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Creative Biolabs is a leading global CRO company that focuses on microfluidic chip development. With our extensive experience and advanced platform, we have won a good reputation among our worldwide customers for accomplishing many challenges in the field of microfluidic-based polymer microparticle synthesis. We guarantee the finest results for our customers all over the world.

Introduction to Polymer Microparticle

Polymer microparticles are a group of biomaterials with sizes from 1 to 1000 µm. Polymer microparticles have been treated as a drug delivery strategy and are broadly used in many therapeutic applications. Polymer microparticles do not need to be removed from the body, with high stability and high reproducibility, making them a powerful tool for the development of hydrophilic and hydrophobic drugs. Moreover, recent reports have revealed that polymer microparticles can regulate long-time drug release rates and reduce drug toxicity. Before determining suitable methods for the synthesis of polymer microparticles, an understanding of the drug properties, such as solubility, biocompatibility, as well as crystallinity, is necessary.

Fig.1 Scheme of the morphology of polymeric microparticles prepared by the single- and double-emulsion method. (Vilos, 2012)

In general, the conventional microemulsion method provides a unique opportunity to prepare polymer microparticles with suitable size and perfect internal structure. Among them, the single emulsion is a type of the oil/water (o/w) or water/oil (W/O) emulsion method for the production of solid particles, which usually have a polymer core, in favor of coating hydrophobic drugs. In addition, hydrophilic drugs, like proteins, are usually encapsulated in water/oil/water (w/o/w) double emulsions because they produce core-shell microparticles with hydrophilic encapsulation characteristics. However, numerous data have indicated that this method can lead to an increase in particle size and a decrease in drug loading rate. As a consequence, there is an urgent need to develop other attractive strategies to engineer, synthesize, and produce new polymer microparticles in different clinical practices.

Microfluidic Solutions for Polymer Microparticle

In recent years, microfluidic technology has been regarded as a key way of synthesizing polymer microparticles. This technique can produce droplets or particles in a device that is supplied with a polymer and a drug containing an immiscible solution. In this condition, droplets can be solidified through polymerization or solvent evaporation. Microfluidics allows the generation of a large number of polymer microparticles with predictable size and better stability, which provides support data in the synthesis of various polymer microparticles loaded with candidate drugs of biomedical interest. For example, it has been described that the activity of polymeric microparticles loaded with small molecule drugs has been evaluated in C6 glial cells of a mice tumor model. The data have suggested that an appropriate route of drug administration loaded in polymeric microparticles can achieve continuous release of the drug and decrease its potential side effect on patients.

Fig.2 Optical image of an ultramicrotomy cut of a ZnO/ZnO core-shell microparticle. (Serra, 2013)

Our Polymer Microparticle Platform

By continuing to grow in response to the requirements of our clients, Creative Biolabs is dedicated to exploring novel and innovative microfluidic technologies to offer the most comprehensive, integrated portfolio of polymer microparticle products and solutions. We offer a wide collection of microfluidic-based services for our clients to design, engineer and synthesize novel polymer microparticle proteins. Our microfluidic platform is suitable for a variety of polymer microparticle development, as well as several potential drug deliveries. Besides, we also provide a diverse range of microfluidics-based analysis services to analyze the safety and effectiveness of your polymer microparticles. In our labs, the physicochemical properties, such as particle size, particle shape, particle inner structure, particle porosity, load capacity, encapsulation efficiency, and release rate, will be fully assessed for reaching expected pharmacological effects.

Service Highlight

• A well-mature microfluidic-based particles synthesis platform
• Suitable for various types of particles
• High stability and high throughput screening
• High biodegradability and biocompatibility
• Controlled drug delivery identification

Creative Biolabs is a leader in the field of microfluidic chip development and particle synthesis for years. With in-depth expertise in molecular modeling, structural analysis, particle studies, as well as safety evaluation, we offer a high throughput microfluidic-based polymer microparticle synthesis service basing on a full range of state-of-the-art technologies. If you are interested in our services, please contact us for more details. Let us know what you need and we will accommodate you. We look forward to working with you in the future.

References

1. Vilos, C., et al. Therapeutic strategies based on polymeric microparticles. Journal of Biomedicine and Biotechnology. 2012.
2. Serra, C. A., et al. Engineering polymer microparticles by droplet microfluidics. Journal of Flow Chemistry. 2013, 3(3): 66-75.

For Research Use Only. Not For Clinical Use.