Microfluidics-Based Analysis in Cancer Detection

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Creative Biolabs is one of the leading service providers who are professional in microfluidic chip development for a broad range of project objectives. With years of experience, we can offer high-quality one-stop microfluidic solutions to meet our clients’ demands precisely. Particularly, our services involve microfluidics integrated solutions for cancer detection.

Background

Cancer is a class of diseases characterized by the uncontrolled growth of cells that ultimately invade surrounding tissues and metastasize to distant sites within the body. Accurate prediction and diagnosis at an early stage are the most critical issues in cancers. In the past years, significant efforts have been put into finding informative cancer biomarkers for cancer diagnosis, including but not limited to mutated DNAs and RNAs, secreted proteins, and tumor cells (e.g., circulating tumor cells, tumor stem cells). Ideally, the identifications of cancer biomarkers are supposed to be done at high accuracy with automation and cheaply at point-of-care to reduce costs. Unfortunately, the methods performed typically in traditional bench-top laboratories are usually not amenable to high-throughput screening. Recently, microfluidic technologies, also referred to as Lab-on-a-Chip (LOC) or micro-total analysis systems (μTAS), offer tremendous hope in both point-of-care cancer biomarker measurements and personalized diagnostic strategies.

Fig.1 Experimental schemes and microfluidic devices for monitoring multicellular interaction between a single cancer cell and many fibroblasts in the neighbor. (Karakas, 2017)

Microfluidics-based Analysis in Cancer Detection

Microfluidic technologies enable the actuation of fluids and manipulation of bioparticles (e.g. DNA, RNA, proteins, and cells) at the microscale. To date, numerous microfluidics-based analysis methods have been developed for cancer diagnosis in the early stage. At the molecular level, the analysis methods of gene biomarkers including gene mutations, cancer-related methylation, and other alterations were firstly introduced which included microfluidic chip-based capillary array electrophoresis (CAE) and PCR. At the protein level, the identifications of protein biomarkers were conducted by focusing on the interface of microfluidics with IHC, ELISA, and MS. At the cellular level, different microfluidic based methods were extensively employed which include cell sorting, cell culture, and unique manipulation on isolated single cancer cells.

Microfluidics Integrated Solutions at Creative Biolabs

Compared with the traditional macroscale methods, microfluidic devices have slowly emerged as new platforms in a wide range of researches in clinical oncology. Creative Biolabs can help global customers establish microfluidics-based analysis methods for cancer biomarker detection, including but not limited to DNA, RNA, and protein. In addition, our scientists also provide comprehensive microfluidic chip development services for multiple applications.

Highlights

Fast, complete and cost-effective microfluidic-based analysis method development service
Advanced speed and precision while ensuring high-quality outcomes
Abundant experience and professional after-sale service

As one of the most famous industry leaders who are skilled in advanced microfluidic technology, Creative Biolabs not only concentrates on developing cutting-edge technology but also are willing to share our sufficient expertise with our clients to promote their projects. We guarantee to provide customers with the best services and the finest results in the most cost-effective way. If you are interested in our service, please feel free to contact us for more details or directly send us a quote.

Reference

Karakas, et al. A microfluidic chip for screening individual cancer cells via eavesdropping on autophagy-inducing crosstalk in the stroma niche. Scientific reports. 2017, 7(1), pp.1-11.

For Research Use Only. Not For Clinical Use.