Microfluidics-Based Analysis in Precision Medicine

Inquiry

Creative Biolabs is confident in providing our clients with comprehensive and multi-functional microfluidic precision medical solutions. Microfluidic science has greatly broadened the possibilities of medical and biological research, providing usable tools for personalized and precision medicine for specific patients.

Precision Medicine

With the expansion of biological detection methods and coverage, medicine is developing in a more predictive, preventive, personalized and participatory direction. Traditional medicine is often based on broad demographic or symptomatic statistics to formulate treatment strategies, especially a one-size-fits-all intervention for cancer. Personalized medicine uses health data and pathological test results to create plans that vary from person to person, minimize the harm caused by drugs that have no effect on patients, build more effective targeted medical care, and reduce the cost of drugs greatly. Microfluidic assays are often automated, scalable, and highly integrated working devices that offer viable solutions for point-of-care and nanoliter-scale bioanalysis.

Fig 1. Microfluidic molecular diagnostic for precision medicine. (Ayuso, et al., 2022)

Microfluidic-Based Precision Medicine in Cancer

Traditional dish-based assays completely ignore the complexity and heterogeneity of tumors, and chemotherapy drugs that target basic cell functions are administered immediately after a patient is diagnosed with cancer. Precision oncology involves screening patients at the molecular level, predicting drug response, and assessing the recovery of cells and tissues in the follow-up process. Microfluidic systems have good operability and integrated detection capabilities for circulating tumor cells (CTC), which are most likely to provide genetic information for heterogeneous tumors. Novel microfluidic devices achieve high sensitivity and specific capture of CTC cells in whole blood cells, replace traditional methods with liquid biopsy, and maximize the use of the rarity and phenotypic heterogeneity of CTCs. The integrated microfluidic system can provide more functions and information in addition to CTC isolation, including counting, phenotypic characterization, and molecular profiling. Small-volume, high-throughput microfluidic devices can also be used for rapid, high-throughput analysis of other analytes in human samples, including proteins, exosomes, signaling molecules, or circulating tumor DNA.

Organ-on-Chips for Precision Medicine

By simulating physiological functions at the organ level in a controlled microenvironment, organ-on-a-chip personalizes individual physiological/pathological conditions. By implanting human tissues, blood samples, and primary cells into well-characterized microfluidic systems, and designing aspects of the physical, chemical, and biological microenvironments based on user health data, personal data and physiologically relevant metrics can be captured, to conduct a comprehensive private assessment of drug efficacy and safety, formulate the best-personalized strategies for disease intervention. With increased control and automation, reverse engineering of how health parameters affect an individual's health becomes possible. The dynamic nature of the microfluidic system also makes health data and evaluation results controllable and real-time changes over time, which is very important for data evaluation of personalized medicine.

Fig 2. Organ-on-chip for personal health data collection. (Albert, et al., 2018)

Creative Biolabs is committed to providing our clients with the most comprehensive and reliable one-stop precision medical microfluidic system solutions. You may have direct access to our mature and well-characterized organ-on-a-chip products for downstream testing. We are also willing to develop and build suitable microfluidic system for you to meet your functional presets and experimental needs. Our highly flexible and precise medical microfluidic system will be the best alternative tool for you to plan drug regimens and obtain personalized health information, and will greatly help you successfully implement precision medicine regimens for various diseases. Please don't hesitate to contact us to discuss your need and for more information.

References

Ayuso, J.M; et al. A role for microfluidic systems in precision medicine. Nature Communications. 2022, 13, 2086.
Albert, B; et al. Personalised organs-on-chips: functional testing for precision medicine. Lab on a Chip. 2018, 19, 198-205.

For Research Use Only. Not For Clinical Use.