis fall into several categories:
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Droplet-Based Microfluidics: Encapsulates cells or reagents in discrete droplets for high-throughput screening and single-cell analysis.
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Continuous-Flow Systems: Uses constant flow to create chemical gradients, sort cells, or simulate blood flow.
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Organ-on-a-Chip Platforms: Mimics the architecture and function of human organs for disease modeling and drug toxicity screening.
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Integrated Sensing Microfluidics: Incorporates on-board sensors for real-time, non-invasive measurement of cellular activity.
Fig.1 Biochemical analysis on microfluidic chips.1
Applications
Our Microfluidic Chip Development Service finds a wide range of applications across the life sciences and biopharmaceutical industries due to its ability to provide precise control and miniaturization.
Drug Discovery and Screening
High-throughput screening of drug candidates by culturing cells and analyzing their responses to different compounds in a miniaturized, parallelized format.
Single-Cell Analysis
Isolation and analysis of individual cells to study cellular heterogeneity, gene expression, and protein secretion at a single-cell level.
"Organ-on-a-Chip" Systems
Development of complex microfluidic devices that mimic the functions of human organs, providing more physiologically relevant models for disease modeling and drug toxicity testing.
Cellular Metabolism and Signaling Pathway Analysis
Real-time monitoring of metabolic changes and signaling events in cells by controlling the delivery of nutrients and waste removal.
Point-of-Care Diagnostics
Creation of portable, low-cost diagnostic devices for rapid detection of biomarkers in small sample volumes, enabling faster disease diagnosis and personalized medicine.
What We Can Offer
Creative Biolabs is your comprehensive partner for all microfluidic needs. We offer a range of products and services designed to help you achieve your research goals.
We provide rapid and high-quality fabrication of custom microfluidic chips from a variety of materials.
Our expert team works with you to design a chip from scratch, tailored to your specific research requirements.
A selection of pre-designed microfluidic chips for standard applications like cell culture, droplet generation, and cell sorting.
From initial consultation and design to fabrication, validation, and final delivery, we provide an end-to-end service to streamline your project.
Leverage our specialized benefits—Request a quotation today
Workflow
Why Choose Us?
Creative Biolabs offers a distinct advantage in the field of microfluidics, combining deep scientific expertise with a commitment to rapid, high-quality project execution. Our platform is distinguished by unparalleled precision, cost-effectiveness, and a proven track record of helping clients achieve their research goals faster.
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Customized Design: We don't offer one-size-fits-all solutions. Our team works with you to design a chip that is perfectly tailored to your unique experimental needs.
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Enhanced Precision: Our microfluidic chips provide superior control over the cellular environment, enabling you to conduct experiments with high spatiotemporal resolution that is not possible with traditional bulk methods.
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Cost-Effectiveness: By minimizing sample and reagent consumption, our microfluidic solutions significantly reduce operational costs, making complex, high-throughput experiments more accessible.
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Rapid Prototyping: Our streamlined design-to-fabrication workflow ensures a fast turnaround time, allowing for quick design iterations and accelerating your project timeline.
Published Data
Fig.2 Analysis of blood sample using FISH based on microfluidic chip.2,
A review of the integrated "Fish-on-a-chip" system highlights its benefits for the early and cost-effective diagnosis of Alzheimer's disease (AD). This modern approach offers advantages over traditional Fluorescence In Situ Hybridization (FISH), including faster detection and reduced sample and reagent use. The method utilizes fluorescently labeled peptide nucleic acid (PNA) probes to detect genetic indicators like single nucleotide polymorphisms (SNPs). Published studies confirm that this microfluidic system provides a highly sensitive and efficient diagnostic tool for detecting AD-related biomarkers and genetic sequences compared to conventional methods.
FAQs
Q: How do microfluidic chips enable researchers to more accurately model in vivo conditions?
A: Microfluidic chips offer the unique ability to recreate the dynamic physiological environment found in the human body. Unlike static culture systems, they allow for continuous perfusion of culture media, which simulates blood flow and nutrient/waste exchange. The small scale also enables the precise control of chemical and mechanical gradients, such as oxygen, pH, or fluid shear stress, which are crucial factors in cell behavior in vivo. This level of control allows for the development of sophisticated "Organ-on-a-Chip" models that more closely mimic organ-level functions and disease states.
