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Wearable sensors offer the possibility of real-time, non-invasive analysis of physiological status or motion monitoring. Recent advances in our microfabrication technology allow Creative Biolabs to develop and construct miniaturized and integrated microfluidic wearable sensors for clients around the world, through which you may create advanced sensing strategies that interface with the human epidermis as well as explore new avenues for in situ real-time physiological detection.

Microfluidic Wearable Sensor

Non-invasive, real-time, non-stimulant continuous monitoring is the ultimate goal of a novel generation of motion sensors and health care detection. In past research, wearable sensing devices have been gradually combined with various technologies, including flexible electronics, electrochemical sensing, painless microneedles, near-field communication and even mega data cloud computing. Recent advances in biocompatible materials are driving the integration of microfluidic approaches with wearable sensors. Although still in its infancy, wearable sensing devices have a strong foundation thanks to many advanced technologies.

Fig.1 Flexible biocompatible material processing technology is the basis for fabricating microfluidic wearable sensors. (Fallahi, et al., 2019)

Biological Fluids

As an alternative to traditional macroscopic experimental techniques, novel wearable biosensors are light, portable, and flexible. Due to the difficulty of obtaining and the abundance of physiological information contained, the biological fluids usually used for information collection mainly include:

• Blood­­ is the most classic and primitive biological information fluid, but its acquisition needs to puncture the skin, which is often not suitable for wearable sensors. Recent research has realized the in situ detection of physiological information without blood collection through photoelectric biosensing elements, but its practical application still needs further development.
• Saliva­­ is considered to be one of the blood substitutes. Non-invasive analysis of metabolites was achieved by loading electrochemical sensors onto the mouthguard.
• Urine­­ can be collected non-invasively in large quantities and has been widely used for general health monitoring and disease screening. But urine collection is directly related to personal hydration levels, making wearable sensing rather difficult.
• Tears­­ provide more complex physiological information than blood, but using contact lenses as in situ biosensors requires sophisticated proximal wireless power transfer devices.
• Interstitial fluid undergoes frequent fluid exchange with blood through capillaries, resulting in similar concentrations of many analytes to blood. Microneedle patches without blood sampling have been well-designed and used for minimally invasive interstitial fluid sensing.
• ­­Sweat is the most readily available and widely used biofluid for wearable microfluidic sensors. Sweat contains a wealth of victory-related information, including hydration, drug metabolism, kidney function, electrolyte balance, and exercise intensity, to name a few.

Fig.2 In situ sweat sensor by optical colorimetric comparison. (Baker, et al., 2020)

Biological Analytes

We can conjugate various types of biomarkers to the appropriate substrate surface with amazing stability. The biomarkers commonly collected by wearable microfluidic biosensors are listed below.

Our Services

Creative Biolabs is committed to providing our clients with the best, most reliable and fast microfluidic chip design and construction services. With our help, you may develop and create personalized microfluidic wearable biosensors, taking your experiments to new levels never before possible. As a young and novel discipline, microfluidic wearable sensors explore biofluids to the greatest extent. With this untapped resource, you will achieve real-time, continuous, non-invasive continuous detection for the physiological state, drug metabolism and exercise performance. Don't hesitate to contact us for more information.

References

1. Fallahi, H.; et al. Flexible microfluidics: fundamentals, recent developments, and applications. Micromachines. 2019, 10: 830.
2. Baker, L.; et al. Skin-interfaced microfluidic system with personalized sweating rate and sweat chloride analytics for sports science applications. Science Advance. 2020, 6: 3929.

For Research Use Only. Not For Clinical Use.