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Introduction of Micro/Nano Reactor Chip

With the development of microelectromechanical system (MEMS) technology, the micro-units can be manufactured and integrated into a chip to process different functions. Microfluidic systems allow the manipulation and precision control of fluids, which has been served as a valuable tool for multiple applications, including organic and inorganic synthesis, biotechnology research, and chemical industry. The flexible and rich design of the microfluidic reactor allows the reactions in a micromixing channel or inside the common microchannel/chamber at a microscale.

Fig.1 Nucleic acid hybridization on microfluidic chip for rapid miRNA detection. (Shi 2019)

Micro/Nano Reactor Chip for Biomedical Applications

According to the reaction modes, the microreactor can be divided into ordinary reactors and microfluidic mixing. Through uniform and fast mixing of different samples within the delicate mixing channel, multiple biomedical reactions can be achieved in a microfluidic mixing reactor. The typical biomedical applications of microreactors include on-chip real-time polymerase chain reaction (rtPCR), enzyme-linked immunosorbent assay (ELISA), and nucleic acid hybridization. In order to further minimize the microfluidic devices, there are two commonly used detection methods with high sensitivity, namely miniaturized optical and electrochemical signal acquisition methods.

Micro/Nano Reactor Chip for Diagnostic Application

As a cornerstone of health care research and clinics for a broad spectrum of maladies, the rapid and reliable diagnostic assays largely improve treatment and clinical outcomes. In general, the disease markers, such as DNA, RNA, antigens, present in biological samples with low concentrations. In this case, an amplification reaction is essential for the majority of diagnostic assays. Compared with conventional benchtop reactions, the current microfluidic reactor offers many advantages, including specific, sensitive, inexpensive, rapid, integrated, and automated. What’s more, multiple tests or experimental steps can be performed on one integrated, automated platform based on the channel architecture.

Fig.2 Schematic of a microreactor for strand displacement amplification and amplicon gel electrophoresis. (McCalla 2011)

Advantages of Micro/Nano Reactor Chip

• Reduced reagent consumption
• Improved reaction selectivity and operational safety
• High surface-area-to-volume ratios
• Superior to the macroscopic reaction setting
• Improved control over mass and heat transfer
• Easy integration with other functional units

As a leading custom service provider in the field of microfluidic chip development, Creative Biolabs has won a good reputation among our worldwide customers for successfully accomplishing numerous challenging projects including micro/nano reactor chip development for special functions. With years of experience and advanced platforms, we can offer one-stop microfluidic solutions to meet the special needs of our clients. If you are interested in our services, please do not hesitate to contact us for more detailed information.

References

1. McCalla, S.; Tripathi, A. Microfluidic reactors for diagnostics applications. Annual review of biomedical engineering. 2011, 13: 321-343.
2. Shi, H.; et al. Recent progress of microfluidic reactors for biomedical applications. Chemical Engineering Journal. 2019, 361: 635-650.

For Research Use Only. Not For Clinical Use.