Microfluidic devices can be used for chemical reactions and analyses in microchannels and microstructures, which are fabricated by semiconductor microfabrication technology such as photolithography and soft lithography. This technology called Microfluidics or Lab-on-a-chip has been established as an interdisciplinary field of research by combining micro/nano-device technologies, chemical sensor technology, and analytical chemistry in the 1990s.
Among the many functions of microfluidic chips, the detection and sensing functions of microfluidic chips are widely used in many fields. Common microfluidic sensor chips include flow rate measurement chip, chemiluminescence measurement chip, fluorescence detection chip, chip calorimetry, absorbance measurement chip, cell classification/ counting chip, and so on. The microfluidic sensor chip realizes accurate measurement of many parameters, such as refractive index of the sample, local temperature, cell type and size, biochemicals, flow rate, and so on. Besides, the consumption of samples measured in microfluidic chips will be greatly reduced, especially for some precious biochemical samples, which are usually expensive and small in volume.
Fig.1 Schematic diagram of the structure and optical propagation of fiber Bragg grating (FBG) and tilted fiber Bragg grating (TFBG). (Zhao, 2020)
Microfluidic devices are miniaturized fluid handling systems, regulating a small number of fluids traveling through networks consisting of tiny channels with diameters typically ranging from tens to hundreds of micrometers. To perform their tasks, in microfluidic devices, the fluidic flows including reagents or samples must be directed, mixed, separated, or manipulated in controlled manners. The majority of these applications rely on the functional microchannels the fluids transport through, more concretely, the surface effects of microchannels. Therefore, various functional microchannels with specific interactions with the transport fluids are developed to regulate the microscale flow behaviors.
Poly (dimethylsiloxane) (PDMS) microchip based on an immunoagglutination reaction developed to determine albumin concentrations by using small amounts of antibody reagents. Using the PDMS microchip based on an immunoagglutination reaction, a reagent consumption of less than one-tenth that of the conventional immunoassays was achieved.
The biological field-effect transistor (BioFET)-based microchip is a metal-oxide-semiconductor field-effect transistor-type protein sensor with gold deposited on the gate insulator. This BioFET may detect various biomarkers and could be used as part of a LOC due to its compactness and simplicity.
More and more widespread use of microfluidic in medicine has become a trend. As a global-leading CRO company keeping pursuing the frontier of industry, Creative Biolabs has been focusing on microfluidics over years and established a comprehensive one-stop microfluidic solution platform. We are now capable of providing a variety of microfluidic-based services including but not limited to:
If you are interested in microfluidic services or you have any other questions, please don’t hesitate to contact us for more information.
For Research Use Only. Not For Clinical Use.