Electrochemical Sensor Development Service

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Electrode miniaturization and microfluidic integration have profoundly reshaped the field of electrochemical sensing. Creative Biolabs has optimized the strategy for the demanding field of microfluidic electrochemical sensing, and the integration of microfluidic systems and electrochemical sensing will open up unprecedented opportunities for research in biology, chemistry, and pharmacy.

Why Choose Microfluidic Electrochemical Sensor?

Microfluidic devices are a combination of microchannels and microchambers, which have shown great application potential by combining different materials and functional units. In recent years, the development of innovative nanomaterials and the development of precision processing technology have brought more possibilities to microfluidic devices, especially the integration of reliable electrochemical sensing systems in microdevices.

Fig.1 Microfluidic units manage fluid flow, and electrochemical units are for detection. (Lee, et al., 2017)

Here at Creative Biolabs, the combination of microelectromechanical systems and microfluidic devices has developed unlimited exploration space for both, and has brought a series of advantages that traditional analytical experiments do not have:

The risk of contamination is greatly reduced by closed equipment,
Allow the integration of multi-channel analysis,
Fewer samples/reagents required,
Short analysis time with high efficiency,
High spatial resolution and improved electrical signal-to-noise ratio,
The miniaturized device reduces power consumption and provides portability,
Controlled flow allows reaction time manipulation and even enables experimental reconfiguration,
Flow devices enable efficient and long-term detection of biomarkers,
Allows for parallel monitoring and multi-channel analysis.

Creative Biolabs takes full advantage of the reliability and precision of electrochemical sensing systems and endows them with excellent controllability through modular units of microfluidic systems. Combining multiple advantages, we design and develop different microfluidic electrochemical sensors based on different detection principles for our customers.

Fig.2 Square-wave anodic voltammetry detection by a microfluidic electrochemical sensor. (Shen, et al., 2017)

Microfluidic Electrochemical Detection

Electrochemical detection in microfluidics is often based on the traditional principle of immunoreaction. Changes in the active components in the solution or changes in the charge density on the sensitive interface cause detectable changes in current or potential parameters. The most commonly used three-electrode sensor consists of a working electrode (WE), a counter electrode (CE) and a reference electrode (RE). CE directly connects the electrolyte to apply current to the microchannel, RE measures the potential in the channel without current passing, and WE directly contacts the reacted analyte to derive the working potential. Regular electrochemical parameters can be converted into quantitative or qualitative detection values in downstream analysis.

Fig 3. Construction of biosensor by three-electrode configuration. (Shin, et al., 2017)

Our Services

The iteration of the detection principle and chip function determines the structure and design diversity of microfluidic electrochemical sensors. Extensive knowledge of bio-immunology and cutting-edge microfabrication technology platforms allow Creative Biolabs to transfer traditional electrochemical detection to microfluidic platforms with automated and controlled systems. With our help, you can design and customize integrated electrochemical monitoring platforms that meet any needs which can be applied to many fields such as molecular biology detection, disease diagnosis, ion analysis, and single-cell metabolic tracking with extremely high precision. Please don't hesitate to contact us for any needs.

References

Lee, G.; et al. Single microfluidic electrochemical sensor system for simultaneous multi-pulmonary hypertension biomarker analyses. Nature. 2017, 7: 7545.
Shen, L.L.; et al. Modifier-free microfluidic electrochemical sensor for heavy-metal detection. ACS Omega. 2017, 2: 4593-4603.
Shin, S.R.; et al. Label-free and regenerative electrochemical microfluidic biosensors for continual monitoring of cell secretomes. Advanced Science. 2017, 4: 1600522.

For Research Use Only. Not For Clinical Use.