Design and fabrication of bespoke microfluidic chips in various materials (PDMS, glass, silicon, etc.) to meet specific application requirements.
Are you currently facing challenges with high sample consumption, long turnaround times, or limited throughput in your peptide and protein analysis workflows? Creative Biolabs' Microfluidic Development Service helps you overcome these limitations by providing customized lab-on-a-chip solutions, enabling high-sensitivity analysis with minimal sample volumes. Through advanced microfluidic engineering and integrated detection technologies, we streamline your processes to deliver faster, more reliable results.
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Microfluidics, which involves handling fluids at microscopic dimensions, has transformed biochemical research by scaling down conventional lab operations into integrated chip formats. This "lab-on-a-chip" methodology offers a versatile foundation for a wide spectrum of uses, such as examining peptides and proteins. These biologically active compounds, crucial to cell mechanisms, demand precise and high-throughput analytical techniques for applications ranging from biomarker identification to drug manufacturing standards.
Fig.1 HPLC-MS analysis on a microfluidic device.1,3
The controlled environment within microfluidic channels allows for precise sample handling, mixing, and separation, overcoming the limitations of conventional, macro-scale techniques. The benefits of this approach are well-documented in scientific literature, with studies highlighting its ability to enable rapid, high-throughput analysis with minimal sample volumes. For example, microfluidic platforms have been successfully coupled with advanced detection methods like mass spectrometry (MS) and laser-induced fluorescence (LIF) to achieve exceptional sensitivity. Furthermore, the technology's ability to manipulate individual cells and their contents has opened new avenues for single-cell proteomics, revealing cellular heterogeneity that is often masked by traditional bulk analysis.
Our microfluidic solutions are highly versatile and can be applied across numerous fields:
High-throughput screening of drug candidates, protein-protein interaction studies, and pharmacokinetic analysis.
Identification of disease biomarkers, single-cell protein analysis, and development of point-of-care diagnostic devices.
Detection of contaminants or allergens in food, and monitoring of environmental pollutants.
Rapid, automated analysis for ensuring the purity and integrity of therapeutic proteins.
Creative Biolabs provides a comprehensive suite of products and services tailored to your microfluidic needs:
Design and fabrication of bespoke microfluidic chips in various materials (PDMS, glass, silicon, etc.) to meet specific application requirements.
From initial design and chip fabrication to assay development and system integration, we provide an end-to-end service.
Development of platforms for high-resolution electrophoretic and chromatographic separation.
Creation of chips with integrated detection capabilities for sensitive protein quantification and binding studies.
A selection of off-the-shelf microfluidic chips optimized for common applications like droplet generation, mixing, and simple cell sorting. These are ideal for labs looking for a quick and cost-effective entry point into microfluidics.
Leverage our specialized benefits—Request a quotation today
Creative Biolabs combines deep scientific expertise with a client-centric approach to deliver exceptional microfluidic solutions. Our commitment to innovation, quality, and collaboration sets us apart.
Fig.2 Microfluidic diffusional mixing for the analysis of PPIs.2,3
The article explores the use of microfluidic technologies to study and quantify protein-protein interactions (PPIs). The authors highlight the advantages of microfluidics, such as the ability to control mass transport at the micron scale, which allows for the analysis of proteins in solution without the need for traditional surfaces or solid matrices. The review discusses various microfluidic techniques, including those that use diffusional mixing, electrophoresis, and droplet compartmentalization, and explains how these methods can be used to determine key biophysical parameters like diffusion coefficients and binding kinetics. The article emphasizes how these innovative approaches provide a rapid and native-state analysis of PPIs, addressing some of the challenges associated with conventional bulk experimental methods.
This evaluation examines multiple experimental methodologies and their outcomes. One approach, microfluidic diffusional sizing (MDS), is thoroughly described for characterizing protein-protein interactions by measuring alterations in protein hydrodynamic radius (RH) during binding events. Provided data illustrate MDS implementations, including an analysis of clusterin with amyloid-β fibrils that successfully produced binding kinetics. Another emphasized method utilizes microfluidic platforms for single-molecule Förster resonance energy transfer (smFRET) imaging. The article shows results where the dissociation of protein complexes (e.g., NCBD and ACTR) could be observed and quantified within milliseconds, demonstrating the rapid analysis capabilities of these systems. Furthermore, the review touches on methods that use electrophoretic forces to manipulate and characterize interacting proteins, providing a versatile toolkit for biophysical analysis.
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Custom Microfluidic Fabrication Services | Organ-on-Chip Cell Culture Platform | Droplet Generation All-in-one System |
CAT No | Material | Product Name | Application |
MFCH-001 | Glass | Herringbone Microfluidic Chip | Processing samples and reagents in Nucleic acid analysis, blood Analysis, immunoassays, and point-of-care diagnostics. |
MFMM-0723-JS12 | Glass | Double Emulsion Droplet Chip | Our double emulsion microfluidic chip, incorporating localized modifications and a classic flow-focusing structure, is specifically designed to generate stable and uniform double emulsion droplets. |
MFCH-005 | PDMS | 3D Cell Culture Chip-Neuron | Neuron cell culture and study of axon transport, axon protein synthesis, axon damage/regeneration, signal transduction of axon to somatic signal. |
MFCH-009 | PDMS | Synvivo-Idealized Co-Culture Network Chips (IMN2 radial) | SynBBB 3D Blood Brain Barrier Model/SynRAM 3D Inflammation Model/SynTumor 3D Cancer Model/SynTox 3D Toxicology Model. |
MFMM1-GJS4 | COC | BE-Doubleflow Standard | Studying circulating particles, cell interactions, and simple organ-on-a-chip system construction. |
MFMM1-GJS6 | COC | BE-Transflow Custom | Used to construct a cell interface or Air-Liquid interface (ALI) to study more complex culture systems. |
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References
For Research Use Only. Not For Clinical Use.