API Encapsulation

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Recent researches have shown the potential benefits brought by microfluidic tools to the formulation, that is, nanoprecipitation, of polymeric nanoparticles loaded with active pharmaceutical ingredients (APIs), lipoplexes, or even pure drug nanoparticles. With years of experience focusing on microfluidic-based encapsulation, Creative Biolabs is capable of providing high-quality microfluidic-based API encapsulation services to global clients.

Introduction of Microfluidic-based API Encapsulation

Microfluidics deals with the movement of small volumes of fluids in capillaries of several hundred or tens of micrometers in diameter. In the last decade, these technologies have advanced significantly largely facilitated by progress in the electronics industry. Recently, the applications of microfluidics have been considerably expanded to the multidisciplinary fields of biotechnology including the wide use of micro/nanoparticles-based drug delivery systems for small drug molecules.

Application of Microfluidic-based API Encapsulation

There are two kinds of outstanding applications, on the one hand, lipid-based systems mainly for encapsulating oligonucleotides forming lipoplexes, and on the other hand, polymer nanocarrier, mainly dedicated to encapsulating the antitumor agent with potential surface modification towards active targeting. These two different applications have already existed in batch systems for many years, but they both found high improvements through their adaptation to the microfluidic technologies in the control of size, size distribution, and in general in the accurate control of the nanocarrier fabrication process.

Polymer nano-precipitation by the flow-focusing method. Fig.1 Polymer nano-precipitation by the flow-focusing method. (Khan, 2015)

Advantages

Services at Creative Biolabs

Creative Biolabs has established a comprehensive microfluidic-based encapsulation platform and equipped it with advanced facilities and excellent scientists. During the years of period focusing on this field, we have successfully accomplished a number of customer-satisfied projects. In this context, we are confident in providing reliable microfluidic-based API encapsulation services to global clients. If you are looking for an appropriate method for API encapsulation, please don’t hesitate to contact us for more information.

Reference

  1. Khan, I. U.; et al. Production of nanoparticle drug delivery systems with microfluidics tools. Expert Opin Drug Deliv. 2015, 12(4): 547-62.

For Research Use Only. Not For Clinical Use.

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