Q: How can microfluidic systems be used for real-time monitoring of cellular processes?
A: Many microfluidic chips are designed with integrated sensors and are compatible with advanced imaging techniques. This allows researchers to perform real-time, non-invasive monitoring of cellular processes. For example, on-chip electrochemical sensors can measure changes in pH or oxygen consumption, while microscopy can capture dynamic events like cell migration, division, and apoptosis. This real-time data provides a temporal dimension to experiments, offering deeper insights into biological mechanisms and drug responses than traditional endpoint assays.
Q: What are the primary advantages of microfluidic systems in terms of sample and reagent efficiency?
A: The miniature dimensions of microfluidic chips mean they operate with extremely small volumes, typically in the nanoliter to picoliter range. This drastically reduces the consumption of precious and costly reagents, such as antibodies, proteins, or rare cell samples. This efficiency is particularly beneficial for high-throughput screening campaigns, where a large number of conditions need to be tested, leading to significant cost savings and enabling experiments that would be prohibitively expensive with conventional methods.
Q: How can microfluidic platforms be adapted for single-cell analysis?
A: Microfluidic technology provides unparalleled control over individual cells, making it ideal for single-cell analysis. Channels can be designed to trap, isolate, and manipulate single cells in a controlled environment. Droplet microfluidics, for instance, can encapsulate individual cells within discrete droplets, allowing for high-throughput screening and analysis of a large number of single cells. This level of control enables the study of cellular heterogeneity and provides insights into unique cell behaviors that would be masked in population-based studies.
Q: What are the challenges in scaling up a microfluidic assay from a proof-of-concept to a high-throughput format?
A: Scaling up a microfluidic assay involves several considerations. The transition from a simple prototype to a high-throughput platform requires careful optimization of the fluidic control system to ensure consistent and parallel operation across multiple channels. Maintaining uniformity in flow rates, temperature, and reagent delivery across a large array of micro-chambers is critical for data reproducibility. Additionally, the integration with automated handling systems and data processing pipelines must be robust to manage the large volume of data generated, ensuring the reliability and efficiency of the entire process.
Featured Services
Feature Products
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CAT No
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Material
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Product Name
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Application
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MFCH-001
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Glass
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Herringbone Microfluidic Chip
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Processing samples and reagents in nucleic acid analysis, blood analysis, immunoassays and point-of-care diagnostics.
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MFMM-0723-JS12
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Glass
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Double Emulsion Droplet Chip
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Our double emulsion microfluidic chip, incorporating localized modifications and a classic flow-focusing structure, is specifically designed to generate stable and uniform double emulsion droplets.
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MFCH-005
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PDMS
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3D Cell Culture Chip-Neuron
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Neuron cell culture and study of axon transport, axon protein synthesis, axon damage/regeneration, signal transduction of axon to somatic signal.
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MFCH-009
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PDMS
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Synvivo-Idealized Co-Culture Network Chips (IMN2 radial)
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SynBBB 3D Blood Brain Barrier Model/SynRAM 3D Inflammation Model/SynTumor 3D Cancer Model/SynTox 3D Toxicology Model
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MFMM1-GJS4
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COC
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BE-Doubleflow Standard
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Studying circulating particles, cell interactions and simple organ on chip system construction.
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MFMM1-GJS6
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COC
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BE-Transflow Custom
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Used to construct cell interface or Air-Liquid interface (ALI) to study more complex culture systems.
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Click here to explore our complete product catalog.
For detailed inquiries regarding our offerings, reach out to our specialists.
References
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Lee, Chang-Soo. "Grand challenges in microfluidics: a call for biological and engineering action." Frontiers in Sensors 1 (2020): 583035. Distributed under Open Access license CC BY 4.0, without modification. https://doi.org/10.3389/fsens.2020.583035
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Devadhasan, Jasmine P et al. "Fish-on-a-chip: a sensitive detection microfluidic system for Alzheimer's disease." Journal of biomedical science vol. 18,1 33. 28 May. 2011, Distributed under Open Access license CC BY 2.0, without modification. https://doi.org/10.1186/1423-0127-18-33
