Protein Encapsulation

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Creative Biolabs has long-lasting expertise in the design and production of microfluidic chips for a broad range of project objectives. Based on our advanced platform and extensive experience, now we can provide the novel microfluidic-based protein encapsulation service for our clients all over the world.

Protein Encapsulation in Drug Discovery

Maintenance of drug concentration in the bloodstream or tissue is the crucial factor for drug formulation and drug dosage determination. In general, there are two methods for drug concentration maintenance, which include multiple drug administration at predefined intervals and a single administration of a long-lasting drug formulation. Compared with the former, the latter is a novel approach that reduces the frequency of drug administration. For protein drugs, protein encapsulation in a micro- or nanocarrier is a common approach to achieve a constant release rate over time. After administration, the protein drug can be released from the polymer matrix.

Schematic diagram of the double emulsion generating microfluidic system used for BSA encapsulation in PLLA microsphere. Fig.1 Schematic diagram of the double emulsion generating microfluidic system used for BSA encapsulation in PLLA microsphere. (Bokharaei 2016)

Microfluidic-Based Protein Encapsulation

In general, poly (lactic acid) and poly (glycolic acid) and their copolymers are the most common polymers used for protein encapsulation. The rate of polymer degradation rate depends on the polymer molecular weight and its hydrophobicity. In addition, the particle size is also important for the drug release rate from the particles. In this case, the particles with narrow size distribution are essential to accomplish a reliable and predictable sustained release drug delivery system. As previously described, microfluidic systems present great advantages for the production of the narrow-sized microsphere. In order to encapsulate proteins inside the microspheres, the double emulsion technique and a water-in-oil-in-water (w/o/w) emulsion generated from a microfluidic system are necessary to maximize the encapsulation efficiency. Creative Biolabs can design the microfluidic system for protein encapsulation in biocompatible polymers.

Schematic microfabrication process of the microfluidic system for double emulsion generation system. Fig.2 Schematic microfabrication process of the microfluidic system for double emulsion generation system. (Bokharaei, 2016)

Advantages of Microfluidic-Based Protein Encapsulation

With years of experience, our scientists have developed various microfluidic chips with the highest quality standards for different purposes. We can also offer custom solutions in case our standard chips do not meet your requirements. If you are interested in our services, please do not hesitate to contact us for more detailed information.

Reference

  1. Bokharaei, M. Design and optimization of a microfluidic system for the production of protein drug loadable and magnetically targetable biodegradable microspheres. University of British Columbia. 2016.

For Research Use Only. Not For Clinical Use.

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