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Creative Biolabs is one of the well-recognized experts who are professional in applying advanced microfluidic chip technologies for a broad range of project objectives. Depending on novel research methods and tools, we are capable of meeting the specific need of each customer with the best project design. Now we focus on microfluidic chip development for cell counting.

Microfluidic Chips for Bacterial Cells Counting

The determination of bacterial numbers in freshwater is a basis for microbiological water quality evaluation, and fluorescence microscopy has been widely used for the detection of bacterial in aquatic environments. However, these traditional methods are often labor-consuming or complex. Scientists have developed a newly designed microfluidic device for bacterial cell counting. Without sample preparation, the system can determine bacterial cells at a density of 10⁴ to 10⁶/ml.

Fig.1 Operation of the fabricated device uses signals from light scattering to count cells. (Machado, 2013)

Microfluidic Chips for Phytoplankton Cells Counting

Phytoplankton species are key components of marine ecosystems and play an important role in biogeochemical cycles. As phytoplankton cells are affected very rapidly by environmental disturbances and may cause harmful cascading effects on biological communities, automatic phytoplankton monitoring techniques are required. Scientists have developed a PDMS-based microfluidic device for phytoplankton cells counting in culture solution. The results showed that compared with a manual microscopic counting method, the automatic counting experiments present reliable data.

Fig.2 Detail of the microfluidic device for on-chip staining and counting. (Yamaguchi, 2011)

Microfluidic Chips for Full Blood Counting

Full blood count (FBC) is a classical diagnostic test to measure the cellular composition of blood. As a diagnostic tool or monitoring solution, it may provide information about the immune system status of the patients. In addition, the FBC has been served as a monitoring tool for the care cycles of various diseases, such as oncology, arthritis, and Crohn's disease. Currently, there are a series of devices have been developed for the measurement of individual components of the FBC. However, they cannot provide all parameters that are required for an FBC at once. Scientists have developeda novel microfluidic device for FBC which can measure all parameters from a finger-prick of blood, such as a white blood cell (WBC) differential count, a red blood cell (RBC) count, a platelet count, and a hemoglobin (Hb) measurement.

Advantages of Microfluidic-Based Cells Counting

• Good portability in different environments
• Reliable results compared with a manual microscopic counting method
• Faster analyses
• Less sample and reagents are required
• Reduced biohazard risk

With years of experience, our scientists have developed various microfluidic chips with the highest quality standards for different purposes. We can also offer custom solutions in case our standard chips do not meet your requirements. If you are interested in our services, please do not hesitate to contact us for more detailed information.

References

1. Machado, L.; et al. Microfluidic biochip for phytoplankton cell counting. 28th Symposium on Microelectronics Technology and Devices (SBMicro 2013). 2013: 1-4.
2. Yamaguchi, N.; et al. Rapid, semiautomated quantification of bacterial cells in freshwater by using a microfluidic device for on-chip staining and counting. Applied and Environmental Microbiology. 2011, 77(4): 1536-1539.

For Research Use Only. Not For Clinical Use.