Chip Capillary Electrophoresis

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Introduction of Chip Capillary Electrophoresis

Capillary electrophoresis is a popular analytical technique that allows the separation of molecules based on their electrophoretic mobility with the use of an applied voltage in a capillary tube containing polymer/gel mediums. The electrophoretic mobility is dependent on the charge of the molecule, the viscosity, and the atom's radius. Capillary electrophoresis can be coupled online with MS to be applied for analysis of proteins and peptides. In the early 1990s, chip-based capillary electrophoresis was designed and developed based on the principle of capillary electrophoresis. Microchip capillary electrophoresis can be integrated with various miniaturized functional elements to realizing mixture, reaction, concentration, and separation of analytes on a chip, greatly decreasing injection volumes, reducing separation lengths, resulting in a reduction of analysis time. As a new and powerful analytical technology, microchip capillary electrophoresis is also applied for high-speed separation of biological compounds such as DNA and proteins.

Set-up for the microchip capillary electrophoresis LIF detection system. Fig.1 Set-up for the microchip capillary electrophoresis LIF detection system. (Kuswandi, 2007)

Compared to traditional capillary electrophoresis, chip-based capillary electrophoresis has several advantages, including

Materials of Capillary Electrophoresis Microchips

Microchips Operation

Injection, separation, and detection is a standard analysis protocol for microchip capillary electrophoresis.

Chip Capillary Electrophoresis

Application of Capillary Electrophoresis Microchips

Services at Creative Biolabs

Creative Biolabs is an excellent and world-leading service provider who is devoted to helping our clients to design and develop top-quality microfluidic chips. Equipped with state-of-the-art development facilities and comprehensive expertise, we support a widely full range of microfluidic chip development services. We have accumulated extensive experience in several important projects of microfluidic-based development. Please contact us to let us help you design and develop the best effective microfluidic chip technologies.

Reference

  1. Kuswandi, B.; et al. Optical sensing systems for microfluidic devices: A review. Analytica Chimica Acta. 2007, 601(2):141-155.

For Research Use Only. Not For Clinical Use.

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